Microglial Activation Is Modulated by Captopril: in Vitro and in Vivo Studies

Microglial Activation Is Modulated by Captopril: in Vitro and in Vivo Studies

The renin-angiotensin system (RAS) is an important peripheral system involved in homeostasis modulation, with angiotensin II (Ang II) serving as the main effector hormone. The main enzyme involved in Ang II formation is angiotensin-converting enzyme (ACE). ACE inhibitors (ACEIs) such as captopril (C...

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Bibliographic Details
Main Authors: Keren Asraf, Nofar Torika, Ron N. Apte, Sigal Fleisher-Berkovich
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Alzheimer’s disease
angiotensin II
angiotensin-converting enzyme
captopril
glial inflammation
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2018.00116/full

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