Changes in energy metabolism and respiration in different tracheal narrowing in rats
Abstract Why obstructive sleep apnea (OSA) treatment does not completely restore healthy metabolic physiology is unclear. In rats, the need for respiratory homeostasis maintenance following airway obstruction (AO) is associated with a loss of thermoregulation and abnormal metabolic physiology that p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-98799-8 |
| _version_ | 1818990925375864832 |
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| author | Yael Segev Haiat Nujedat Eden Arazi Mohammad H. Assadi Ariel Tarasiuk |
| author_facet | Yael Segev Haiat Nujedat Eden Arazi Mohammad H. Assadi Ariel Tarasiuk |
| author_sort | Yael Segev |
| collection | DOAJ |
| description | Abstract Why obstructive sleep apnea (OSA) treatment does not completely restore healthy metabolic physiology is unclear. In rats, the need for respiratory homeostasis maintenance following airway obstruction (AO) is associated with a loss of thermoregulation and abnormal metabolic physiology that persists following successful obstruction removal. Here, we explored the effect of two different types of tracheal narrowing, i.e., AO and mild airway obstruction (mAO), and its removal on respiratory homeostasis and metabolic physiology. We show that after ten weeks, mAO vs. AO consumes sufficient energy that is required to maintain respiratory homeostasis and thermoregulation. Obstruction removal was associated with largely irreversible increased feeding associated with elevated serum ghrelin, hypothalamic growth hormone secretagogue receptor 1a, and a phosphorylated Akt/Akt ratio, despite normalization of breathing and energy requirements. Our study supports the need for lifestyle eating behavior management, in addition to endocrine support, in order to attain healthy metabolic physiology in OSA patients. |
| first_indexed | 2024-12-20T20:02:07Z |
| format | Article |
| id | doaj.art-90df6e12cd5b4ddeb356972aa1d03985 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T20:02:07Z |
| publishDate | 2021-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-90df6e12cd5b4ddeb356972aa1d039852022-12-21T19:28:01ZengNature PortfolioScientific Reports2045-23222021-09-011111910.1038/s41598-021-98799-8Changes in energy metabolism and respiration in different tracheal narrowing in ratsYael Segev0Haiat Nujedat1Eden Arazi2Mohammad H. Assadi3Ariel Tarasiuk4Shraga Segal Department of Microbiology, Immunology, and Genetics, Ben-Gurion University of the NegevShraga Segal Department of Microbiology, Immunology, and Genetics, Ben-Gurion University of the NegevShraga Segal Department of Microbiology, Immunology, and Genetics, Ben-Gurion University of the NegevSleep-Wake Disorders Unit, Soroka University Medical CenterSleep-Wake Disorders Unit, Soroka University Medical CenterAbstract Why obstructive sleep apnea (OSA) treatment does not completely restore healthy metabolic physiology is unclear. In rats, the need for respiratory homeostasis maintenance following airway obstruction (AO) is associated with a loss of thermoregulation and abnormal metabolic physiology that persists following successful obstruction removal. Here, we explored the effect of two different types of tracheal narrowing, i.e., AO and mild airway obstruction (mAO), and its removal on respiratory homeostasis and metabolic physiology. We show that after ten weeks, mAO vs. AO consumes sufficient energy that is required to maintain respiratory homeostasis and thermoregulation. Obstruction removal was associated with largely irreversible increased feeding associated with elevated serum ghrelin, hypothalamic growth hormone secretagogue receptor 1a, and a phosphorylated Akt/Akt ratio, despite normalization of breathing and energy requirements. Our study supports the need for lifestyle eating behavior management, in addition to endocrine support, in order to attain healthy metabolic physiology in OSA patients.https://doi.org/10.1038/s41598-021-98799-8 |
| spellingShingle | Yael Segev Haiat Nujedat Eden Arazi Mohammad H. Assadi Ariel Tarasiuk Changes in energy metabolism and respiration in different tracheal narrowing in rats Scientific Reports |
| title | Changes in energy metabolism and respiration in different tracheal narrowing in rats |
| title_full | Changes in energy metabolism and respiration in different tracheal narrowing in rats |
| title_fullStr | Changes in energy metabolism and respiration in different tracheal narrowing in rats |
| title_full_unstemmed | Changes in energy metabolism and respiration in different tracheal narrowing in rats |
| title_short | Changes in energy metabolism and respiration in different tracheal narrowing in rats |
| title_sort | changes in energy metabolism and respiration in different tracheal narrowing in rats |
| url | https://doi.org/10.1038/s41598-021-98799-8 |
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