Factors Affecting Colchicine Adherence in Pediatric Familial Mediterranean Fever
Aim:Familial Mediterranean Fever (FMF) is the most frequent monogenetic autoinflammatory disorder. It is characterized by fever and serositis. The first line treatment of FMF is colchicine. Adherence to colchicine is one of the main factors affecting colchicine response. In this study, we aimed to e...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2023-03-01
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| Series: | Journal of Pediatric Research |
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| Online Access: |
http://jpedres.org/archives/archive-detail/article-preview/factors-affecting-colchicine-adherence-in-pediatri/58754
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| author | Esra Nagehan Akyol Önder Esra Ensari Öznur Bilaç Pelin Ertan |
| author_facet | Esra Nagehan Akyol Önder Esra Ensari Öznur Bilaç Pelin Ertan |
| author_sort | Esra Nagehan Akyol Önder |
| collection | DOAJ |
| description | Aim:Familial Mediterranean Fever (FMF) is the most frequent monogenetic autoinflammatory disorder. It is characterized by fever and serositis. The first line treatment of FMF is colchicine. Adherence to colchicine is one of the main factors affecting colchicine response. In this study, we aimed to evaluate drug adherence in children with FMF using the medication adherence scale in FMF (MASIF). We also assessed the clinical characteristics of drug-adherent patients and factors affecting drug adherence.Materials and Methods:Eighty-two children with FMF under colchicine therapy were included in this cross-sectional observational study. The patients were divided into two groups according to medication adherence and compared according to their demographic and clinical data.Results:According to MASIF, 31 (38%) patients had non-adherence to colchicine. There was a significant difference between the colchicine-adherent and non-adherent groups in terms of age, disease severity according to the International severity score for FMF, attack rate, colchicine dosage, M694V homozygosity, and family type (p=0.005, p=0.04, p=0.025, p=0.045, p=0.04, and p=0.046, respectively).Conclusion:Patients with FMF should be questioned about their medication adherence at every visit, and children with a high risk of colchicine non-adherence should be followed up more closely. |
| first_indexed | 2024-04-10T06:15:19Z |
| format | Article |
| id | doaj.art-90cfd5f65ccd45b49c623edf80d73777 |
| institution | Directory Open Access Journal |
| issn | 2147-9445 2587-2478 |
| language | English |
| last_indexed | 2024-04-10T06:15:19Z |
| publishDate | 2023-03-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Journal of Pediatric Research |
| spelling | doaj.art-90cfd5f65ccd45b49c623edf80d737772023-03-02T08:20:57ZengGalenos YayineviJournal of Pediatric Research2147-94452587-24782023-03-01101879210.4274/jpr.galenos.2023.3443713049054Factors Affecting Colchicine Adherence in Pediatric Familial Mediterranean FeverEsra Nagehan Akyol Önder0Esra Ensari1Öznur Bilaç2Pelin Ertan3 Manisa Celal Bayar University Faculty of Medicine, Department of Pediatric Nephrology, Manisa, Turkey Manisa Celal Bayar University Faculty of Medicine, Department of Pediatric Nephrology, Manisa, Turkey Manisa Celal Bayar University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Manisa, Turkey Manisa Celal Bayar University Faculty of Medicine, Department of Pediatric Nephrology, Manisa, Turkey Aim:Familial Mediterranean Fever (FMF) is the most frequent monogenetic autoinflammatory disorder. It is characterized by fever and serositis. The first line treatment of FMF is colchicine. Adherence to colchicine is one of the main factors affecting colchicine response. In this study, we aimed to evaluate drug adherence in children with FMF using the medication adherence scale in FMF (MASIF). We also assessed the clinical characteristics of drug-adherent patients and factors affecting drug adherence.Materials and Methods:Eighty-two children with FMF under colchicine therapy were included in this cross-sectional observational study. The patients were divided into two groups according to medication adherence and compared according to their demographic and clinical data.Results:According to MASIF, 31 (38%) patients had non-adherence to colchicine. There was a significant difference between the colchicine-adherent and non-adherent groups in terms of age, disease severity according to the International severity score for FMF, attack rate, colchicine dosage, M694V homozygosity, and family type (p=0.005, p=0.04, p=0.025, p=0.045, p=0.04, and p=0.046, respectively).Conclusion:Patients with FMF should be questioned about their medication adherence at every visit, and children with a high risk of colchicine non-adherence should be followed up more closely. http://jpedres.org/archives/archive-detail/article-preview/factors-affecting-colchicine-adherence-in-pediatri/58754 adherencechildrencolchicinefamilial mediterranean fevernon-compliance |
| spellingShingle | Esra Nagehan Akyol Önder Esra Ensari Öznur Bilaç Pelin Ertan Factors Affecting Colchicine Adherence in Pediatric Familial Mediterranean Fever Journal of Pediatric Research adherence children colchicine familial mediterranean fever non-compliance |
| title | Factors Affecting Colchicine Adherence in Pediatric Familial Mediterranean Fever |
| title_full | Factors Affecting Colchicine Adherence in Pediatric Familial Mediterranean Fever |
| title_fullStr | Factors Affecting Colchicine Adherence in Pediatric Familial Mediterranean Fever |
| title_full_unstemmed | Factors Affecting Colchicine Adherence in Pediatric Familial Mediterranean Fever |
| title_short | Factors Affecting Colchicine Adherence in Pediatric Familial Mediterranean Fever |
| title_sort | factors affecting colchicine adherence in pediatric familial mediterranean fever |
| topic | adherence children colchicine familial mediterranean fever non-compliance |
| url |
http://jpedres.org/archives/archive-detail/article-preview/factors-affecting-colchicine-adherence-in-pediatri/58754
|
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