Efficacy of Antimicrobial Photodynamic Therapy Mediated by Photosensitizers Conjugated with Inorganic Nanoparticles: Systematic Review and Meta-Analysis
Antimicrobial photodynamic therapy (aPDT) is a method that does not seem to promote antimicrobial resistance. Photosensitizers (PS) conjugated with inorganic nanoparticles for the drug-delivery system have the purpose of enhancing the efficacy of aPDT. The present study was to perform a systematic r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/10/2050 |
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| author | Túlio Morandin Ferrisse Luana Mendonça Dias Analú Barros de Oliveira Cláudia Carolina Jordão Ewerton Garcia de Oliveira Mima Ana Claudia Pavarina |
| author_facet | Túlio Morandin Ferrisse Luana Mendonça Dias Analú Barros de Oliveira Cláudia Carolina Jordão Ewerton Garcia de Oliveira Mima Ana Claudia Pavarina |
| author_sort | Túlio Morandin Ferrisse |
| collection | DOAJ |
| description | Antimicrobial photodynamic therapy (aPDT) is a method that does not seem to promote antimicrobial resistance. Photosensitizers (PS) conjugated with inorganic nanoparticles for the drug-delivery system have the purpose of enhancing the efficacy of aPDT. The present study was to perform a systematic review and meta-analysis of the efficacy of aPDT mediated by PS conjugated with inorganic nanoparticles. The PubMed, Scopus, Web of Science, Science Direct, Cochrane Library, SciELO, and Lilacs databases were searched. OHAT Rob toll was used to assess the risk of bias. A random effect model with an odds ratio (OR) and effect measure was used. Fourteen articles were able to be included in the present review. The most frequent microorganisms evaluated were <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>, and metallic and silica nanoparticles were the most common drug-delivery systems associated with PS. Articles showed biases related to blinding. Significant results were found in aPDT mediated by PS conjugated with inorganic nanoparticles for overall reduction of microorganism cultured in suspension (OR = 0.19 [0.07; 0.67]/<i>p</i>-value = 0.0019), <i>E. coli</i> (OR = 0.08 [0.01; 0.52]/<i>p</i>-value = 0.0081), and for Gram-negative bacteria (OR = 0.12 [0.02; 0.56/<i>p</i>-value = 0.0071). This association approach significantly improved the efficacy in the reduction of microbial cells. However, additional blinding studies evaluating the efficacy of this therapy over microorganisms cultured in biofilm are required. |
| first_indexed | 2024-03-09T19:35:45Z |
| format | Article |
| id | doaj.art-90d1c768b38343b5b711a2969819c3c6 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T19:35:45Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-90d1c768b38343b5b711a2969819c3c62023-11-24T01:54:46ZengMDPI AGPharmaceutics1999-49232022-09-011410205010.3390/pharmaceutics14102050Efficacy of Antimicrobial Photodynamic Therapy Mediated by Photosensitizers Conjugated with Inorganic Nanoparticles: Systematic Review and Meta-AnalysisTúlio Morandin Ferrisse0Luana Mendonça Dias1Analú Barros de Oliveira2Cláudia Carolina Jordão3Ewerton Garcia de Oliveira Mima4Ana Claudia Pavarina5Department of Dental Materials and Prosthodontics, School of Dentistry at Araraquara, Universidade Estadual Paulista (UNESP), Araraquara 14801-903, SP, BrazilDepartment of Dental Materials and Prosthodontics, School of Dentistry at Araraquara, Universidade Estadual Paulista (UNESP), Araraquara 14801-903, SP, BrazilDepartment of Morphology, Pediatric Dentistry and Orthodontic, School of Dentistry, São Paulo State University (UNESP), Araraquara 14801-903, SP, BrazilDepartment of Dental Materials and Prosthodontics, School of Dentistry at Araraquara, Universidade Estadual Paulista (UNESP), Araraquara 14801-903, SP, BrazilDepartment of Dental Materials and Prosthodontics, School of Dentistry at Araraquara, Universidade Estadual Paulista (UNESP), Araraquara 14801-903, SP, BrazilDepartment of Dental Materials and Prosthodontics, School of Dentistry at Araraquara, Universidade Estadual Paulista (UNESP), Araraquara 14801-903, SP, BrazilAntimicrobial photodynamic therapy (aPDT) is a method that does not seem to promote antimicrobial resistance. Photosensitizers (PS) conjugated with inorganic nanoparticles for the drug-delivery system have the purpose of enhancing the efficacy of aPDT. The present study was to perform a systematic review and meta-analysis of the efficacy of aPDT mediated by PS conjugated with inorganic nanoparticles. The PubMed, Scopus, Web of Science, Science Direct, Cochrane Library, SciELO, and Lilacs databases were searched. OHAT Rob toll was used to assess the risk of bias. A random effect model with an odds ratio (OR) and effect measure was used. Fourteen articles were able to be included in the present review. The most frequent microorganisms evaluated were <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>, and metallic and silica nanoparticles were the most common drug-delivery systems associated with PS. Articles showed biases related to blinding. Significant results were found in aPDT mediated by PS conjugated with inorganic nanoparticles for overall reduction of microorganism cultured in suspension (OR = 0.19 [0.07; 0.67]/<i>p</i>-value = 0.0019), <i>E. coli</i> (OR = 0.08 [0.01; 0.52]/<i>p</i>-value = 0.0081), and for Gram-negative bacteria (OR = 0.12 [0.02; 0.56/<i>p</i>-value = 0.0071). This association approach significantly improved the efficacy in the reduction of microbial cells. However, additional blinding studies evaluating the efficacy of this therapy over microorganisms cultured in biofilm are required.https://www.mdpi.com/1999-4923/14/10/2050antimicrobial photodynamic therapyinorganic nanoparticlesdrug-delivery system<i>Staphylococcus aureus</i><i>Escherichia coli</i>systematic review |
| spellingShingle | Túlio Morandin Ferrisse Luana Mendonça Dias Analú Barros de Oliveira Cláudia Carolina Jordão Ewerton Garcia de Oliveira Mima Ana Claudia Pavarina Efficacy of Antimicrobial Photodynamic Therapy Mediated by Photosensitizers Conjugated with Inorganic Nanoparticles: Systematic Review and Meta-Analysis Pharmaceutics antimicrobial photodynamic therapy inorganic nanoparticles drug-delivery system <i>Staphylococcus aureus</i> <i>Escherichia coli</i> systematic review |
| title | Efficacy of Antimicrobial Photodynamic Therapy Mediated by Photosensitizers Conjugated with Inorganic Nanoparticles: Systematic Review and Meta-Analysis |
| title_full | Efficacy of Antimicrobial Photodynamic Therapy Mediated by Photosensitizers Conjugated with Inorganic Nanoparticles: Systematic Review and Meta-Analysis |
| title_fullStr | Efficacy of Antimicrobial Photodynamic Therapy Mediated by Photosensitizers Conjugated with Inorganic Nanoparticles: Systematic Review and Meta-Analysis |
| title_full_unstemmed | Efficacy of Antimicrobial Photodynamic Therapy Mediated by Photosensitizers Conjugated with Inorganic Nanoparticles: Systematic Review and Meta-Analysis |
| title_short | Efficacy of Antimicrobial Photodynamic Therapy Mediated by Photosensitizers Conjugated with Inorganic Nanoparticles: Systematic Review and Meta-Analysis |
| title_sort | efficacy of antimicrobial photodynamic therapy mediated by photosensitizers conjugated with inorganic nanoparticles systematic review and meta analysis |
| topic | antimicrobial photodynamic therapy inorganic nanoparticles drug-delivery system <i>Staphylococcus aureus</i> <i>Escherichia coli</i> systematic review |
| url | https://www.mdpi.com/1999-4923/14/10/2050 |
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