Living donor liver transplantation for idiopathic portal hypertension with focal nodular hyperplasia
Abstract The patient was a 61-year-old woman with a history of diabetes mellitus who had undergone ileocecal resection for ascending colon carcinoma 5 years earlier, followed by a postoperative adjuvant chemotherapy with XELOX (capecitabine + oxaliplatin). During follow-up, the liver gradually atrop...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-04-01
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| Series: | Surgical Case Reports |
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| Online Access: | https://doi.org/10.1186/s40792-022-01428-3 |
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| author | Yoshiaki Tanji Kenei Furukawa Yosuke Igarashi Mitsuru Yanagaki Koichiro Haruki Yoshihiro Shirai Tomohiko Taniai Takeshi Gocho Norimitsu Okui Toru Ikegami |
| author_facet | Yoshiaki Tanji Kenei Furukawa Yosuke Igarashi Mitsuru Yanagaki Koichiro Haruki Yoshihiro Shirai Tomohiko Taniai Takeshi Gocho Norimitsu Okui Toru Ikegami |
| author_sort | Yoshiaki Tanji |
| collection | DOAJ |
| description | Abstract The patient was a 61-year-old woman with a history of diabetes mellitus who had undergone ileocecal resection for ascending colon carcinoma 5 years earlier, followed by a postoperative adjuvant chemotherapy with XELOX (capecitabine + oxaliplatin). During follow-up, the liver gradually atrophied, and radiological imaging showed suspicious findings of 20 × 14 mm hepatocellular carcinoma (HCC) in the right lobe of the liver. The patient also underwent endoscopic variceal ligation for the esophageal varices. She was referred to our hospital for living donor liver transplantation (LDLT) due to decompensated liver cirrhosis with HCC. The patient did not have hepatitis B or C, and history of alcohol, suggesting that her liver cirrhosis was caused by a non-alcoholic steatohepatitis. The Child–Pugh score was 10 points (class C) and the Model for End-Stage Liver Disease (MELD) score was 8 points. The possibility of HCC could not be ruled out, and LDLT was performed. Postoperative pathological examination revealed idiopathic portal hypertension (IPH), and the mass lesion was diagnosed as focal nodular hyperplasia (FNH). The postoperative course was uneventful and the patient was discharged on postoperative day 14. This is the first case of liver transplantation for IPH with FNH. |
| first_indexed | 2024-12-12T23:25:22Z |
| format | Article |
| id | doaj.art-90d58aca2fa243bbbf6eeb2ca85a38b8 |
| institution | Directory Open Access Journal |
| issn | 2198-7793 |
| language | English |
| last_indexed | 2024-12-12T23:25:22Z |
| publishDate | 2022-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj.art-90d58aca2fa243bbbf6eeb2ca85a38b82022-12-22T00:08:07ZengSpringerOpenSurgical Case Reports2198-77932022-04-01811610.1186/s40792-022-01428-3Living donor liver transplantation for idiopathic portal hypertension with focal nodular hyperplasiaYoshiaki Tanji0Kenei Furukawa1Yosuke Igarashi2Mitsuru Yanagaki3Koichiro Haruki4Yoshihiro Shirai5Tomohiko Taniai6Takeshi Gocho7Norimitsu Okui8Toru Ikegami9Division of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of MedicineDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of MedicineDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of MedicineDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of MedicineDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of MedicineDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of MedicineDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of MedicineDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of MedicineDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of MedicineDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of MedicineAbstract The patient was a 61-year-old woman with a history of diabetes mellitus who had undergone ileocecal resection for ascending colon carcinoma 5 years earlier, followed by a postoperative adjuvant chemotherapy with XELOX (capecitabine + oxaliplatin). During follow-up, the liver gradually atrophied, and radiological imaging showed suspicious findings of 20 × 14 mm hepatocellular carcinoma (HCC) in the right lobe of the liver. The patient also underwent endoscopic variceal ligation for the esophageal varices. She was referred to our hospital for living donor liver transplantation (LDLT) due to decompensated liver cirrhosis with HCC. The patient did not have hepatitis B or C, and history of alcohol, suggesting that her liver cirrhosis was caused by a non-alcoholic steatohepatitis. The Child–Pugh score was 10 points (class C) and the Model for End-Stage Liver Disease (MELD) score was 8 points. The possibility of HCC could not be ruled out, and LDLT was performed. Postoperative pathological examination revealed idiopathic portal hypertension (IPH), and the mass lesion was diagnosed as focal nodular hyperplasia (FNH). The postoperative course was uneventful and the patient was discharged on postoperative day 14. This is the first case of liver transplantation for IPH with FNH.https://doi.org/10.1186/s40792-022-01428-3Living donor liver transplantationIdiopathic portal hypertensionFocal nodular hyperplasiaHepatocellular carcinoma |
| spellingShingle | Yoshiaki Tanji Kenei Furukawa Yosuke Igarashi Mitsuru Yanagaki Koichiro Haruki Yoshihiro Shirai Tomohiko Taniai Takeshi Gocho Norimitsu Okui Toru Ikegami Living donor liver transplantation for idiopathic portal hypertension with focal nodular hyperplasia Surgical Case Reports Living donor liver transplantation Idiopathic portal hypertension Focal nodular hyperplasia Hepatocellular carcinoma |
| title | Living donor liver transplantation for idiopathic portal hypertension with focal nodular hyperplasia |
| title_full | Living donor liver transplantation for idiopathic portal hypertension with focal nodular hyperplasia |
| title_fullStr | Living donor liver transplantation for idiopathic portal hypertension with focal nodular hyperplasia |
| title_full_unstemmed | Living donor liver transplantation for idiopathic portal hypertension with focal nodular hyperplasia |
| title_short | Living donor liver transplantation for idiopathic portal hypertension with focal nodular hyperplasia |
| title_sort | living donor liver transplantation for idiopathic portal hypertension with focal nodular hyperplasia |
| topic | Living donor liver transplantation Idiopathic portal hypertension Focal nodular hyperplasia Hepatocellular carcinoma |
| url | https://doi.org/10.1186/s40792-022-01428-3 |
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