Repetitive Transcranial Magnetic Stimulation in Delirium: A Double-blind, Randomized, Sham-controlled, Pilot Study
Introduction: Delirium is a fatal but potentially reversible disorder of the central nervous system that imposes high costs on health systems. This study aims to evaluate the effect of intermittent theta-burst stimulation on the severity and course of delirium disorder. Methods: This is a double-bli...
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2022-03-01
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| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.iums.ac.ir/article-1-1503-en.html |
| _version_ | 1797281000505475072 |
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| author | Emad Yaghoubi Seyed Vahid Shariat Vahid Rashedi Atefeh Ghanbari Jolfaei |
| author_facet | Emad Yaghoubi Seyed Vahid Shariat Vahid Rashedi Atefeh Ghanbari Jolfaei |
| author_sort | Emad Yaghoubi |
| collection | DOAJ |
| description | Introduction: Delirium is a fatal but potentially reversible disorder of the central nervous system that imposes high costs on health systems. This study aims to evaluate the effect of intermittent theta-burst stimulation on the severity and course of delirium disorder.
Methods: This is a double-blind, randomized, sham-controlled pilot study. The study participants were randomly allocated into the active (active intermittent theta-burst stimulation) and sham groups. The severity of delirium was assessed 15 minutes before the intervention and 15 minutes after that by the Neelon and Champagne (NEECHAM) confusion scale.
Results: In the active group, total and subscale scores of NEECHAM significantly decreased after intervention (P<0.05). Although no statistical difference was found in the control group regarding the subscale scores of NEECHAM, the difference in the total scores before and after the sham intervention was statistically significant.
Conclusion: Carrying one session of repetitive transcranial magnetic stimulation on the left dorsolateral prefrontal cortex can reduce the delirium severity in a short period, although it will not decrease the number of delirium cases three days after the intervention. |
| first_indexed | 2024-03-07T16:49:15Z |
| format | Article |
| id | doaj.art-90d4afe443c842fa9f2a730521421649 |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T16:49:15Z |
| publishDate | 2022-03-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-90d4afe443c842fa9f2a7305214216492024-03-03T05:36:52ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422022-03-01132237246Repetitive Transcranial Magnetic Stimulation in Delirium: A Double-blind, Randomized, Sham-controlled, Pilot StudyEmad Yaghoubi0Seyed Vahid Shariat1Vahid Rashedi2Atefeh Ghanbari Jolfaei3 Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Mental Health Research Center, Iran University of Medical Sciences, Tehran, Iran. School of Behavioral Sciences and Mental Health (Tehran Institute of Psychiatry), Iran University of Medical Sciences, Tehran, Iran. Mental Health Research Center, Iran University of Medical Sciences, Tehran, Iran. Introduction: Delirium is a fatal but potentially reversible disorder of the central nervous system that imposes high costs on health systems. This study aims to evaluate the effect of intermittent theta-burst stimulation on the severity and course of delirium disorder. Methods: This is a double-blind, randomized, sham-controlled pilot study. The study participants were randomly allocated into the active (active intermittent theta-burst stimulation) and sham groups. The severity of delirium was assessed 15 minutes before the intervention and 15 minutes after that by the Neelon and Champagne (NEECHAM) confusion scale. Results: In the active group, total and subscale scores of NEECHAM significantly decreased after intervention (P<0.05). Although no statistical difference was found in the control group regarding the subscale scores of NEECHAM, the difference in the total scores before and after the sham intervention was statistically significant. Conclusion: Carrying one session of repetitive transcranial magnetic stimulation on the left dorsolateral prefrontal cortex can reduce the delirium severity in a short period, although it will not decrease the number of delirium cases three days after the intervention.http://bcn.iums.ac.ir/article-1-1503-en.htmldeliriumrepetitive transcranial magnetic stimulation (rtms)randomized controlled trial |
| spellingShingle | Emad Yaghoubi Seyed Vahid Shariat Vahid Rashedi Atefeh Ghanbari Jolfaei Repetitive Transcranial Magnetic Stimulation in Delirium: A Double-blind, Randomized, Sham-controlled, Pilot Study Basic and Clinical Neuroscience delirium repetitive transcranial magnetic stimulation (rtms) randomized controlled trial |
| title | Repetitive Transcranial Magnetic Stimulation in Delirium: A Double-blind, Randomized, Sham-controlled, Pilot Study |
| title_full | Repetitive Transcranial Magnetic Stimulation in Delirium: A Double-blind, Randomized, Sham-controlled, Pilot Study |
| title_fullStr | Repetitive Transcranial Magnetic Stimulation in Delirium: A Double-blind, Randomized, Sham-controlled, Pilot Study |
| title_full_unstemmed | Repetitive Transcranial Magnetic Stimulation in Delirium: A Double-blind, Randomized, Sham-controlled, Pilot Study |
| title_short | Repetitive Transcranial Magnetic Stimulation in Delirium: A Double-blind, Randomized, Sham-controlled, Pilot Study |
| title_sort | repetitive transcranial magnetic stimulation in delirium a double blind randomized sham controlled pilot study |
| topic | delirium repetitive transcranial magnetic stimulation (rtms) randomized controlled trial |
| url | http://bcn.iums.ac.ir/article-1-1503-en.html |
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