USE OF SILDENAFIL (VIAGRA®) FOR ERECTILE DYSFUNCTION IN DIALYSIS PATIENTS – OUR FIRST EXPERIENCE
<p>Background. Male patients with end stage renal disease often report erectile dysfunction, which is very common especially in younger males. Impotence is reported to exceed 50% in male chronic renal failure patients, and is present in 65% of such patients undergoing hemodialysis. Numerous et...
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| Format: | Article |
| Language: | English |
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Slovenian Medical Association
2002-01-01
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| Series: | Zdravniški Vestnik |
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| Online Access: | http://vestnik.szd.si/index.php/ZdravVest/article/view/1559 |
| _version_ | 1828850745010552832 |
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| author | Bojan Vujkovac Nado Vodopija Janez Lavre |
| author_facet | Bojan Vujkovac Nado Vodopija Janez Lavre |
| author_sort | Bojan Vujkovac |
| collection | DOAJ |
| description | <p>Background. Male patients with end stage renal disease often report erectile dysfunction, which is very common especially in younger males. Impotence is reported to exceed 50% in male chronic renal failure patients, and is present in 65% of such patients undergoing hemodialysis. Numerous etiological factors have been reported as possible cause for sexual dysfunction. Sildenafil (Viagra®), a potent specific inhibitor of cGMP phosphodiesterase, was used in this case study to improve erectile dysfunction in dialysis male patients.</p><p>Methods and results. During 12 weeks we treated 4 dialysis patients. 2 patients were treated with peritoneal dialysis and 2 patients were in the program of chronic hemodialysis. All patients were in the program of dialysis for more than 24 months, and reported erectile dysfunction and impotence after they had started with dialysis treatment. Sildenafil was used in the treatment. The dosage schedule for sildenafil was 50mg/ week orally for 2 weeks followed by 100 mg/week for the next 10 weeks if there was no effect on initial dosage. Efficacy of treatment was evaluated by means of the International Index of Erectile Dysfunction. All 4 patients reported no significant effect on initial dose. With higher dose of sildenafil treatment was overwhelmingly successful, with reported prolonged improvement of erectile dysfunction for 42 to 72 hours. Side effects were present only in 1 patient who had severe headaches after higher dose. No patients experienced priapism.</p><p>Conclusions. There have been only few reports in the literature on the use of sildenafil in dialysis patients. Our small case study suggests that sildenafil could be successfully and safely used for treatment of erectile dysfunction also in dialysis patients. A large trial would be necessary to confirm the efficacy of the drug for this specific group of patients.<br /><br /></p> |
| first_indexed | 2024-12-12T23:18:17Z |
| format | Article |
| id | doaj.art-90d3e958d4a243d7a9967076cd62163d |
| institution | Directory Open Access Journal |
| issn | 1318-0347 1581-0224 |
| language | English |
| last_indexed | 2024-12-12T23:18:17Z |
| publishDate | 2002-01-01 |
| publisher | Slovenian Medical Association |
| record_format | Article |
| series | Zdravniški Vestnik |
| spelling | doaj.art-90d3e958d4a243d7a9967076cd62163d2022-12-22T00:08:22ZengSlovenian Medical AssociationZdravniški Vestnik1318-03471581-02242002-01-017111099USE OF SILDENAFIL (VIAGRA®) FOR ERECTILE DYSFUNCTION IN DIALYSIS PATIENTS – OUR FIRST EXPERIENCEBojan Vujkovac0Nado Vodopija1Janez Lavre2Center za dializo Splošna bolnišnica Gosposvetska c. 1 2380 Slovenj GradecUrološki oddelek Splošna bolnišnica Gosposvetska c. 1 2380 Slovenj GradecInterni oddelek Splošna bolnišnica Gosposvetska c. 1 2380 Slovenj Gradec<p>Background. Male patients with end stage renal disease often report erectile dysfunction, which is very common especially in younger males. Impotence is reported to exceed 50% in male chronic renal failure patients, and is present in 65% of such patients undergoing hemodialysis. Numerous etiological factors have been reported as possible cause for sexual dysfunction. Sildenafil (Viagra®), a potent specific inhibitor of cGMP phosphodiesterase, was used in this case study to improve erectile dysfunction in dialysis male patients.</p><p>Methods and results. During 12 weeks we treated 4 dialysis patients. 2 patients were treated with peritoneal dialysis and 2 patients were in the program of chronic hemodialysis. All patients were in the program of dialysis for more than 24 months, and reported erectile dysfunction and impotence after they had started with dialysis treatment. Sildenafil was used in the treatment. The dosage schedule for sildenafil was 50mg/ week orally for 2 weeks followed by 100 mg/week for the next 10 weeks if there was no effect on initial dosage. Efficacy of treatment was evaluated by means of the International Index of Erectile Dysfunction. All 4 patients reported no significant effect on initial dose. With higher dose of sildenafil treatment was overwhelmingly successful, with reported prolonged improvement of erectile dysfunction for 42 to 72 hours. Side effects were present only in 1 patient who had severe headaches after higher dose. No patients experienced priapism.</p><p>Conclusions. There have been only few reports in the literature on the use of sildenafil in dialysis patients. Our small case study suggests that sildenafil could be successfully and safely used for treatment of erectile dysfunction also in dialysis patients. A large trial would be necessary to confirm the efficacy of the drug for this specific group of patients.<br /><br /></p>http://vestnik.szd.si/index.php/ZdravVest/article/view/1559erectile dysfunctionhemodialysisCAPDsildenafil |
| spellingShingle | Bojan Vujkovac Nado Vodopija Janez Lavre USE OF SILDENAFIL (VIAGRA®) FOR ERECTILE DYSFUNCTION IN DIALYSIS PATIENTS – OUR FIRST EXPERIENCE Zdravniški Vestnik erectile dysfunction hemodialysis CAPD sildenafil |
| title | USE OF SILDENAFIL (VIAGRA®) FOR ERECTILE DYSFUNCTION IN DIALYSIS PATIENTS – OUR FIRST EXPERIENCE |
| title_full | USE OF SILDENAFIL (VIAGRA®) FOR ERECTILE DYSFUNCTION IN DIALYSIS PATIENTS – OUR FIRST EXPERIENCE |
| title_fullStr | USE OF SILDENAFIL (VIAGRA®) FOR ERECTILE DYSFUNCTION IN DIALYSIS PATIENTS – OUR FIRST EXPERIENCE |
| title_full_unstemmed | USE OF SILDENAFIL (VIAGRA®) FOR ERECTILE DYSFUNCTION IN DIALYSIS PATIENTS – OUR FIRST EXPERIENCE |
| title_short | USE OF SILDENAFIL (VIAGRA®) FOR ERECTILE DYSFUNCTION IN DIALYSIS PATIENTS – OUR FIRST EXPERIENCE |
| title_sort | use of sildenafil viagra r for erectile dysfunction in dialysis patients our first experience |
| topic | erectile dysfunction hemodialysis CAPD sildenafil |
| url | http://vestnik.szd.si/index.php/ZdravVest/article/view/1559 |
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