Large scale controlled Fab exchange GMP process to prepare bispecific antibodies

Large scale controlled Fab exchange GMP process to prepare bispecific antibodies

Objective: Bispecific antibodies (BsAbs) have demonstrated significant therapeutic impacts for the treatment of a broad spectrum of diseases that include oncology, auto-immune, and infectious diseases. However, the large-scale production of clinical batches of bispecific antibodies still has many ch...

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Bibliographic Details
Main Authors: Xia Yao, Mingquan Xie, Yinyin Ben, Yixiang Zhu, Gaoqiang Yang, Simon Chi Wai Kwong, Zhengliang Zhang, Mark L. Chiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
bispecific antibodies
manufacturing production
controlled Fab-arm exchange
antibody expression
purification
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1298890/full

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