Genomic Insights and Synthetic Biology Applications of Marine Actinomycete <i>Streptomyces griseoincarnatus</i> HNS054
The marine bacterium <i>Streptomyces</i> sp. HNS054 shows promise as a platform for producing natural products. Isolated from a marine sponge, HNS054 possesses several desirable traits for bioengineering: rapid growth, salt tolerance, and compatibility with genetic tools. Its genome cont...
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| Format: | Article |
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MDPI AG
2024-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/6/3127 |
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| author | Qinghua Wang Jing Zhao Zhaoyuan Liu Shaoxiong Ding Zhiyong Huang Jun Chen |
| author_facet | Qinghua Wang Jing Zhao Zhaoyuan Liu Shaoxiong Ding Zhiyong Huang Jun Chen |
| author_sort | Qinghua Wang |
| collection | DOAJ |
| description | The marine bacterium <i>Streptomyces</i> sp. HNS054 shows promise as a platform for producing natural products. Isolated from a marine sponge, HNS054 possesses several desirable traits for bioengineering: rapid growth, salt tolerance, and compatibility with genetic tools. Its genome contains 21 potential biosynthetic gene clusters, offering a rich source of natural products. We successfully engineered HNS054 to increase the production of aborycin and actinorhodin by 4.5-fold and 1.2-fold, respectively, compared to <i>S. coelicolor</i> M1346 counterparts. With its unique features and amenability to genetic manipulation, HNS054 emerges as a promising candidate for developing novel marine-derived drugs and other valuable compounds. |
| first_indexed | 2024-04-24T18:12:34Z |
| format | Article |
| id | doaj.art-90de26fdc1c2496d84881d5cdd356150 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-24T18:12:34Z |
| publishDate | 2024-03-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-90de26fdc1c2496d84881d5cdd3561502024-03-27T13:45:06ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-03-01256312710.3390/ijms25063127Genomic Insights and Synthetic Biology Applications of Marine Actinomycete <i>Streptomyces griseoincarnatus</i> HNS054Qinghua Wang0Jing Zhao1Zhaoyuan Liu2Shaoxiong Ding3Zhiyong Huang4Jun Chen5State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361102, ChinaTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, ChinaState Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361102, ChinaThe marine bacterium <i>Streptomyces</i> sp. HNS054 shows promise as a platform for producing natural products. Isolated from a marine sponge, HNS054 possesses several desirable traits for bioengineering: rapid growth, salt tolerance, and compatibility with genetic tools. Its genome contains 21 potential biosynthetic gene clusters, offering a rich source of natural products. We successfully engineered HNS054 to increase the production of aborycin and actinorhodin by 4.5-fold and 1.2-fold, respectively, compared to <i>S. coelicolor</i> M1346 counterparts. With its unique features and amenability to genetic manipulation, HNS054 emerges as a promising candidate for developing novel marine-derived drugs and other valuable compounds.https://www.mdpi.com/1422-0067/25/6/3127marine actinomycetechassisnatural productbiosynthetic gene clusterrapid growthMSGE |
| spellingShingle | Qinghua Wang Jing Zhao Zhaoyuan Liu Shaoxiong Ding Zhiyong Huang Jun Chen Genomic Insights and Synthetic Biology Applications of Marine Actinomycete <i>Streptomyces griseoincarnatus</i> HNS054 International Journal of Molecular Sciences marine actinomycete chassis natural product biosynthetic gene cluster rapid growth MSGE |
| title | Genomic Insights and Synthetic Biology Applications of Marine Actinomycete <i>Streptomyces griseoincarnatus</i> HNS054 |
| title_full | Genomic Insights and Synthetic Biology Applications of Marine Actinomycete <i>Streptomyces griseoincarnatus</i> HNS054 |
| title_fullStr | Genomic Insights and Synthetic Biology Applications of Marine Actinomycete <i>Streptomyces griseoincarnatus</i> HNS054 |
| title_full_unstemmed | Genomic Insights and Synthetic Biology Applications of Marine Actinomycete <i>Streptomyces griseoincarnatus</i> HNS054 |
| title_short | Genomic Insights and Synthetic Biology Applications of Marine Actinomycete <i>Streptomyces griseoincarnatus</i> HNS054 |
| title_sort | genomic insights and synthetic biology applications of marine actinomycete i streptomyces griseoincarnatus i hns054 |
| topic | marine actinomycete chassis natural product biosynthetic gene cluster rapid growth MSGE |
| url | https://www.mdpi.com/1422-0067/25/6/3127 |
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