The Role of Exosomal Non-Coding RNAs in Colorectal Cancer Drug Resistance
Background: Colorectal cancer (CRC) is one of the most common types of cancer diagnosed worldwide with high morbidity; drug resistance is often responsible for treatment failure in CRC. Non-coding RNAs (ncRNAs) play distinct regulatory roles in tumorigenesis, cancer progression and chemoresistance....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/3/1473 |
| _version_ | 1797487385576996864 |
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| author | Dimitra Ioanna Lampropoulou Evangelia Pliakou Gerasimos Aravantinos Dimitrios Filippou Maria Gazouli |
| author_facet | Dimitra Ioanna Lampropoulou Evangelia Pliakou Gerasimos Aravantinos Dimitrios Filippou Maria Gazouli |
| author_sort | Dimitra Ioanna Lampropoulou |
| collection | DOAJ |
| description | Background: Colorectal cancer (CRC) is one of the most common types of cancer diagnosed worldwide with high morbidity; drug resistance is often responsible for treatment failure in CRC. Non-coding RNAs (ncRNAs) play distinct regulatory roles in tumorigenesis, cancer progression and chemoresistance. Methods: A literature search was conducted in PubMed database in order to sum up and discuss the role of exosomal ncRNAs (ex-ncRNAs) in CRC drug resistance/response and their possible mechanisms. Results: Thirty-six (36) original research articles were identified; these included exosome or extracellular vesicle (EV)-containing microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and small-interfering (siRNAs). No studies were found for piwi-interacting RNAs. Conclusions: Exosomal transfer of ncRNAs has been documented as a new mechanism of CRC drug resistance. Despite being in its infancy, it has emerged as a promising field for research in order to (i) discover novel biomarkers for therapy monitoring and/or (ii) reverse drug desensitization. |
| first_indexed | 2024-03-09T23:47:53Z |
| format | Article |
| id | doaj.art-90de4e8983354239910f6720419a74ff |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:47:53Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-90de4e8983354239910f6720419a74ff2023-11-23T16:41:06ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-01-01233147310.3390/ijms23031473The Role of Exosomal Non-Coding RNAs in Colorectal Cancer Drug ResistanceDimitra Ioanna Lampropoulou0Evangelia Pliakou1Gerasimos Aravantinos2Dimitrios Filippou3Maria Gazouli4Second Department of Medical Oncology, General Oncology Hospital of Kifissia “Agioi Anargiroi”, 14564 Athens, GreeceSecond Department of Medical Oncology, General Oncology Hospital of Kifissia “Agioi Anargiroi”, 14564 Athens, GreeceSecond Department of Medical Oncology, General Oncology Hospital of Kifissia “Agioi Anargiroi”, 14564 Athens, GreeceDepartment of Anatomy and Surgical Anatomy, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceLaboratory of Biology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceBackground: Colorectal cancer (CRC) is one of the most common types of cancer diagnosed worldwide with high morbidity; drug resistance is often responsible for treatment failure in CRC. Non-coding RNAs (ncRNAs) play distinct regulatory roles in tumorigenesis, cancer progression and chemoresistance. Methods: A literature search was conducted in PubMed database in order to sum up and discuss the role of exosomal ncRNAs (ex-ncRNAs) in CRC drug resistance/response and their possible mechanisms. Results: Thirty-six (36) original research articles were identified; these included exosome or extracellular vesicle (EV)-containing microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and small-interfering (siRNAs). No studies were found for piwi-interacting RNAs. Conclusions: Exosomal transfer of ncRNAs has been documented as a new mechanism of CRC drug resistance. Despite being in its infancy, it has emerged as a promising field for research in order to (i) discover novel biomarkers for therapy monitoring and/or (ii) reverse drug desensitization.https://www.mdpi.com/1422-0067/23/3/1473extracellular vesiclesexosomesnon-coding RNAscolorectal cancerchemoresistancedrug resistance |
| spellingShingle | Dimitra Ioanna Lampropoulou Evangelia Pliakou Gerasimos Aravantinos Dimitrios Filippou Maria Gazouli The Role of Exosomal Non-Coding RNAs in Colorectal Cancer Drug Resistance International Journal of Molecular Sciences extracellular vesicles exosomes non-coding RNAs colorectal cancer chemoresistance drug resistance |
| title | The Role of Exosomal Non-Coding RNAs in Colorectal Cancer Drug Resistance |
| title_full | The Role of Exosomal Non-Coding RNAs in Colorectal Cancer Drug Resistance |
| title_fullStr | The Role of Exosomal Non-Coding RNAs in Colorectal Cancer Drug Resistance |
| title_full_unstemmed | The Role of Exosomal Non-Coding RNAs in Colorectal Cancer Drug Resistance |
| title_short | The Role of Exosomal Non-Coding RNAs in Colorectal Cancer Drug Resistance |
| title_sort | role of exosomal non coding rnas in colorectal cancer drug resistance |
| topic | extracellular vesicles exosomes non-coding RNAs colorectal cancer chemoresistance drug resistance |
| url | https://www.mdpi.com/1422-0067/23/3/1473 |
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