Desflurane anesthesia worsens emergence agitation in adult patients undergoing thyroid surgery compared to sevoflurane anesthesia
Abstract Background The effect of volatile anesthetics on emergence agitation in adults remains unclear. We compared the degree of emergence agitation between desflurane and sevoflurane anesthesia in adults undergoing thyroid surgery. Findings One hundred and sixteen patients with American Society o...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2017-06-01
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| Series: | JA Clinical Reports |
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| Online Access: | http://link.springer.com/article/10.1186/s40981-017-0106-5 |
| _version_ | 1819118376820146176 |
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| author | Takeshi Suzuki Takuya Kurazumi Tomomi Ueda Hiromasa Nagata Takashige Yamada Shizuko Kosugi Saori Hashiguchi Koichi Ito Hiroshi Morisaki |
| author_facet | Takeshi Suzuki Takuya Kurazumi Tomomi Ueda Hiromasa Nagata Takashige Yamada Shizuko Kosugi Saori Hashiguchi Koichi Ito Hiroshi Morisaki |
| author_sort | Takeshi Suzuki |
| collection | DOAJ |
| description | Abstract Background The effect of volatile anesthetics on emergence agitation in adults remains unclear. We compared the degree of emergence agitation between desflurane and sevoflurane anesthesia in adults undergoing thyroid surgery. Findings One hundred and sixteen patients with American Society of Anesthesiologists status 1 or 2 were randomized into two groups: the desflurane group (group D) and the sevoflurane group (group S). After induction of anesthesia with fentanyl (1–2 μg/kg) and propofol (1.5–2.5 mg/kg), tracheal intubation was facilitated with suxamethonium (0.5–1.0 mg/kg). In group D, anesthesia was maintained with desflurane in 66% nitrous oxide and 33% oxygen supplemented with fentanyl when necessary; in group S, sevoflurane was used instead of desflurane. After the end of the surgery, emergence agitation was evaluated with a modified pediatric anesthesia emergence delirium scale (ranging from 0 to 16, with higher scores indicating more severe emergence agitation) before extubation. Time to extubation from the end of the surgery, postoperative pain (evaluated by a numerical rating scale [NRS]), and postoperative nausea and vomiting (PONV) after surgery were examined. The degree of emergence agitation was more severe in group D than in group S (median [interquartile range]: 5 [4–7] vs 4 [2–6], p = 0.008). Time to extubation, NRS scores, and PONV rates were similar between the two groups. Conclusions Desflurane anesthesia worsened emergence agitation as compared with sevoflurane in adult patients undergoing thyroid surgery, but did not affect time to extubation, postoperative pain, or PONV. Trial registration UMIN000014215 |
| first_indexed | 2024-12-22T05:47:54Z |
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| id | doaj.art-90d55fa71b124da7acdbf91c05c8a013 |
| institution | Directory Open Access Journal |
| issn | 2363-9024 |
| language | English |
| last_indexed | 2024-12-22T05:47:54Z |
| publishDate | 2017-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | JA Clinical Reports |
| spelling | doaj.art-90d55fa71b124da7acdbf91c05c8a0132022-12-21T18:36:57ZengSpringerOpenJA Clinical Reports2363-90242017-06-01311610.1186/s40981-017-0106-5Desflurane anesthesia worsens emergence agitation in adult patients undergoing thyroid surgery compared to sevoflurane anesthesiaTakeshi Suzuki0Takuya Kurazumi1Tomomi Ueda2Hiromasa Nagata3Takashige Yamada4Shizuko Kosugi5Saori Hashiguchi6Koichi Ito7Hiroshi Morisaki8Department of Anesthesiology, Keio University School of MedicineDepartment of Anesthesiology, Keio University School of MedicineDepartment of Anesthesiology, Keio University School of MedicineDepartment of Anesthesiology, Keio University School of MedicineDepartment of Anesthesiology, Keio University School of MedicineDepartment of Anesthesiology, Keio University School of MedicineDepartment of Anesthesiology, Keio University School of MedicineDepartment of Surgery, Ito HospitalDepartment of Anesthesiology, Keio University School of MedicineAbstract Background The effect of volatile anesthetics on emergence agitation in adults remains unclear. We compared the degree of emergence agitation between desflurane and sevoflurane anesthesia in adults undergoing thyroid surgery. Findings One hundred and sixteen patients with American Society of Anesthesiologists status 1 or 2 were randomized into two groups: the desflurane group (group D) and the sevoflurane group (group S). After induction of anesthesia with fentanyl (1–2 μg/kg) and propofol (1.5–2.5 mg/kg), tracheal intubation was facilitated with suxamethonium (0.5–1.0 mg/kg). In group D, anesthesia was maintained with desflurane in 66% nitrous oxide and 33% oxygen supplemented with fentanyl when necessary; in group S, sevoflurane was used instead of desflurane. After the end of the surgery, emergence agitation was evaluated with a modified pediatric anesthesia emergence delirium scale (ranging from 0 to 16, with higher scores indicating more severe emergence agitation) before extubation. Time to extubation from the end of the surgery, postoperative pain (evaluated by a numerical rating scale [NRS]), and postoperative nausea and vomiting (PONV) after surgery were examined. The degree of emergence agitation was more severe in group D than in group S (median [interquartile range]: 5 [4–7] vs 4 [2–6], p = 0.008). Time to extubation, NRS scores, and PONV rates were similar between the two groups. Conclusions Desflurane anesthesia worsened emergence agitation as compared with sevoflurane in adult patients undergoing thyroid surgery, but did not affect time to extubation, postoperative pain, or PONV. Trial registration UMIN000014215http://link.springer.com/article/10.1186/s40981-017-0106-5Emergence agitationVolatile anestheticsAdult patientsThyroid surgery |
| spellingShingle | Takeshi Suzuki Takuya Kurazumi Tomomi Ueda Hiromasa Nagata Takashige Yamada Shizuko Kosugi Saori Hashiguchi Koichi Ito Hiroshi Morisaki Desflurane anesthesia worsens emergence agitation in adult patients undergoing thyroid surgery compared to sevoflurane anesthesia JA Clinical Reports Emergence agitation Volatile anesthetics Adult patients Thyroid surgery |
| title | Desflurane anesthesia worsens emergence agitation in adult patients undergoing thyroid surgery compared to sevoflurane anesthesia |
| title_full | Desflurane anesthesia worsens emergence agitation in adult patients undergoing thyroid surgery compared to sevoflurane anesthesia |
| title_fullStr | Desflurane anesthesia worsens emergence agitation in adult patients undergoing thyroid surgery compared to sevoflurane anesthesia |
| title_full_unstemmed | Desflurane anesthesia worsens emergence agitation in adult patients undergoing thyroid surgery compared to sevoflurane anesthesia |
| title_short | Desflurane anesthesia worsens emergence agitation in adult patients undergoing thyroid surgery compared to sevoflurane anesthesia |
| title_sort | desflurane anesthesia worsens emergence agitation in adult patients undergoing thyroid surgery compared to sevoflurane anesthesia |
| topic | Emergence agitation Volatile anesthetics Adult patients Thyroid surgery |
| url | http://link.springer.com/article/10.1186/s40981-017-0106-5 |
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