Fibrinogen, Fibrinogen-like 1 and Fibrinogen-like 2 Proteins, and Their Effects
Fibrinogen (Fg) and its derivatives play a considerable role in many diseases. For example, increased levels of Fg have been found in many inflammatory diseases, such as Alzheimer’s disease, multiple sclerosis, traumatic brain injury, rheumatoid arthritis, systemic lupus erythematosus, and cancer. A...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/7/1712 |
| _version_ | 1797433830832865280 |
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| author | Nurul H. Sulimai Jason Brown David Lominadze |
| author_facet | Nurul H. Sulimai Jason Brown David Lominadze |
| author_sort | Nurul H. Sulimai |
| collection | DOAJ |
| description | Fibrinogen (Fg) and its derivatives play a considerable role in many diseases. For example, increased levels of Fg have been found in many inflammatory diseases, such as Alzheimer’s disease, multiple sclerosis, traumatic brain injury, rheumatoid arthritis, systemic lupus erythematosus, and cancer. Although associations of Fg, Fg chains, and its derivatives with various diseases have been established, their specific effects and the mechanisms of actions involved are still unclear. The present review is the first attempt to discuss the role of Fg, Fg chains, its derivatives, and other members of Fg family proteins, such as Fg-like protein 1 and 2, in inflammatory diseases and their effects in immunomodulation. |
| first_indexed | 2024-03-09T10:22:24Z |
| format | Article |
| id | doaj.art-90e1c970beeb44cca013574c61ad0f64 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T10:22:24Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-90e1c970beeb44cca013574c61ad0f642023-12-01T21:56:21ZengMDPI AGBiomedicines2227-90592022-07-01107171210.3390/biomedicines10071712Fibrinogen, Fibrinogen-like 1 and Fibrinogen-like 2 Proteins, and Their EffectsNurul H. Sulimai0Jason Brown1David Lominadze2Departments of Surgery, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USADepartments of Surgery, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USADepartments of Surgery, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USAFibrinogen (Fg) and its derivatives play a considerable role in many diseases. For example, increased levels of Fg have been found in many inflammatory diseases, such as Alzheimer’s disease, multiple sclerosis, traumatic brain injury, rheumatoid arthritis, systemic lupus erythematosus, and cancer. Although associations of Fg, Fg chains, and its derivatives with various diseases have been established, their specific effects and the mechanisms of actions involved are still unclear. The present review is the first attempt to discuss the role of Fg, Fg chains, its derivatives, and other members of Fg family proteins, such as Fg-like protein 1 and 2, in inflammatory diseases and their effects in immunomodulation.https://www.mdpi.com/2227-9059/10/7/1712fibrinfibrinogen chainsfibrinogen derivativesinflammatory diseases |
| spellingShingle | Nurul H. Sulimai Jason Brown David Lominadze Fibrinogen, Fibrinogen-like 1 and Fibrinogen-like 2 Proteins, and Their Effects Biomedicines fibrin fibrinogen chains fibrinogen derivatives inflammatory diseases |
| title | Fibrinogen, Fibrinogen-like 1 and Fibrinogen-like 2 Proteins, and Their Effects |
| title_full | Fibrinogen, Fibrinogen-like 1 and Fibrinogen-like 2 Proteins, and Their Effects |
| title_fullStr | Fibrinogen, Fibrinogen-like 1 and Fibrinogen-like 2 Proteins, and Their Effects |
| title_full_unstemmed | Fibrinogen, Fibrinogen-like 1 and Fibrinogen-like 2 Proteins, and Their Effects |
| title_short | Fibrinogen, Fibrinogen-like 1 and Fibrinogen-like 2 Proteins, and Their Effects |
| title_sort | fibrinogen fibrinogen like 1 and fibrinogen like 2 proteins and their effects |
| topic | fibrin fibrinogen chains fibrinogen derivatives inflammatory diseases |
| url | https://www.mdpi.com/2227-9059/10/7/1712 |
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