Association of the Risk of Primary Sjögren's Syndrome With Fibrocystic Breast Disease: A Nationwide, Population-Based Study
Objective: Primary Sjögren's syndrome (pSS) is characterized by exocrine glandular inflammation; however, the association between preceding mammary-gland-inflammation-related diseases and newly diagnosed pSS remains unexplored.Methods: We used the 2003–2013 data retrieved from Taiwan's Nat...
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Frontiers Media S.A.
2021-07-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.704593/full |
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| author | Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsian-Min Chen Hsian-Min Chen Hsian-Min Chen Hsian-Min Chen Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Kuo-Tung Tang Kuo-Tung Tang Der-Yuan Chen Der-Yuan Chen Der-Yuan Chen James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei Wen-Cheng Chao Wen-Cheng Chao Wen-Cheng Chao Wen-Cheng Chao |
| author_facet | Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsian-Min Chen Hsian-Min Chen Hsian-Min Chen Hsian-Min Chen Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Kuo-Tung Tang Kuo-Tung Tang Der-Yuan Chen Der-Yuan Chen Der-Yuan Chen James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei Wen-Cheng Chao Wen-Cheng Chao Wen-Cheng Chao Wen-Cheng Chao |
| author_sort | Hsin-Hua Chen |
| collection | DOAJ |
| description | Objective: Primary Sjögren's syndrome (pSS) is characterized by exocrine glandular inflammation; however, the association between preceding mammary-gland-inflammation-related diseases and newly diagnosed pSS remains unexplored.Methods: We used the 2003–2013 data retrieved from Taiwan's National Health Insurance Research Database (NHIRD) to conduct the present population-based study. We identified newly diagnosed pSS female patients during the 2001–2013 period, as well as age-matched (1:20) and propensity-score-matched (1:2) non-SS individuals (as controls). We explored the associations between pSS and a history of mastitis and fibrocystic breast disease by determining adjusted odds ratios (aORs) with 95% confidence intervals (CIs) using a conditional logistical regression analysis after controlling for potential confounders.Results: We identified 9,665 patients with pSS and 193,300 age-matched non-SS controls, as well as 9,155 SS cases and 18,310 propensity-score-matched non-SS controls. We found that fibrocystic breast disease (aOR, 1.75; 95% CI, 1.63–1.88) were independently associated with incident SS, whereas mastitis and childbirth-associated breast infections were not associated with incident SS. We also found positive associations between SS and previously reported SS-associated diseases, including cardiovascular diseases, thyroid diseases, pancreatitis, bronchiectasis, infectious diseases, osteoporosis, and ankylosing spondylitis. In the propensity-score-matched populations, the associations between pSS and fibrocystic breast disease (aOR, 1.74; 95% CI, 1.58–1.91) remained consistent.Conclusion: The present population-based study revealed a previously unexplored association between pSS and history of fibrocystic breast disease, and the finding highlights the need to survey pSS in patients with mammary-gland-inflammation-associated diseases. |
| first_indexed | 2024-12-17T03:17:18Z |
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| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-17T03:17:18Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj.art-90d17407b1284515a8bc90549bf0864a2022-12-21T22:05:37ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-07-01810.3389/fmed.2021.704593704593Association of the Risk of Primary Sjögren's Syndrome With Fibrocystic Breast Disease: A Nationwide, Population-Based StudyHsin-Hua Chen0Hsin-Hua Chen1Hsin-Hua Chen2Hsin-Hua Chen3Hsin-Hua Chen4Hsian-Min Chen5Hsian-Min Chen6Hsian-Min Chen7Hsian-Min Chen8Ching-Heng Lin9Ching-Heng Lin10Ching-Heng Lin11Ching-Heng Lin12Kuo-Tung Tang13Kuo-Tung Tang14Der-Yuan Chen15Der-Yuan Chen16Der-Yuan Chen17James Cheng-Chung Wei18James Cheng-Chung Wei19James Cheng-Chung Wei20Wen-Cheng Chao21Wen-Cheng Chao22Wen-Cheng Chao23Wen-Cheng Chao24Department of Medical Research, Taichung Veterans General Hospital, Taichung, TaiwanDivision of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanInstitute of Biomedical Science and Rong Hsing Research Centre for Translational Medicine, Chung Hsing University, Taichung, TaiwanDepartment of Industrial Engineering and Enterprise Information, Tunghai University, Taichung, TaiwanBig Data Center, Chung Hsing University, Taichung, TaiwanDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, TaiwanInstitute of Biomedical Science and Rong Hsing Research Centre for Translational Medicine, Chung Hsing University, Taichung, TaiwanDepartment of Medical Research, Center for Quantitative Imaging in Medicine, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Computer Science and Information Engineering, National United University, Miaoli, TaiwanDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Industrial Engineering and Enterprise Information, Tunghai University, Taichung, TaiwanDepartment of Healthcare Management, National Taipei University of Nursing and Health Sciences, Taipei, TaiwanDepartment of Public Health, College of Medicine, Fu Jen Catholic University, New Taipei City, TaiwanDivision of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan0Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan1Rheumatology and Immunology Center, China Medical University Hospital, Taichung, Taiwan2School of Medicine, China Medical University, Taichung, Taiwan3Translational Medicine Laboratory, Rheumatology and Immunology Center, China Medical University Hospital, Taichung, Taiwan4Division of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan5Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan6Institute of Integrative Medicine, China Medical University, Taichung, TaiwanBig Data Center, Chung Hsing University, Taichung, Taiwan7Department of Critical Care Medicine, Taichung Veterans General Hospital, Taichung, Taiwan8Department of Computer Science, Tunghai University, Taichung, Taiwan9Department of Automatic Control Engineering, College of Information and Electrical Engineering, Feng Chia University, Taichung, TaiwanObjective: Primary Sjögren's syndrome (pSS) is characterized by exocrine glandular inflammation; however, the association between preceding mammary-gland-inflammation-related diseases and newly diagnosed pSS remains unexplored.Methods: We used the 2003–2013 data retrieved from Taiwan's National Health Insurance Research Database (NHIRD) to conduct the present population-based study. We identified newly diagnosed pSS female patients during the 2001–2013 period, as well as age-matched (1:20) and propensity-score-matched (1:2) non-SS individuals (as controls). We explored the associations between pSS and a history of mastitis and fibrocystic breast disease by determining adjusted odds ratios (aORs) with 95% confidence intervals (CIs) using a conditional logistical regression analysis after controlling for potential confounders.Results: We identified 9,665 patients with pSS and 193,300 age-matched non-SS controls, as well as 9,155 SS cases and 18,310 propensity-score-matched non-SS controls. We found that fibrocystic breast disease (aOR, 1.75; 95% CI, 1.63–1.88) were independently associated with incident SS, whereas mastitis and childbirth-associated breast infections were not associated with incident SS. We also found positive associations between SS and previously reported SS-associated diseases, including cardiovascular diseases, thyroid diseases, pancreatitis, bronchiectasis, infectious diseases, osteoporosis, and ankylosing spondylitis. In the propensity-score-matched populations, the associations between pSS and fibrocystic breast disease (aOR, 1.74; 95% CI, 1.58–1.91) remained consistent.Conclusion: The present population-based study revealed a previously unexplored association between pSS and history of fibrocystic breast disease, and the finding highlights the need to survey pSS in patients with mammary-gland-inflammation-associated diseases.https://www.frontiersin.org/articles/10.3389/fmed.2021.704593/fullSjögren's syndromemammary glandmastitisfibrocystic breast diseaseepidemiology |
| spellingShingle | Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsin-Hua Chen Hsian-Min Chen Hsian-Min Chen Hsian-Min Chen Hsian-Min Chen Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Ching-Heng Lin Kuo-Tung Tang Kuo-Tung Tang Der-Yuan Chen Der-Yuan Chen Der-Yuan Chen James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei Wen-Cheng Chao Wen-Cheng Chao Wen-Cheng Chao Wen-Cheng Chao Association of the Risk of Primary Sjögren's Syndrome With Fibrocystic Breast Disease: A Nationwide, Population-Based Study Frontiers in Medicine Sjögren's syndrome mammary gland mastitis fibrocystic breast disease epidemiology |
| title | Association of the Risk of Primary Sjögren's Syndrome With Fibrocystic Breast Disease: A Nationwide, Population-Based Study |
| title_full | Association of the Risk of Primary Sjögren's Syndrome With Fibrocystic Breast Disease: A Nationwide, Population-Based Study |
| title_fullStr | Association of the Risk of Primary Sjögren's Syndrome With Fibrocystic Breast Disease: A Nationwide, Population-Based Study |
| title_full_unstemmed | Association of the Risk of Primary Sjögren's Syndrome With Fibrocystic Breast Disease: A Nationwide, Population-Based Study |
| title_short | Association of the Risk of Primary Sjögren's Syndrome With Fibrocystic Breast Disease: A Nationwide, Population-Based Study |
| title_sort | association of the risk of primary sjogren s syndrome with fibrocystic breast disease a nationwide population based study |
| topic | Sjögren's syndrome mammary gland mastitis fibrocystic breast disease epidemiology |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.704593/full |
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