The Role of MicroRNAs in Dilated Cardiomyopathy: New Insights for an Old Entity
Dilated cardiomyopathy (DCM) is a clinical diagnosis characterized by left ventricular or biventricular dilation and systolic dysfunction. In most cases, DCM is progressive, leading to heart failure (HF) and death. This cardiomyopathy has been considered a common and final phenotype of several entit...
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/21/13573 |
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| author | Elena Alonso-Villa Fernando Bonet Francisco Hernandez-Torres Óscar Campuzano Georgia Sarquella-Brugada Maribel Quezada-Feijoo Mónica Ramos Alipio Mangas Rocío Toro |
| author_facet | Elena Alonso-Villa Fernando Bonet Francisco Hernandez-Torres Óscar Campuzano Georgia Sarquella-Brugada Maribel Quezada-Feijoo Mónica Ramos Alipio Mangas Rocío Toro |
| author_sort | Elena Alonso-Villa |
| collection | DOAJ |
| description | Dilated cardiomyopathy (DCM) is a clinical diagnosis characterized by left ventricular or biventricular dilation and systolic dysfunction. In most cases, DCM is progressive, leading to heart failure (HF) and death. This cardiomyopathy has been considered a common and final phenotype of several entities. DCM occurs when cellular pathways fail to maintain the pumping function. The etiology of this disease encompasses several factors, such as ischemia, infection, autoimmunity, drugs or genetic susceptibility. Although the prognosis has improved in the last few years due to red flag clinical follow-up, early familial diagnosis and ongoing optimization of treatment, due to its heterogeneity, there are no targeted therapies available for DCM based on each etiology. Therefore, a better understanding of the mechanisms underlying the pathophysiology of DCM will provide novel therapeutic strategies against this cardiac disease and their different triggers. MicroRNAs (miRNAs) are a group of small noncoding RNAs that play key roles in post-transcriptional gene silencing by targeting mRNAs for translational repression or, to a lesser extent, degradation. A growing number of studies have demonstrated critical functions of miRNAs in cardiovascular diseases (CVDs), including DCM, by regulating mechanisms that contribute to the progression of the disease. Herein, we summarize the role of miRNAs in inflammation, endoplasmic reticulum (ER) stress, oxidative stress, mitochondrial dysfunction, autophagy, cardiomyocyte apoptosis and fibrosis, exclusively in the context of DCM. |
| first_indexed | 2024-03-09T18:59:45Z |
| format | Article |
| id | doaj.art-90ca7389ad324eb79ebe6b4d61bdd68d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:59:45Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-90ca7389ad324eb79ebe6b4d61bdd68d2023-11-24T05:10:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123211357310.3390/ijms232113573The Role of MicroRNAs in Dilated Cardiomyopathy: New Insights for an Old EntityElena Alonso-Villa0Fernando Bonet1Francisco Hernandez-Torres2Óscar Campuzano3Georgia Sarquella-Brugada4Maribel Quezada-Feijoo5Mónica Ramos6Alipio Mangas7Rocío Toro8Research Unit, Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta del Mar University Hospital, 11009 Cádiz, SpainResearch Unit, Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta del Mar University Hospital, 11009 Cádiz, SpainMedina Foundation, Technology Park of Health Sciences, 18016 Granada, SpainCardiology Service, Hospital Josep Trueta, University of Girona, 17007 Girona, SpainMedical Science Department, School of Medicine, University of Girona, 17003 Girona, SpainCardiology Department, Hospital Central de la Cruz Roja, 28003 Madrid, SpainCardiology Department, Hospital Central de la Cruz Roja, 28003 Madrid, SpainResearch Unit, Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta del Mar University Hospital, 11009 Cádiz, SpainResearch Unit, Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta del Mar University Hospital, 11009 Cádiz, SpainDilated cardiomyopathy (DCM) is a clinical diagnosis characterized by left ventricular or biventricular dilation and systolic dysfunction. In most cases, DCM is progressive, leading to heart failure (HF) and death. This cardiomyopathy has been considered a common and final phenotype of several entities. DCM occurs when cellular pathways fail to maintain the pumping function. The etiology of this disease encompasses several factors, such as ischemia, infection, autoimmunity, drugs or genetic susceptibility. Although the prognosis has improved in the last few years due to red flag clinical follow-up, early familial diagnosis and ongoing optimization of treatment, due to its heterogeneity, there are no targeted therapies available for DCM based on each etiology. Therefore, a better understanding of the mechanisms underlying the pathophysiology of DCM will provide novel therapeutic strategies against this cardiac disease and their different triggers. MicroRNAs (miRNAs) are a group of small noncoding RNAs that play key roles in post-transcriptional gene silencing by targeting mRNAs for translational repression or, to a lesser extent, degradation. A growing number of studies have demonstrated critical functions of miRNAs in cardiovascular diseases (CVDs), including DCM, by regulating mechanisms that contribute to the progression of the disease. Herein, we summarize the role of miRNAs in inflammation, endoplasmic reticulum (ER) stress, oxidative stress, mitochondrial dysfunction, autophagy, cardiomyocyte apoptosis and fibrosis, exclusively in the context of DCM.https://www.mdpi.com/1422-0067/23/21/13573dilated cardiomyopathymicroRNAinflammationreticulum endoplasmic stressoxidative stressapoptosis |
| spellingShingle | Elena Alonso-Villa Fernando Bonet Francisco Hernandez-Torres Óscar Campuzano Georgia Sarquella-Brugada Maribel Quezada-Feijoo Mónica Ramos Alipio Mangas Rocío Toro The Role of MicroRNAs in Dilated Cardiomyopathy: New Insights for an Old Entity International Journal of Molecular Sciences dilated cardiomyopathy microRNA inflammation reticulum endoplasmic stress oxidative stress apoptosis |
| title | The Role of MicroRNAs in Dilated Cardiomyopathy: New Insights for an Old Entity |
| title_full | The Role of MicroRNAs in Dilated Cardiomyopathy: New Insights for an Old Entity |
| title_fullStr | The Role of MicroRNAs in Dilated Cardiomyopathy: New Insights for an Old Entity |
| title_full_unstemmed | The Role of MicroRNAs in Dilated Cardiomyopathy: New Insights for an Old Entity |
| title_short | The Role of MicroRNAs in Dilated Cardiomyopathy: New Insights for an Old Entity |
| title_sort | role of micrornas in dilated cardiomyopathy new insights for an old entity |
| topic | dilated cardiomyopathy microRNA inflammation reticulum endoplasmic stress oxidative stress apoptosis |
| url | https://www.mdpi.com/1422-0067/23/21/13573 |
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