In silico clinical trial evaluating lisdexamfetamine’s and methylphenidate’s mechanism of action computational models in an attention-deficit/hyperactivity disorder virtual patients’ population

In silico clinical trial evaluating lisdexamfetamine’s and methylphenidate’s mechanism of action computational models in an attention-deficit/hyperactivity disorder virtual patients’ population

IntroductionAttention-deficit/hyperactivity disorder (ADHD) is an impairing psychiatric condition with the stimulants, lisdexamfetamine (LDX), and methylphenidate (MPH), as the first lines pharmacological treatment.MethodsHerein, we applied a novel in silico method to evaluate virtual LDX (vLDX) and...

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Bibliographic Details
Main Authors: José Ramón Gutiérrez-Casares, Javier Quintero, Cristina Segú-Vergés, Pilar Rodríguez Monterde, Tamara Pozo-Rubio, Mireia Coma, Carmen Montoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Psychiatry
Subjects:
attention-deficit/hyperactivity disorder
lisdexamfetamine
methylphenidate
mathematical modeling
in silico clinical trial
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2023.939650/full

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