Effect of Methyl–β–Cyclodextrin and Trehalose on the Freeze–Drying and Spray–Drying of Sericin for Cosmetic Purposes
Sericin is a protein extracted from <i>Bombyx mori</i> silk cocoons. Over the last decade, this wastewater product of the textile industry has shown many interesting biological properties. This protein is widely used in the cosmetic and biomedical fields. In this study, sericin has been...
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| Format: | Article |
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MDPI AG
2021-03-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/3/262 |
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| author | Lorella Giovannelli Andrea Milanesi Elena Ugazio Letizia Fracchia Lorena Segale |
| author_facet | Lorella Giovannelli Andrea Milanesi Elena Ugazio Letizia Fracchia Lorena Segale |
| author_sort | Lorella Giovannelli |
| collection | DOAJ |
| description | Sericin is a protein extracted from <i>Bombyx mori</i> silk cocoons. Over the last decade, this wastewater product of the textile industry has shown many interesting biological properties. This protein is widely used in the cosmetic and biomedical fields. In this study, sericin has been obtained via a High–Temperature High–Pressure degumming process, and was dried using the freeze–drying (fd) and spray–drying (sd) techniques. Proteins tend to collapse during drying, hence, sericin has been dried in the presence of two selected carrier agents: methyl–β–cyclodextrin and trehalose. The obtained powders have been analyzed using thermal investigation, microscopy (optical, SEM), and granulometric and spectroscopic analyses. Moreover, the percentage yield of the spray–drying process has been calculated. Both the agents were able to significantly improve the drying process, without altering the physico–chemical properties of the protein. In particular, the co–spray–drying of sericin with methyl–β–cyclodextrin and trehalose gave good process yields and furnished a powder with low moisture content and handling properties that are better than those of the other studied dried products. These characteristics seem to be appropriate and fruitful for the manufacturing of cosmetic raw materials. |
| first_indexed | 2024-03-10T13:14:40Z |
| format | Article |
| id | doaj.art-90e74a9c6bb0490ba85e384c99e82f20 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T13:14:40Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-90e74a9c6bb0490ba85e384c99e82f202023-11-21T10:30:29ZengMDPI AGPharmaceuticals1424-82472021-03-0114326210.3390/ph14030262Effect of Methyl–β–Cyclodextrin and Trehalose on the Freeze–Drying and Spray–Drying of Sericin for Cosmetic PurposesLorella Giovannelli0Andrea Milanesi1Elena Ugazio2Letizia Fracchia3Lorena Segale4Department of Pharmaceutical Sciences, Università del Piemonte Orientale, 28100 Novara, ItalyDepartment of Pharmaceutical Sciences, Università del Piemonte Orientale, 28100 Novara, ItalyDepartment of Drug Science and Technology, Università di Torino, 10125 Torino, ItalyDepartment of Pharmaceutical Sciences, Università del Piemonte Orientale, 28100 Novara, ItalyDepartment of Pharmaceutical Sciences, Università del Piemonte Orientale, 28100 Novara, ItalySericin is a protein extracted from <i>Bombyx mori</i> silk cocoons. Over the last decade, this wastewater product of the textile industry has shown many interesting biological properties. This protein is widely used in the cosmetic and biomedical fields. In this study, sericin has been obtained via a High–Temperature High–Pressure degumming process, and was dried using the freeze–drying (fd) and spray–drying (sd) techniques. Proteins tend to collapse during drying, hence, sericin has been dried in the presence of two selected carrier agents: methyl–β–cyclodextrin and trehalose. The obtained powders have been analyzed using thermal investigation, microscopy (optical, SEM), and granulometric and spectroscopic analyses. Moreover, the percentage yield of the spray–drying process has been calculated. Both the agents were able to significantly improve the drying process, without altering the physico–chemical properties of the protein. In particular, the co–spray–drying of sericin with methyl–β–cyclodextrin and trehalose gave good process yields and furnished a powder with low moisture content and handling properties that are better than those of the other studied dried products. These characteristics seem to be appropriate and fruitful for the manufacturing of cosmetic raw materials.https://www.mdpi.com/1424-8247/14/3/262cosmetic proteins<i>Bombyx mori</i> cocoonssericinmethyl–β–cyclodextrindrying techniques |
| spellingShingle | Lorella Giovannelli Andrea Milanesi Elena Ugazio Letizia Fracchia Lorena Segale Effect of Methyl–β–Cyclodextrin and Trehalose on the Freeze–Drying and Spray–Drying of Sericin for Cosmetic Purposes Pharmaceuticals cosmetic proteins <i>Bombyx mori</i> cocoons sericin methyl–β–cyclodextrin drying techniques |
| title | Effect of Methyl–β–Cyclodextrin and Trehalose on the Freeze–Drying and Spray–Drying of Sericin for Cosmetic Purposes |
| title_full | Effect of Methyl–β–Cyclodextrin and Trehalose on the Freeze–Drying and Spray–Drying of Sericin for Cosmetic Purposes |
| title_fullStr | Effect of Methyl–β–Cyclodextrin and Trehalose on the Freeze–Drying and Spray–Drying of Sericin for Cosmetic Purposes |
| title_full_unstemmed | Effect of Methyl–β–Cyclodextrin and Trehalose on the Freeze–Drying and Spray–Drying of Sericin for Cosmetic Purposes |
| title_short | Effect of Methyl–β–Cyclodextrin and Trehalose on the Freeze–Drying and Spray–Drying of Sericin for Cosmetic Purposes |
| title_sort | effect of methyl β cyclodextrin and trehalose on the freeze drying and spray drying of sericin for cosmetic purposes |
| topic | cosmetic proteins <i>Bombyx mori</i> cocoons sericin methyl–β–cyclodextrin drying techniques |
| url | https://www.mdpi.com/1424-8247/14/3/262 |
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