Low-dose celecoxib-loaded PCL fibers reverse intervertebral disc degeneration by up-regulating CHSY3 expression

Low-dose celecoxib-loaded PCL fibers reverse intervertebral disc degeneration by up-regulating CHSY3 expression

Abstract Intervertebral disc degeneration (IDD) has been identified as one of the predominant factors leading to persistent low back pain and disability in middle-aged and elderly people. Dysregulation of Prostaglandin E2 (PGE2) can cause IDD, while low-dose celecoxib can maintain PGE2 at the physio...

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Bibliographic Details
Main Authors: Yunhao Wang, Genjiang Zheng, Xiaoxing Xie, Wei Yu, Jianxi Wang, Fazhi Zang, Chen Yang, Qiangqiang Xiao, Rongcheng Zhang, Leixin Wei, Xiaodong Wu, Lei Liang, Peng Cao, Chen Xu, Jing Li, Bo Hu, Tao Zhang, Jinglei Wu, Huajiang Chen
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Nanobiotechnology
Subjects:
Intervertebral disc degeneration
Low-dose celecoxib
PGE2
CHSY3
Online Access:https://doi.org/10.1186/s12951-023-01823-4

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