Pea protein hydrolysate reduces blood glucose in high-fat diet and streptozotocin-induced diabetic mice
IntroductionFood proteins have been recognized as an ideal source to release bioactive peptides with the potential to intervene nutrition related chronic diseases, such as cardiovascular diseases, obesity and diabetes. Our previous studies showed that pea protein hydrolysate (PPH) could suppress hep...
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1298046/full |
| _version_ | 1827587750584385536 |
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| author | Wang Liao Xinyi Cao Hui Xia Shaokang Wang Liang Chen Guiju Sun |
| author_facet | Wang Liao Xinyi Cao Hui Xia Shaokang Wang Liang Chen Guiju Sun |
| author_sort | Wang Liao |
| collection | DOAJ |
| description | IntroductionFood proteins have been recognized as an ideal source to release bioactive peptides with the potential to intervene nutrition related chronic diseases, such as cardiovascular diseases, obesity and diabetes. Our previous studies showed that pea protein hydrolysate (PPH) could suppress hepatic glucose production in hepatic cells via inhibiting the gluconeogenic signaling. Thus, we hypothesized that PPH could play the hypoglycemic role in vivo.MethodsIn the present study, the mice model with type 2 diabetic mellitus (T2DM) was developed by high-fat diet and low dose of streptozotocin injections. PPH was administered orally with a dosage of 1000 mg/kg body weight for 9 weeks, followed by the downstream biomedical analyses.ResultsThe results showed that the 9-week treatment of PPH could reduce fasting blood glucose by 29.6% and improve glucose tolerance in the T2DM mice. The associated mechanisms included suppression of the gluconeogenic pathway, activation of the insulin signaling and modulation of the renin angiotensin system in the liver of the diabetic mice. In addition, the levels of pro-inflammatory markers in both liver and serum were reduced by the PPH treatment.ConclusionThe hypoglycemic effect of PPH in T2DM mice was demonstrated in the present study. Findings from this study could provide rationale to incorporate PPH into functional foods or nutraceuticals for glycemic control. |
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| format | Article |
| id | doaj.art-90d86c34029a4b11a1e2df81a7d438fe |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-09T00:23:28Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-90d86c34029a4b11a1e2df81a7d438fe2023-12-12T05:21:54ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-12-011010.3389/fnut.2023.12980461298046Pea protein hydrolysate reduces blood glucose in high-fat diet and streptozotocin-induced diabetic miceWang Liao0Xinyi Cao1Hui Xia2Shaokang Wang3Liang Chen4Guiju Sun5Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, ChinaPublic Service Platform of South China Sea for R&D Marine Biomedicine Resources, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, ChinaIntroductionFood proteins have been recognized as an ideal source to release bioactive peptides with the potential to intervene nutrition related chronic diseases, such as cardiovascular diseases, obesity and diabetes. Our previous studies showed that pea protein hydrolysate (PPH) could suppress hepatic glucose production in hepatic cells via inhibiting the gluconeogenic signaling. Thus, we hypothesized that PPH could play the hypoglycemic role in vivo.MethodsIn the present study, the mice model with type 2 diabetic mellitus (T2DM) was developed by high-fat diet and low dose of streptozotocin injections. PPH was administered orally with a dosage of 1000 mg/kg body weight for 9 weeks, followed by the downstream biomedical analyses.ResultsThe results showed that the 9-week treatment of PPH could reduce fasting blood glucose by 29.6% and improve glucose tolerance in the T2DM mice. The associated mechanisms included suppression of the gluconeogenic pathway, activation of the insulin signaling and modulation of the renin angiotensin system in the liver of the diabetic mice. In addition, the levels of pro-inflammatory markers in both liver and serum were reduced by the PPH treatment.ConclusionThe hypoglycemic effect of PPH in T2DM mice was demonstrated in the present study. Findings from this study could provide rationale to incorporate PPH into functional foods or nutraceuticals for glycemic control.https://www.frontiersin.org/articles/10.3389/fnut.2023.1298046/fullpea protein hydrolysatetype 2 diabetesgluconeogenesisinsulin sensitivitychronic disease |
| spellingShingle | Wang Liao Xinyi Cao Hui Xia Shaokang Wang Liang Chen Guiju Sun Pea protein hydrolysate reduces blood glucose in high-fat diet and streptozotocin-induced diabetic mice Frontiers in Nutrition pea protein hydrolysate type 2 diabetes gluconeogenesis insulin sensitivity chronic disease |
| title | Pea protein hydrolysate reduces blood glucose in high-fat diet and streptozotocin-induced diabetic mice |
| title_full | Pea protein hydrolysate reduces blood glucose in high-fat diet and streptozotocin-induced diabetic mice |
| title_fullStr | Pea protein hydrolysate reduces blood glucose in high-fat diet and streptozotocin-induced diabetic mice |
| title_full_unstemmed | Pea protein hydrolysate reduces blood glucose in high-fat diet and streptozotocin-induced diabetic mice |
| title_short | Pea protein hydrolysate reduces blood glucose in high-fat diet and streptozotocin-induced diabetic mice |
| title_sort | pea protein hydrolysate reduces blood glucose in high fat diet and streptozotocin induced diabetic mice |
| topic | pea protein hydrolysate type 2 diabetes gluconeogenesis insulin sensitivity chronic disease |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1298046/full |
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