Bmal1 knockdown in the left stellate ganglion inhibits neural activity and prevents ventricular arrhythmias after myocardial ischemia
ObjectivesThe neural activity of the left stellate ganglion (LSG) is closely related to the occurrence of ventricular arrhythmias (VAs). Bmal1 modulates genes associated with neural activity in the central nervous system. However, few studies indicated the role of Bmal1 in the LSG and the subsequent...
Main Authors: | , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2022-09-01
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Series: | Frontiers in Cardiovascular Medicine |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.937608/full |
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author | Zhongyang Yu Zhongyang Yu Zhongyang Yu Zhongyang Yu Zhongyang Yu Zhongyang Yu Zhihao Liu Zhihao Liu Zhihao Liu Zhihao Liu Zhihao Liu Zhihao Liu Liying Jiao Liying Jiao Liying Jiao Liying Jiao Liying Jiao Liying Jiao Song Zhang Song Zhang Song Zhang Song Zhang Song Zhang Song Zhang Liqing Nie Liqing Nie Liqing Nie Liqing Nie Liqing Nie Liqing Nie Yueyi Wang Yueyi Wang Yueyi Wang Yueyi Wang Yueyi Wang Yueyi Wang Liping Zhou Liping Zhou Liping Zhou Liping Zhou Liping Zhou Liping Zhou Yuhong Wang Yuhong Wang Yuhong Wang Yuhong Wang Yuhong Wang Yuhong Wang Zhihao Liu Zhihao Liu Zhihao Liu Zhihao Liu Zhihao Liu Zhihao Liu Zihan Liu Zihan Liu Zihan Liu Zihan Liu Zihan Liu Zihan Liu Xiao Xu Xiao Xu Xiao Xu Xiao Xu Xiao Xu Xiao Xu Zeyan Li Zeyan Li Zeyan Li Zeyan Li Zeyan Li Zeyan Li Yuyang Zhou Yuyang Zhou Yuyang Zhou Yuyang Zhou Yuyang Zhou Yuyang Zhou Huixin Zhou Huixin Zhou Huixin Zhou Huixin Zhou Huixin Zhou Huixin Zhou Rui Li Rui Li Rui Li Rui Li Rui Li Rui Li Chen Peng Chen Peng Chen Peng Chen Peng Chen Peng Chen Peng Lilei Yu Lilei Yu Lilei Yu Lilei Yu Lilei Yu Lilei Yu Hong Jiang Hong Jiang Hong Jiang Hong Jiang Hong Jiang Hong Jiang |
author_facet | Zhongyang Yu Zhongyang Yu Zhongyang Yu Zhongyang Yu Zhongyang Yu Zhongyang Yu Zhihao Liu Zhihao Liu Zhihao Liu Zhihao Liu Zhihao Liu Zhihao Liu Liying Jiao Liying Jiao Liying Jiao Liying Jiao Liying Jiao Liying Jiao Song Zhang Song Zhang Song Zhang Song Zhang Song Zhang Song Zhang Liqing Nie Liqing Nie Liqing Nie Liqing Nie Liqing Nie Liqing Nie Yueyi Wang Yueyi Wang Yueyi Wang Yueyi Wang Yueyi Wang Yueyi Wang Liping Zhou Liping Zhou Liping Zhou Liping Zhou Liping Zhou Liping Zhou Yuhong Wang Yuhong Wang Yuhong Wang Yuhong Wang Yuhong Wang Yuhong Wang Zhihao Liu Zhihao Liu Zhihao Liu Zhihao Liu Zhihao Liu Zhihao Liu Zihan Liu Zihan Liu Zihan Liu Zihan Liu Zihan Liu Zihan Liu Xiao Xu Xiao Xu Xiao Xu Xiao Xu Xiao Xu Xiao Xu Zeyan Li Zeyan Li Zeyan Li Zeyan Li Zeyan Li Zeyan Li Yuyang Zhou Yuyang Zhou Yuyang Zhou Yuyang Zhou Yuyang Zhou Yuyang Zhou Huixin Zhou Huixin Zhou Huixin Zhou Huixin Zhou Huixin Zhou Huixin Zhou Rui Li Rui Li Rui Li Rui Li Rui Li Rui Li Chen Peng Chen Peng Chen Peng Chen Peng Chen Peng Chen Peng Lilei Yu Lilei Yu Lilei Yu Lilei Yu Lilei Yu Lilei Yu Hong Jiang Hong Jiang Hong Jiang Hong Jiang Hong Jiang Hong Jiang |
author_sort | Zhongyang Yu |
collection | DOAJ |
description | ObjectivesThe neural activity of the left stellate ganglion (LSG) is closely related to the occurrence of ventricular arrhythmias (VAs). Bmal1 modulates genes associated with neural activity in the central nervous system. However, few studies indicated the role of Bmal1 in the LSG and the subsequent effect on the heart. Therefore, we aimed to investigate the influence of Bmal1 knockdown in the LSG on its neural activity and cardiac electrophysiology and to explore the mechanisms.Materials and methodsWe used adeno-associated virus (AAV) to knock down Bmal1 in the LSG. Male beagles were randomized into the Bmal1 knockdown group and the control group. After 4 weeks of injection, the LSG function, neural activity, left ventricular effective refractory period (ERP), and action potential duration (APD) were measured. Electrocardiography for 1 h was recorded for VAs analysis after myocardial ischemia. Nerve growth factor (NGF) and c-fos in the LSG were quantified by immunofluorescence. Transcriptomic analysis was performed to assess the gene expression in the LSG.ResultsBmal1 was sufficiently knocked down by AAV. Compared with the control group, heart rate variability (HRV) in the knockdown group was altered. Bmal1 knockdown inhibited neural activity and function of LSG. It also prolonged ERP as well as APD90. Ischemia-induced VAs were significantly reduced. Nerve growth factor (NGF) and c-fos in the LSG were reduced. Bmal1 knockdown led to the expression changes of genes associated with neural activity in the LSG.ConclusionBmal1 knockdown in the LSG suppresses neural activity and prevents ventricular arrhythmias after myocardial ischemia. |
first_indexed | 2024-04-11T11:15:10Z |
format | Article |
id | doaj.art-90e190781bc04672a65e5b3d5a6f6d1a |
institution | Directory Open Access Journal |
issn | 2297-055X |
language | English |
last_indexed | 2024-04-11T11:15:10Z |
publishDate | 2022-09-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Cardiovascular Medicine |
spelling | doaj.art-90e190781bc04672a65e5b3d5a6f6d1a2022-12-22T04:27:14ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-09-01910.3389/fcvm.2022.937608937608Bmal1 knockdown in the left stellate ganglion inhibits neural activity and prevents ventricular arrhythmias after myocardial ischemiaZhongyang Yu0Zhongyang Yu1Zhongyang Yu2Zhongyang Yu3Zhongyang Yu4Zhongyang Yu5Zhihao Liu6Zhihao Liu7Zhihao Liu8Zhihao Liu9Zhihao Liu10Zhihao Liu11Liying Jiao12Liying Jiao13Liying Jiao14Liying Jiao15Liying Jiao16Liying Jiao17Song Zhang18Song Zhang19Song Zhang20Song Zhang21Song Zhang22Song Zhang23Liqing Nie24Liqing Nie25Liqing Nie26Liqing Nie27Liqing Nie28Liqing Nie29Yueyi Wang30Yueyi Wang31Yueyi Wang32Yueyi Wang33Yueyi Wang34Yueyi Wang35Liping Zhou36Liping Zhou37Liping Zhou38Liping Zhou39Liping Zhou40Liping Zhou41Yuhong Wang42Yuhong Wang43Yuhong Wang44Yuhong Wang45Yuhong Wang46Yuhong Wang47Zhihao Liu48Zhihao Liu49Zhihao Liu50Zhihao Liu51Zhihao Liu52Zhihao Liu53Zihan Liu54Zihan Liu55Zihan Liu56Zihan Liu57Zihan Liu58Zihan Liu59Xiao Xu60Xiao Xu61Xiao Xu62Xiao Xu63Xiao Xu64Xiao Xu65Zeyan Li66Zeyan Li67Zeyan Li68Zeyan Li69Zeyan Li70Zeyan Li71Yuyang Zhou72Yuyang Zhou73Yuyang Zhou74Yuyang Zhou75Yuyang Zhou76Yuyang Zhou77Huixin Zhou78Huixin Zhou79Huixin Zhou80Huixin Zhou81Huixin Zhou82Huixin Zhou83Rui Li84Rui Li85Rui Li86Rui Li87Rui Li88Rui Li89Chen Peng90Chen Peng91Chen Peng92Chen Peng93Chen Peng94Chen Peng95Lilei Yu96Lilei Yu97Lilei Yu98Lilei Yu99Lilei Yu100Lilei Yu101Hong Jiang102Hong Jiang103Hong Jiang104Hong Jiang105Hong Jiang106Hong Jiang107Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Autonomic Nervous System Modulation, Wuhan, ChinaCardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, ChinaTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, ChinaCardiovascular Research Institute, Wuhan University, Wuhan, ChinaHubei Key Laboratory of Cardiology, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Autonomic Nervous System Modulation, Wuhan, ChinaCardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, ChinaTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, ChinaCardiovascular Research Institute, Wuhan University, Wuhan, ChinaHubei Key Laboratory of Cardiology, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Autonomic Nervous System Modulation, Wuhan, ChinaCardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, ChinaTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, ChinaCardiovascular Research Institute, Wuhan University, Wuhan, ChinaHubei Key Laboratory of Cardiology, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Autonomic Nervous System Modulation, Wuhan, ChinaCardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, ChinaTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, ChinaCardiovascular Research Institute, Wuhan University, Wuhan, ChinaHubei Key Laboratory of Cardiology, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Autonomic Nervous System Modulation, Wuhan, ChinaCardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, ChinaTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, ChinaCardiovascular Research Institute, Wuhan University, Wuhan, ChinaHubei Key Laboratory of Cardiology, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Autonomic Nervous System Modulation, Wuhan, ChinaCardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, ChinaTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, ChinaCardiovascular Research Institute, Wuhan University, Wuhan, ChinaHubei Key Laboratory of Cardiology, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Autonomic Nervous System Modulation, Wuhan, ChinaCardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, ChinaTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, ChinaCardiovascular Research Institute, Wuhan University, Wuhan, ChinaHubei Key Laboratory of Cardiology, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Autonomic Nervous System Modulation, Wuhan, ChinaCardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, ChinaTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, ChinaCardiovascular Research Institute, Wuhan University, Wuhan, ChinaHubei Key Laboratory of Cardiology, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Autonomic Nervous System Modulation, Wuhan, ChinaCardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, ChinaTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, ChinaCardiovascular Research Institute, Wuhan University, Wuhan, ChinaHubei Key Laboratory of Cardiology, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Autonomic Nervous System Modulation, Wuhan, ChinaCardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, ChinaTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, ChinaCardiovascular Research Institute, Wuhan University, Wuhan, ChinaHubei Key Laboratory of Cardiology, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Autonomic Nervous System Modulation, Wuhan, ChinaCardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, ChinaTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, ChinaCardiovascular Research Institute, Wuhan University, Wuhan, ChinaHubei Key Laboratory of Cardiology, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Autonomic Nervous System Modulation, Wuhan, ChinaCardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, ChinaTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, ChinaCardiovascular Research Institute, Wuhan University, Wuhan, ChinaHubei Key Laboratory of Cardiology, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Autonomic Nervous System Modulation, Wuhan, ChinaCardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, ChinaTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, ChinaCardiovascular Research Institute, Wuhan University, Wuhan, ChinaHubei Key Laboratory of Cardiology, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Autonomic Nervous System Modulation, Wuhan, ChinaCardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, ChinaTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, ChinaCardiovascular Research Institute, Wuhan University, Wuhan, ChinaHubei Key Laboratory of Cardiology, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Autonomic Nervous System Modulation, Wuhan, ChinaCardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, ChinaTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, ChinaCardiovascular Research Institute, Wuhan University, Wuhan, ChinaHubei Key Laboratory of Cardiology, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Autonomic Nervous System Modulation, Wuhan, ChinaCardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, ChinaTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, ChinaCardiovascular Research Institute, Wuhan University, Wuhan, ChinaHubei Key Laboratory of Cardiology, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Autonomic Nervous System Modulation, Wuhan, ChinaCardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, ChinaTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, ChinaCardiovascular Research Institute, Wuhan University, Wuhan, ChinaHubei Key Laboratory of Cardiology, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Autonomic Nervous System Modulation, Wuhan, ChinaCardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, ChinaTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, ChinaCardiovascular Research Institute, Wuhan University, Wuhan, ChinaHubei Key Laboratory of Cardiology, Wuhan, ChinaObjectivesThe neural activity of the left stellate ganglion (LSG) is closely related to the occurrence of ventricular arrhythmias (VAs). Bmal1 modulates genes associated with neural activity in the central nervous system. However, few studies indicated the role of Bmal1 in the LSG and the subsequent effect on the heart. Therefore, we aimed to investigate the influence of Bmal1 knockdown in the LSG on its neural activity and cardiac electrophysiology and to explore the mechanisms.Materials and methodsWe used adeno-associated virus (AAV) to knock down Bmal1 in the LSG. Male beagles were randomized into the Bmal1 knockdown group and the control group. After 4 weeks of injection, the LSG function, neural activity, left ventricular effective refractory period (ERP), and action potential duration (APD) were measured. Electrocardiography for 1 h was recorded for VAs analysis after myocardial ischemia. Nerve growth factor (NGF) and c-fos in the LSG were quantified by immunofluorescence. Transcriptomic analysis was performed to assess the gene expression in the LSG.ResultsBmal1 was sufficiently knocked down by AAV. Compared with the control group, heart rate variability (HRV) in the knockdown group was altered. Bmal1 knockdown inhibited neural activity and function of LSG. It also prolonged ERP as well as APD90. Ischemia-induced VAs were significantly reduced. Nerve growth factor (NGF) and c-fos in the LSG were reduced. Bmal1 knockdown led to the expression changes of genes associated with neural activity in the LSG.ConclusionBmal1 knockdown in the LSG suppresses neural activity and prevents ventricular arrhythmias after myocardial ischemia.https://www.frontiersin.org/articles/10.3389/fcvm.2022.937608/fullBmal1left stellate ganglionmyocardial ischemiaventricular arrhythmiastranscriptomics |
spellingShingle | Zhongyang Yu Zhongyang Yu Zhongyang Yu Zhongyang Yu Zhongyang Yu Zhongyang Yu Zhihao Liu Zhihao Liu Zhihao Liu Zhihao Liu Zhihao Liu Zhihao Liu Liying Jiao Liying Jiao Liying Jiao Liying Jiao Liying Jiao Liying Jiao Song Zhang Song Zhang Song Zhang Song Zhang Song Zhang Song Zhang Liqing Nie Liqing Nie Liqing Nie Liqing Nie Liqing Nie Liqing Nie Yueyi Wang Yueyi Wang Yueyi Wang Yueyi Wang Yueyi Wang Yueyi Wang Liping Zhou Liping Zhou Liping Zhou Liping Zhou Liping Zhou Liping Zhou Yuhong Wang Yuhong Wang Yuhong Wang Yuhong Wang Yuhong Wang Yuhong Wang Zhihao Liu Zhihao Liu Zhihao Liu Zhihao Liu Zhihao Liu Zhihao Liu Zihan Liu Zihan Liu Zihan Liu Zihan Liu Zihan Liu Zihan Liu Xiao Xu Xiao Xu Xiao Xu Xiao Xu Xiao Xu Xiao Xu Zeyan Li Zeyan Li Zeyan Li Zeyan Li Zeyan Li Zeyan Li Yuyang Zhou Yuyang Zhou Yuyang Zhou Yuyang Zhou Yuyang Zhou Yuyang Zhou Huixin Zhou Huixin Zhou Huixin Zhou Huixin Zhou Huixin Zhou Huixin Zhou Rui Li Rui Li Rui Li Rui Li Rui Li Rui Li Chen Peng Chen Peng Chen Peng Chen Peng Chen Peng Chen Peng Lilei Yu Lilei Yu Lilei Yu Lilei Yu Lilei Yu Lilei Yu Hong Jiang Hong Jiang Hong Jiang Hong Jiang Hong Jiang Hong Jiang Bmal1 knockdown in the left stellate ganglion inhibits neural activity and prevents ventricular arrhythmias after myocardial ischemia Frontiers in Cardiovascular Medicine Bmal1 left stellate ganglion myocardial ischemia ventricular arrhythmias transcriptomics |
title | Bmal1 knockdown in the left stellate ganglion inhibits neural activity and prevents ventricular arrhythmias after myocardial ischemia |
title_full | Bmal1 knockdown in the left stellate ganglion inhibits neural activity and prevents ventricular arrhythmias after myocardial ischemia |
title_fullStr | Bmal1 knockdown in the left stellate ganglion inhibits neural activity and prevents ventricular arrhythmias after myocardial ischemia |
title_full_unstemmed | Bmal1 knockdown in the left stellate ganglion inhibits neural activity and prevents ventricular arrhythmias after myocardial ischemia |
title_short | Bmal1 knockdown in the left stellate ganglion inhibits neural activity and prevents ventricular arrhythmias after myocardial ischemia |
title_sort | bmal1 knockdown in the left stellate ganglion inhibits neural activity and prevents ventricular arrhythmias after myocardial ischemia |
topic | Bmal1 left stellate ganglion myocardial ischemia ventricular arrhythmias transcriptomics |
url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.937608/full |
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bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT zeyanli bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT yuyangzhou bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT yuyangzhou bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT yuyangzhou bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT yuyangzhou bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT yuyangzhou bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT yuyangzhou bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT huixinzhou bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT huixinzhou bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT huixinzhou bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT huixinzhou bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT huixinzhou bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT huixinzhou bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT ruili bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT ruili bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT ruili bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT ruili bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT ruili bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT ruili bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT chenpeng bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT chenpeng bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT chenpeng bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT chenpeng bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT chenpeng bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT chenpeng bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT lileiyu bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT lileiyu bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT lileiyu bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT lileiyu bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT lileiyu bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT lileiyu bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT hongjiang bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT hongjiang bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT hongjiang bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT hongjiang bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT hongjiang bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia AT hongjiang bmal1knockdownintheleftstellateganglioninhibitsneuralactivityandpreventsventriculararrhythmiasaftermyocardialischemia |