Impact of time-of-flight PET on quantification accuracy and lesion detection in simultaneous 18F-choline PET/MRI for prostate cancer
Abstract Background Accurate attenuation correction (AC) is an inherent problem of positron emission tomography magnetic resonance imaging (PET/MRI) systems. Simulation studies showed that time-of-flight (TOF) detectors can reduce PET quantification errors in MRI-based AC. However, its impact on les...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018-05-01
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| Series: | EJNMMI Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13550-018-0390-8 |
| _version_ | 1811192537070698496 |
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| author | Urs J. Muehlematter Hannes W. Nagel Anton Becker Julian Mueller Kerstin N. Vokinger Felipe de Galiza Barbosa Edwin E. G. T. ter Voert Patrick Veit-Haibach Irene A. Burger |
| author_facet | Urs J. Muehlematter Hannes W. Nagel Anton Becker Julian Mueller Kerstin N. Vokinger Felipe de Galiza Barbosa Edwin E. G. T. ter Voert Patrick Veit-Haibach Irene A. Burger |
| author_sort | Urs J. Muehlematter |
| collection | DOAJ |
| description | Abstract Background Accurate attenuation correction (AC) is an inherent problem of positron emission tomography magnetic resonance imaging (PET/MRI) systems. Simulation studies showed that time-of-flight (TOF) detectors can reduce PET quantification errors in MRI-based AC. However, its impact on lesion detection in a clinical setting with 18F-choline has not yet been evaluated. Therefore, we compared TOF and non-TOF 18F-choline PET for absolute and relative difference in standard uptake values (SUV) and investigated the detection rate of metastases in prostate cancer patients. Results Non-TOF SUV was significantly lower compared to TOF in all osseous structures, except the skull, in primary lesions of the prostate, and in pelvic nodal and osseous metastasis. Concerning lymph node metastases, both experienced readers detected 16/19 (84%) on TOF PET, whereas on non-TOF PET readers 1 and 2 detected 11 (58%), and 14 (73%), respectively. With TOF PET readers 1 and 2 detected 14/15 (93%) and 11/15 (73%) bone metastases, respectively, whereas detection rate with non-TOF PET was 73% (11/15) for reader 1 and 53% (8/15) for reader 2. The interreader agreement was good for osseous metastasis detection on TOF (kappa 0.636, 95% confidence interval [CI] 0.453–0.810) and moderate on non-TOF (kappa = 0.600, CI 0.438–0.780). Conclusion TOF reconstruction for 18F-choline PET/MRI shows higher SUV measurements compared to non-TOF reconstructions in physiological osseous structures as well as pelvic malignancies. Our results suggest that addition of TOF information has a positive impact on lesion detection rate for lymph node and bone metastasis in prostate cancer patients. |
| first_indexed | 2024-04-11T23:54:17Z |
| format | Article |
| id | doaj.art-90d517e149524674b9dae621b85c240f |
| institution | Directory Open Access Journal |
| issn | 2191-219X |
| language | English |
| last_indexed | 2024-04-11T23:54:17Z |
| publishDate | 2018-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Research |
| spelling | doaj.art-90d517e149524674b9dae621b85c240f2022-12-22T03:56:24ZengSpringerOpenEJNMMI Research2191-219X2018-05-018111210.1186/s13550-018-0390-8Impact of time-of-flight PET on quantification accuracy and lesion detection in simultaneous 18F-choline PET/MRI for prostate cancerUrs J. Muehlematter0Hannes W. Nagel1Anton Becker2Julian Mueller3Kerstin N. Vokinger4Felipe de Galiza Barbosa5Edwin E. G. T. ter Voert6Patrick Veit-Haibach7Irene A. Burger8Department of Diagnostic and Interventional Radiology, University Hospital ZurichDepartment of Diagnostic and Interventional Radiology, University Hospital ZurichDepartment of Diagnostic and Interventional Radiology, University Hospital ZurichDepartment of Nuclear Medicine, University Hospital ZurichUniversity Hospital ZurichDepartment of Diagnostic Imaging, Sirio Libanes HospitalDepartment of Nuclear Medicine, University Hospital ZurichDepartment Joint Medical Imaging, Toronto General HospitalDepartment of Diagnostic and Interventional Radiology, University Hospital ZurichAbstract Background Accurate attenuation correction (AC) is an inherent problem of positron emission tomography magnetic resonance imaging (PET/MRI) systems. Simulation studies showed that time-of-flight (TOF) detectors can reduce PET quantification errors in MRI-based AC. However, its impact on lesion detection in a clinical setting with 18F-choline has not yet been evaluated. Therefore, we compared TOF and non-TOF 18F-choline PET for absolute and relative difference in standard uptake values (SUV) and investigated the detection rate of metastases in prostate cancer patients. Results Non-TOF SUV was significantly lower compared to TOF in all osseous structures, except the skull, in primary lesions of the prostate, and in pelvic nodal and osseous metastasis. Concerning lymph node metastases, both experienced readers detected 16/19 (84%) on TOF PET, whereas on non-TOF PET readers 1 and 2 detected 11 (58%), and 14 (73%), respectively. With TOF PET readers 1 and 2 detected 14/15 (93%) and 11/15 (73%) bone metastases, respectively, whereas detection rate with non-TOF PET was 73% (11/15) for reader 1 and 53% (8/15) for reader 2. The interreader agreement was good for osseous metastasis detection on TOF (kappa 0.636, 95% confidence interval [CI] 0.453–0.810) and moderate on non-TOF (kappa = 0.600, CI 0.438–0.780). Conclusion TOF reconstruction for 18F-choline PET/MRI shows higher SUV measurements compared to non-TOF reconstructions in physiological osseous structures as well as pelvic malignancies. Our results suggest that addition of TOF information has a positive impact on lesion detection rate for lymph node and bone metastasis in prostate cancer patients.http://link.springer.com/article/10.1186/s13550-018-0390-8PET/MRIAttenuation correctionTime-of-flightProstate cancer |
| spellingShingle | Urs J. Muehlematter Hannes W. Nagel Anton Becker Julian Mueller Kerstin N. Vokinger Felipe de Galiza Barbosa Edwin E. G. T. ter Voert Patrick Veit-Haibach Irene A. Burger Impact of time-of-flight PET on quantification accuracy and lesion detection in simultaneous 18F-choline PET/MRI for prostate cancer EJNMMI Research PET/MRI Attenuation correction Time-of-flight Prostate cancer |
| title | Impact of time-of-flight PET on quantification accuracy and lesion detection in simultaneous 18F-choline PET/MRI for prostate cancer |
| title_full | Impact of time-of-flight PET on quantification accuracy and lesion detection in simultaneous 18F-choline PET/MRI for prostate cancer |
| title_fullStr | Impact of time-of-flight PET on quantification accuracy and lesion detection in simultaneous 18F-choline PET/MRI for prostate cancer |
| title_full_unstemmed | Impact of time-of-flight PET on quantification accuracy and lesion detection in simultaneous 18F-choline PET/MRI for prostate cancer |
| title_short | Impact of time-of-flight PET on quantification accuracy and lesion detection in simultaneous 18F-choline PET/MRI for prostate cancer |
| title_sort | impact of time of flight pet on quantification accuracy and lesion detection in simultaneous 18f choline pet mri for prostate cancer |
| topic | PET/MRI Attenuation correction Time-of-flight Prostate cancer |
| url | http://link.springer.com/article/10.1186/s13550-018-0390-8 |
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