Osteoprotegerin, sclerostin, and osteocalcin serum levels in thyroid disorder patients
The maintenance of thyroid hormone homeostasis is essential in the regulation of skeletal system development, bone tissue mineralization and fracture risk prevention. This study was carried out to evaluate the serum level of osteoprotegerin (OPG), sclerostin (SOST), and osteocalcin (OC) in hypo- and...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2021-10-01
|
| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2021/10/Rija_5_21.pdf |
| _version_ | 1797422314805002240 |
|---|---|
| author | F. F. Rija S. Z. Hussein M. A. Abdalla |
| author_facet | F. F. Rija S. Z. Hussein M. A. Abdalla |
| author_sort | F. F. Rija |
| collection | DOAJ |
| description | The maintenance of thyroid hormone homeostasis is essential in the regulation of skeletal system development, bone tissue mineralization and fracture risk prevention. This study was carried out to evaluate the serum level of osteoprotegerin (OPG), sclerostin (SOST), and osteocalcin (OC) in hypo- and hyperthyroidism patients. A total number of examined patients was 90 individuals, 30 of them were normal as a control group, the rest 60 individuals were arranged in two groups: 30 patients with hypothyroidism and 30 patients with hyperthyroidism. Serum assay tests for OPG, SOST, OC, thyroid stimulating hormone (TSH), total triiodothyronine (T3), and total thyroxine (T4) were used. The present study reported high levels of SOST, T3, and T4 and low levels of OPG, OC, and TSH in patients with hyperthyroidism compared to control. Whereas in patients with hypothyroidism only SOST and TSH levels were increased, but OPG, OC, T3, and T4 levels were low compared to control. The data obtained indicate the correlation on osteoprotegerin, sclerostin, and osteocalcin levels with thyroid hormones disturbances. |
| first_indexed | 2024-03-09T07:30:25Z |
| format | Article |
| id | doaj.art-90db68470eb74069bfaddbb396a37e94 |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-09T07:30:25Z |
| publishDate | 2021-10-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-90db68470eb74069bfaddbb396a37e942023-12-03T06:27:14ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032021-10-0193511712110.15407/ubj93.05.117Osteoprotegerin, sclerostin, and osteocalcin serum levels in thyroid disorder patientsF. F. Rija0https://orcid.org/0000-0002-6325-5241S. Z. Hussein1https://orcid.org/0000-0003-3643-5834M. A. Abdalla2https://orcid.org/0000-0001-8122-3692Department of Biology, Tikrit University – College of Sciences, Tikrit, IraqClinical Biochemistry Unit, Salah Aldeen Health Directorate, Tikrit, IraqDepartment of Human Anatomy, Tikrit University College of Medicine, Tikrit, IraqThe maintenance of thyroid hormone homeostasis is essential in the regulation of skeletal system development, bone tissue mineralization and fracture risk prevention. This study was carried out to evaluate the serum level of osteoprotegerin (OPG), sclerostin (SOST), and osteocalcin (OC) in hypo- and hyperthyroidism patients. A total number of examined patients was 90 individuals, 30 of them were normal as a control group, the rest 60 individuals were arranged in two groups: 30 patients with hypothyroidism and 30 patients with hyperthyroidism. Serum assay tests for OPG, SOST, OC, thyroid stimulating hormone (TSH), total triiodothyronine (T3), and total thyroxine (T4) were used. The present study reported high levels of SOST, T3, and T4 and low levels of OPG, OC, and TSH in patients with hyperthyroidism compared to control. Whereas in patients with hypothyroidism only SOST and TSH levels were increased, but OPG, OC, T3, and T4 levels were low compared to control. The data obtained indicate the correlation on osteoprotegerin, sclerostin, and osteocalcin levels with thyroid hormones disturbances.http://ukrbiochemjournal.org/wp-content/uploads/2021/10/Rija_5_21.pdfosteocalcinosteoprotegerinsclerostinthyroid disorders |
| spellingShingle | F. F. Rija S. Z. Hussein M. A. Abdalla Osteoprotegerin, sclerostin, and osteocalcin serum levels in thyroid disorder patients The Ukrainian Biochemical Journal osteocalcin osteoprotegerin sclerostin thyroid disorders |
| title | Osteoprotegerin, sclerostin, and osteocalcin serum levels in thyroid disorder patients |
| title_full | Osteoprotegerin, sclerostin, and osteocalcin serum levels in thyroid disorder patients |
| title_fullStr | Osteoprotegerin, sclerostin, and osteocalcin serum levels in thyroid disorder patients |
| title_full_unstemmed | Osteoprotegerin, sclerostin, and osteocalcin serum levels in thyroid disorder patients |
| title_short | Osteoprotegerin, sclerostin, and osteocalcin serum levels in thyroid disorder patients |
| title_sort | osteoprotegerin sclerostin and osteocalcin serum levels in thyroid disorder patients |
| topic | osteocalcin osteoprotegerin sclerostin thyroid disorders |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2021/10/Rija_5_21.pdf |
| work_keys_str_mv | AT ffrija osteoprotegerinsclerostinandosteocalcinserumlevelsinthyroiddisorderpatients AT szhussein osteoprotegerinsclerostinandosteocalcinserumlevelsinthyroiddisorderpatients AT maabdalla osteoprotegerinsclerostinandosteocalcinserumlevelsinthyroiddisorderpatients |