Dietary Polyphenols as Therapeutic Intervention for Alzheimer’s Disease: A Mechanistic Insight
Dietary polyphenols encompass a diverse range of secondary metabolites found in nature, such as fruits, vegetables, herbal teas, wine, and cocoa products, etc. Structurally, they are either derivatives or isomers of phenol acid, isoflavonoids and possess hidden health promoting characteristics, such...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-03-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/11/3/554 |
| _version_ | 1797473066991747072 |
|---|---|
| author | Syed Nasir Abbas Bukhari |
| author_facet | Syed Nasir Abbas Bukhari |
| author_sort | Syed Nasir Abbas Bukhari |
| collection | DOAJ |
| description | Dietary polyphenols encompass a diverse range of secondary metabolites found in nature, such as fruits, vegetables, herbal teas, wine, and cocoa products, etc. Structurally, they are either derivatives or isomers of phenol acid, isoflavonoids and possess hidden health promoting characteristics, such as antioxidative, anti-aging, anti-cancerous and many more. The use of such polyphenols in combating the neuropathological war raging in this generation is currently a hotly debated topic. Lately, Alzheimer’s disease (AD) is emerging as the most common neuropathological disease, destroying the livelihoods of millions in one way or another. Any therapeutic intervention to curtail its advancement in the generation to come has been in vain to date. Using dietary polyphenols to construct the barricade around it is going to be an effective strategy, taking into account their hidden potential to counter multifactorial events taking place under such pathology. Besides their strong antioxidant properties, naturally occurring polyphenols are reported to have neuroprotective effects by modulating the Aβ biogenesis pathway in Alzheimer’s disease. Thus, in this review, I am focusing on unlocking the hidden secrets of dietary polyphenols and their mechanistic advantages to fight the war with AD and related pathology. |
| first_indexed | 2024-03-09T20:10:50Z |
| format | Article |
| id | doaj.art-90dafe68828c4d6a82072cba52a57385 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T20:10:50Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-90dafe68828c4d6a82072cba52a573852023-11-24T00:18:42ZengMDPI AGAntioxidants2076-39212022-03-0111355410.3390/antiox11030554Dietary Polyphenols as Therapeutic Intervention for Alzheimer’s Disease: A Mechanistic InsightSyed Nasir Abbas Bukhari0Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Aljouf 2014, Saudi ArabiaDietary polyphenols encompass a diverse range of secondary metabolites found in nature, such as fruits, vegetables, herbal teas, wine, and cocoa products, etc. Structurally, they are either derivatives or isomers of phenol acid, isoflavonoids and possess hidden health promoting characteristics, such as antioxidative, anti-aging, anti-cancerous and many more. The use of such polyphenols in combating the neuropathological war raging in this generation is currently a hotly debated topic. Lately, Alzheimer’s disease (AD) is emerging as the most common neuropathological disease, destroying the livelihoods of millions in one way or another. Any therapeutic intervention to curtail its advancement in the generation to come has been in vain to date. Using dietary polyphenols to construct the barricade around it is going to be an effective strategy, taking into account their hidden potential to counter multifactorial events taking place under such pathology. Besides their strong antioxidant properties, naturally occurring polyphenols are reported to have neuroprotective effects by modulating the Aβ biogenesis pathway in Alzheimer’s disease. Thus, in this review, I am focusing on unlocking the hidden secrets of dietary polyphenols and their mechanistic advantages to fight the war with AD and related pathology.https://www.mdpi.com/2076-3921/11/3/554amyloidlike curcuminquercetinhomeostasismetal chelation |
| spellingShingle | Syed Nasir Abbas Bukhari Dietary Polyphenols as Therapeutic Intervention for Alzheimer’s Disease: A Mechanistic Insight Antioxidants amyloid like curcumin quercetin homeostasis metal chelation |
| title | Dietary Polyphenols as Therapeutic Intervention for Alzheimer’s Disease: A Mechanistic Insight |
| title_full | Dietary Polyphenols as Therapeutic Intervention for Alzheimer’s Disease: A Mechanistic Insight |
| title_fullStr | Dietary Polyphenols as Therapeutic Intervention for Alzheimer’s Disease: A Mechanistic Insight |
| title_full_unstemmed | Dietary Polyphenols as Therapeutic Intervention for Alzheimer’s Disease: A Mechanistic Insight |
| title_short | Dietary Polyphenols as Therapeutic Intervention for Alzheimer’s Disease: A Mechanistic Insight |
| title_sort | dietary polyphenols as therapeutic intervention for alzheimer s disease a mechanistic insight |
| topic | amyloid like curcumin quercetin homeostasis metal chelation |
| url | https://www.mdpi.com/2076-3921/11/3/554 |
| work_keys_str_mv | AT syednasirabbasbukhari dietarypolyphenolsastherapeuticinterventionforalzheimersdiseaseamechanisticinsight |