Methods for Molecular Nanoanalysis
This contribution reviews methods based on scanning probe microscopy for molecular analysis and identification on a length scale of 20–200 nm. Aperture scanning near-field optical microscopy (SNOM) was initially developed in our group for chemical analysis and imaging using fluorescence an...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2006-11-01
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| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://chimia.ch/chimia/article/view/4247 |
| _version_ | 1798014555839791104 |
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| author | Thomas Schmid Thomas A. Schmitz Patrick D. Setz Boon-Siang Yeo Weihua Zhang Renato Zenobi |
| author_facet | Thomas Schmid Thomas A. Schmitz Patrick D. Setz Boon-Siang Yeo Weihua Zhang Renato Zenobi |
| author_sort | Thomas Schmid |
| collection | DOAJ |
| description |
This contribution reviews methods based on scanning probe microscopy for molecular analysis and identification on a length scale of 20–200 nm. Aperture scanning near-field optical microscopy (SNOM) was initially developed in our group for chemical analysis and imaging using fluorescence
and Raman spectroscopies, with a resolution beyond the optical diffraction limit. In recent years, tip-enhanced Raman spectroscopy was developed into an analytical tool capable of a spatial resolution less than 50 nm and, using the 'gap' mode of operation, the promise for single molecule sensitivity
and even higher spatial resolution. Aperture SNOM with pulsed laser irradiation can be used for nanoscale laser ablation. With an interface to a very sensitive mass spectrometer, this provides a platform for nanoscale mass spectrometry using atmospheric pressure sampling. The preparation of
fiber tips for aperture SNOM as well as metallized a FM tips and etched metal wires for aperture less SNOM applications is reviewed. Finally, applications for the chemical analysis of thin molecular films and of biological samples are presented.
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| first_indexed | 2024-04-11T15:20:28Z |
| format | Article |
| id | doaj.art-90d704cf89f14efe967a49deee198193 |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-04-11T15:20:28Z |
| publishDate | 2006-11-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-90d704cf89f14efe967a49deee1981932022-12-22T04:16:23ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242006-11-01601110.2533/chimia.2006.783Methods for Molecular NanoanalysisThomas SchmidThomas A. SchmitzPatrick D. SetzBoon-Siang YeoWeihua ZhangRenato Zenobi This contribution reviews methods based on scanning probe microscopy for molecular analysis and identification on a length scale of 20–200 nm. Aperture scanning near-field optical microscopy (SNOM) was initially developed in our group for chemical analysis and imaging using fluorescence and Raman spectroscopies, with a resolution beyond the optical diffraction limit. In recent years, tip-enhanced Raman spectroscopy was developed into an analytical tool capable of a spatial resolution less than 50 nm and, using the 'gap' mode of operation, the promise for single molecule sensitivity and even higher spatial resolution. Aperture SNOM with pulsed laser irradiation can be used for nanoscale laser ablation. With an interface to a very sensitive mass spectrometer, this provides a platform for nanoscale mass spectrometry using atmospheric pressure sampling. The preparation of fiber tips for aperture SNOM as well as metallized a FM tips and etched metal wires for aperture less SNOM applications is reviewed. Finally, applications for the chemical analysis of thin molecular films and of biological samples are presented. https://chimia.ch/chimia/article/view/4247Atmospheric pressure nanoscale laser ablation mass spectrometryScanning near-field optical microscopy (snom)Tip-enhanced raman scattering (ters) |
| spellingShingle | Thomas Schmid Thomas A. Schmitz Patrick D. Setz Boon-Siang Yeo Weihua Zhang Renato Zenobi Methods for Molecular Nanoanalysis CHIMIA Atmospheric pressure nanoscale laser ablation mass spectrometry Scanning near-field optical microscopy (snom) Tip-enhanced raman scattering (ters) |
| title | Methods for Molecular Nanoanalysis |
| title_full | Methods for Molecular Nanoanalysis |
| title_fullStr | Methods for Molecular Nanoanalysis |
| title_full_unstemmed | Methods for Molecular Nanoanalysis |
| title_short | Methods for Molecular Nanoanalysis |
| title_sort | methods for molecular nanoanalysis |
| topic | Atmospheric pressure nanoscale laser ablation mass spectrometry Scanning near-field optical microscopy (snom) Tip-enhanced raman scattering (ters) |
| url | https://chimia.ch/chimia/article/view/4247 |
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