The Design of Rapid Self-Healing Alginate Hydrogel with Dendritic Crosslinking Network
Self-healing alginate hydrogels play important roles in the biological field due to their biocompatibility and ability to recover after cracking. One of the primary targets for researchers in this field is to increase the self-healing speed. Sodium alginate was oxidized, generating aldehyde groups o...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/21/7367 |
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| author | Dingxuan Wang Yuhan Li Haobo Zhang Zhaorong Ren Kefan Fan Jue Cheng Junying Zhang Feng Gao |
| author_facet | Dingxuan Wang Yuhan Li Haobo Zhang Zhaorong Ren Kefan Fan Jue Cheng Junying Zhang Feng Gao |
| author_sort | Dingxuan Wang |
| collection | DOAJ |
| description | Self-healing alginate hydrogels play important roles in the biological field due to their biocompatibility and ability to recover after cracking. One of the primary targets for researchers in this field is to increase the self-healing speed. Sodium alginate was oxidized, generating aldehyde groups on the chains, which were then crosslinked by poly(amino) amine (PAMAM) via Schiff base reaction. The dendritic structure was introduced to the alginate hydrogel in this work, which was supposed to promote intermolecular interactions and accelerate the self-healing process. Results showed that the hydrogel (ADA-PAMAM) formed a gel within 2.5 min with stable rheological properties. Within 25 min, the hydrogel recovered under room temperature. Furthermore, the aldehyde degree of alginate dialdehyde with a different oxidation degree was characterized through gel permeation chromatograph aligned with multi-angle laser light scattering and ultraviolet (UV) absorption. The chemical structure of the hydrogel was characterized through Fourier transform infrared spectroscopy and UV-vis spectra. The SEM and laser scanning confocal microscope (CLSM) presented the antibiotic ability of ADA-PAMAM against both <i>S. aureus</i> and <i>E. coli</i> when incubated with 10<sup>−7</sup> CFU microorganism under room temperature for 2 h. This work presented a strategy to promote the self-healing of hydrogel through forming a dendritic dynamic crosslinking network. |
| first_indexed | 2024-03-09T18:48:07Z |
| format | Article |
| id | doaj.art-90d781b9a0be444d8fb05de14451a68c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T18:48:07Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-90d781b9a0be444d8fb05de14451a68c2023-11-24T06:03:04ZengMDPI AGMolecules1420-30492022-10-012721736710.3390/molecules27217367The Design of Rapid Self-Healing Alginate Hydrogel with Dendritic Crosslinking NetworkDingxuan Wang0Yuhan Li1Haobo Zhang2Zhaorong Ren3Kefan Fan4Jue Cheng5Junying Zhang6Feng Gao7School of Material Science and Engineering, Beijing University of Chemistry Technology, Beijing 100029, ChinaSchool of Material Science and Engineering, Beijing University of Chemistry Technology, Beijing 100029, ChinaSchool of Material Science and Engineering, Beijing University of Chemistry Technology, Beijing 100029, ChinaSchool of Material Science and Engineering, Beijing University of Chemistry Technology, Beijing 100029, ChinaSchool of Material Science and Engineering, Beijing University of Chemistry Technology, Beijing 100029, ChinaSchool of Material Science and Engineering, Beijing University of Chemistry Technology, Beijing 100029, ChinaSchool of Material Science and Engineering, Beijing University of Chemistry Technology, Beijing 100029, ChinaSchool of Material Science and Engineering, Beijing University of Chemistry Technology, Beijing 100029, ChinaSelf-healing alginate hydrogels play important roles in the biological field due to their biocompatibility and ability to recover after cracking. One of the primary targets for researchers in this field is to increase the self-healing speed. Sodium alginate was oxidized, generating aldehyde groups on the chains, which were then crosslinked by poly(amino) amine (PAMAM) via Schiff base reaction. The dendritic structure was introduced to the alginate hydrogel in this work, which was supposed to promote intermolecular interactions and accelerate the self-healing process. Results showed that the hydrogel (ADA-PAMAM) formed a gel within 2.5 min with stable rheological properties. Within 25 min, the hydrogel recovered under room temperature. Furthermore, the aldehyde degree of alginate dialdehyde with a different oxidation degree was characterized through gel permeation chromatograph aligned with multi-angle laser light scattering and ultraviolet (UV) absorption. The chemical structure of the hydrogel was characterized through Fourier transform infrared spectroscopy and UV-vis spectra. The SEM and laser scanning confocal microscope (CLSM) presented the antibiotic ability of ADA-PAMAM against both <i>S. aureus</i> and <i>E. coli</i> when incubated with 10<sup>−7</sup> CFU microorganism under room temperature for 2 h. This work presented a strategy to promote the self-healing of hydrogel through forming a dendritic dynamic crosslinking network.https://www.mdpi.com/1420-3049/27/21/7367alginate hydrogelPAMAMdendritic crosslinking networkrapid self-healing |
| spellingShingle | Dingxuan Wang Yuhan Li Haobo Zhang Zhaorong Ren Kefan Fan Jue Cheng Junying Zhang Feng Gao The Design of Rapid Self-Healing Alginate Hydrogel with Dendritic Crosslinking Network Molecules alginate hydrogel PAMAM dendritic crosslinking network rapid self-healing |
| title | The Design of Rapid Self-Healing Alginate Hydrogel with Dendritic Crosslinking Network |
| title_full | The Design of Rapid Self-Healing Alginate Hydrogel with Dendritic Crosslinking Network |
| title_fullStr | The Design of Rapid Self-Healing Alginate Hydrogel with Dendritic Crosslinking Network |
| title_full_unstemmed | The Design of Rapid Self-Healing Alginate Hydrogel with Dendritic Crosslinking Network |
| title_short | The Design of Rapid Self-Healing Alginate Hydrogel with Dendritic Crosslinking Network |
| title_sort | design of rapid self healing alginate hydrogel with dendritic crosslinking network |
| topic | alginate hydrogel PAMAM dendritic crosslinking network rapid self-healing |
| url | https://www.mdpi.com/1420-3049/27/21/7367 |
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