Alternative splicing of mRNA in colorectal cancer: new strategies for tumor diagnosis and treatment
Abstract Alternative splicing (AS) is an important event that contributes to posttranscriptional gene regulation. This process leads to several mature transcript variants with diverse physiological functions. Indeed, disruption of various aspects of this multistep process, such as cis- or trans- fac...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-07-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-021-04031-w |
| _version_ | 1818357677348093952 |
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| author | Yanyan Chen Mengxi Huang Xiaolong Liu Yadi Huang Chao Liu Jialong Zhu Gongbo Fu Zengjie Lei Xiaoyuan Chu |
| author_facet | Yanyan Chen Mengxi Huang Xiaolong Liu Yadi Huang Chao Liu Jialong Zhu Gongbo Fu Zengjie Lei Xiaoyuan Chu |
| author_sort | Yanyan Chen |
| collection | DOAJ |
| description | Abstract Alternative splicing (AS) is an important event that contributes to posttranscriptional gene regulation. This process leads to several mature transcript variants with diverse physiological functions. Indeed, disruption of various aspects of this multistep process, such as cis- or trans- factor alteration, promotes the progression of colorectal cancer. Therefore, targeting some specific processes of AS may be an effective therapeutic strategy for treating cancer. Here, we provide an overview of the AS events related to colorectal cancer based on research done in the past 5 years. We focus on the mechanisms and functions of variant products of AS that are relevant to malignant hallmarks, with an emphasis on variants with clinical significance. In addition, novel strategies for exploiting the therapeutic value of AS events are discussed. |
| first_indexed | 2024-12-13T20:16:54Z |
| format | Article |
| id | doaj.art-90ceeefbcf9a4f2084068daf9cb42aed |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-12-13T20:16:54Z |
| publishDate | 2021-07-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-90ceeefbcf9a4f2084068daf9cb42aed2022-12-21T23:32:47ZengNature Publishing GroupCell Death and Disease2041-48892021-07-0112811610.1038/s41419-021-04031-wAlternative splicing of mRNA in colorectal cancer: new strategies for tumor diagnosis and treatmentYanyan Chen0Mengxi Huang1Xiaolong Liu2Yadi Huang3Chao Liu4Jialong Zhu5Gongbo Fu6Zengjie Lei7Xiaoyuan Chu8Department of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing UniversityDepartment of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing UniversityDepartment of Cardiothoracic Surgery, Jinling Hospital, Nanjing Medical UniversityDepartment of Medical Oncology, Jinling Hospital, First School of Clinical Medicine, Southern Medical UniversityDepartment of Medical Oncology, Jinling Hospital, Nanjing Medical UniversityDepartment of Medical Oncology, Jinling Hospital, First School of Clinical Medicine, Southern Medical UniversityDepartment of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing UniversityDepartment of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing UniversityDepartment of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing UniversityAbstract Alternative splicing (AS) is an important event that contributes to posttranscriptional gene regulation. This process leads to several mature transcript variants with diverse physiological functions. Indeed, disruption of various aspects of this multistep process, such as cis- or trans- factor alteration, promotes the progression of colorectal cancer. Therefore, targeting some specific processes of AS may be an effective therapeutic strategy for treating cancer. Here, we provide an overview of the AS events related to colorectal cancer based on research done in the past 5 years. We focus on the mechanisms and functions of variant products of AS that are relevant to malignant hallmarks, with an emphasis on variants with clinical significance. In addition, novel strategies for exploiting the therapeutic value of AS events are discussed.https://doi.org/10.1038/s41419-021-04031-w |
| spellingShingle | Yanyan Chen Mengxi Huang Xiaolong Liu Yadi Huang Chao Liu Jialong Zhu Gongbo Fu Zengjie Lei Xiaoyuan Chu Alternative splicing of mRNA in colorectal cancer: new strategies for tumor diagnosis and treatment Cell Death and Disease |
| title | Alternative splicing of mRNA in colorectal cancer: new strategies for tumor diagnosis and treatment |
| title_full | Alternative splicing of mRNA in colorectal cancer: new strategies for tumor diagnosis and treatment |
| title_fullStr | Alternative splicing of mRNA in colorectal cancer: new strategies for tumor diagnosis and treatment |
| title_full_unstemmed | Alternative splicing of mRNA in colorectal cancer: new strategies for tumor diagnosis and treatment |
| title_short | Alternative splicing of mRNA in colorectal cancer: new strategies for tumor diagnosis and treatment |
| title_sort | alternative splicing of mrna in colorectal cancer new strategies for tumor diagnosis and treatment |
| url | https://doi.org/10.1038/s41419-021-04031-w |
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