Intravenous lipid emulsion in treatment of cardiocirculatory disturbances caused by glyphosate-surfactant herbicide poisoning
Introduction. Glyphosate is the first widely used herbicide against weed in genetically modified crops. Though glyphosate itself has a low toxicity, commercial products are more dangerous because of increased toxicity due to surfactants addition. There is no specific antidote for the poison...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2016-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501500020J.pdf |
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| author | Jović-Stošić Jasmina Putić Vesna Perković-Vukčević Nataša Babić Gordana Đorđević Snežana Šegrt Zoran |
| author_facet | Jović-Stošić Jasmina Putić Vesna Perković-Vukčević Nataša Babić Gordana Đorđević Snežana Šegrt Zoran |
| author_sort | Jović-Stošić Jasmina |
| collection | DOAJ |
| description | Introduction. Glyphosate is the first widely used herbicide against weed in
genetically modified crops. Though glyphosate itself has a low toxicity,
commercial products are more dangerous because of increased toxicity due to
surfactants addition. There is no specific antidote for the poisoning with
glyphosate-surfactant (Gly-SH). In recent times, the efficacy of intravenous
lipid emulsion (ILE) administration for the treatment of acute poisoning
caused by Gly- SH has been investigated. Case Report. A 50-year-old man was
admitted 3 hours after self-poisoning with herbicide containing glyphosate
and polyoxyethyleneamine, as a surfactant. On admission, the patient was in a
coma, hypotensive (80/50 mmHg) and without spontaneous breathing.
Electrocardiogram showed widecomplex tachycardia, and arterial blood gas
(ABG) revealed acidosis (pH 7.07). Conventional treatment included mechanical
ventilation, intravenous fluids, bicarbonate and dopamine. As there was no
improvement, ILE was started. The patient received 100 mL of 20% Intralipid®
bolus followed by infusion of 400 mL over 20 minutes. Prior to expiration of
infusion, a gradual rise in blood pressure was noted, and within 2 hours
sinus rhythm was restored. Conclusion. This case report suggests that the use
of ILE may be an additional option for the treatment of cardiocirculatory
disturbances caused by commercial products of glyphosate herbicide. [Projekat
Ministarstva nauke Republike Srbije, br. III4128] |
| first_indexed | 2024-12-10T15:23:36Z |
| format | Article |
| id | doaj.art-90ccce1e5d384d7994238e19c3bf44b5 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 2406-0720 |
| language | English |
| last_indexed | 2024-12-10T15:23:36Z |
| publishDate | 2016-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-90ccce1e5d384d7994238e19c3bf44b52022-12-22T01:43:36ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502406-07202016-01-0173439039210.2298/VSP141017020J0042-84501500020JIntravenous lipid emulsion in treatment of cardiocirculatory disturbances caused by glyphosate-surfactant herbicide poisoningJović-Stošić Jasmina0Putić Vesna1Perković-Vukčević Nataša2Babić Gordana3Đorđević Snežana4Šegrt Zoran5Military Medical Academy, National Poison Control Centre, BelgradeMilitary Medical Academy, National Poison Control Centre, BelgradeMilitary Medical Academy, National Poison Control Centre, BelgradeMilitary Medical Academy, National Poison Control Centre, BelgradeMilitary Medical Academy, National Poison Control Centre, BelgradeMilitary Medical Academy, National Poison Control Centre, BelgradeIntroduction. Glyphosate is the first widely used herbicide against weed in genetically modified crops. Though glyphosate itself has a low toxicity, commercial products are more dangerous because of increased toxicity due to surfactants addition. There is no specific antidote for the poisoning with glyphosate-surfactant (Gly-SH). In recent times, the efficacy of intravenous lipid emulsion (ILE) administration for the treatment of acute poisoning caused by Gly- SH has been investigated. Case Report. A 50-year-old man was admitted 3 hours after self-poisoning with herbicide containing glyphosate and polyoxyethyleneamine, as a surfactant. On admission, the patient was in a coma, hypotensive (80/50 mmHg) and without spontaneous breathing. Electrocardiogram showed widecomplex tachycardia, and arterial blood gas (ABG) revealed acidosis (pH 7.07). Conventional treatment included mechanical ventilation, intravenous fluids, bicarbonate and dopamine. As there was no improvement, ILE was started. The patient received 100 mL of 20% Intralipid® bolus followed by infusion of 400 mL over 20 minutes. Prior to expiration of infusion, a gradual rise in blood pressure was noted, and within 2 hours sinus rhythm was restored. Conclusion. This case report suggests that the use of ILE may be an additional option for the treatment of cardiocirculatory disturbances caused by commercial products of glyphosate herbicide. [Projekat Ministarstva nauke Republike Srbije, br. III4128]http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501500020J.pdfherbicidespoisoningfat emulsions, intravenouscardiovascular systemtreatment outcome |
| spellingShingle | Jović-Stošić Jasmina Putić Vesna Perković-Vukčević Nataša Babić Gordana Đorđević Snežana Šegrt Zoran Intravenous lipid emulsion in treatment of cardiocirculatory disturbances caused by glyphosate-surfactant herbicide poisoning Vojnosanitetski Pregled herbicides poisoning fat emulsions, intravenous cardiovascular system treatment outcome |
| title | Intravenous lipid emulsion in treatment of cardiocirculatory disturbances caused by glyphosate-surfactant herbicide poisoning |
| title_full | Intravenous lipid emulsion in treatment of cardiocirculatory disturbances caused by glyphosate-surfactant herbicide poisoning |
| title_fullStr | Intravenous lipid emulsion in treatment of cardiocirculatory disturbances caused by glyphosate-surfactant herbicide poisoning |
| title_full_unstemmed | Intravenous lipid emulsion in treatment of cardiocirculatory disturbances caused by glyphosate-surfactant herbicide poisoning |
| title_short | Intravenous lipid emulsion in treatment of cardiocirculatory disturbances caused by glyphosate-surfactant herbicide poisoning |
| title_sort | intravenous lipid emulsion in treatment of cardiocirculatory disturbances caused by glyphosate surfactant herbicide poisoning |
| topic | herbicides poisoning fat emulsions, intravenous cardiovascular system treatment outcome |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501500020J.pdf |
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