Treating and Managing Laryngopharyngeal Reflux Disease in the Over 65s: Evidence to Date
Jerome R Lechien1– 3 1Polyclinic of Poitiers, Elsan Hospital, Poitiers, France; 2Department of Anatomy and Experimental Oncology, Mons School of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium; 3Department of Otolaryngology–Head and Ne...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-11-01
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| Series: | Clinical Interventions in Aging |
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| Online Access: | https://www.dovepress.com/treating-and-managing-laryngopharyngeal-reflux-disease-in-the-over-65s-peer-reviewed-fulltext-article-CIA |
| _version_ | 1828291947536580608 |
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| author | Lechien JR |
| author_facet | Lechien JR |
| author_sort | Lechien JR |
| collection | DOAJ |
| description | Jerome R Lechien1– 3 1Polyclinic of Poitiers, Elsan Hospital, Poitiers, France; 2Department of Anatomy and Experimental Oncology, Mons School of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium; 3Department of Otolaryngology–Head and Neck Surgery, EpiCURA Hospital, University of Mons, Baudour, BelgiumCorrespondence: Jerome R Lechien, Department of Otolaryngology–Head and Neck Surgery, EpiCURA Hospital, University of Mons, Rue L. Cathy, Mons, Belgium, Tel +32 65 37 35 84, Email Jerome.Lechien@umons.ac.bePurpose: The clinical presentation and therapeutic outcomes of elderly patients may be different from those in younger populations, leading to additional diagnostic and therapeutic difficulties. The present study reviewed the findings on the epidemiology, and clinical, diagnostic, and therapeutic outcomes of elderly patients with laryngopharyngeal reflux (LPR).Methods: A PubMed, Cochrane Library, and Scopus literature search was conducted on the epidemiological, clinical, diagnostic, and therapeutic findings of elderly LPR patients.Findings: The prevalence of LPR in the elderly population remains unknown. From a clinical standpoint, older LPR patients report overall lower symptom scores and related quality-of-life outcomes at the time of the diagnosis. The required treatment time to obtain symptom relief appears to be longer in older compared with younger patients. Particular attention needs to be paid to prolonged medication use because the elderly population is characterized by polypharmacy and there is a higher risk of proton-pump inhibitor (PPI) interactions and adverse events. The plasma clearance of most PPIs is reduced with age, which must be considered by practitioners in the prescription of antireflux therapy.Conclusion: The clinical presentation and treatment efficacy of elderly LPR patients differ from those in younger patients. Practitioners need to carefully consider the risk of drug interactions and adverse events in elderly patients.Keywords: laryngitis, laryngopharyngeal reflux, reflux, otolaryngology, head neck surgery, gastroesophageal reflux, voice, elderly, aging, age |
| first_indexed | 2024-04-13T11:00:04Z |
| format | Article |
| id | doaj.art-90ef1f5042ca4e9481d13654c00f9f1d |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-04-13T11:00:04Z |
| publishDate | 2022-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-90ef1f5042ca4e9481d13654c00f9f1d2022-12-22T02:49:26ZengDove Medical PressClinical Interventions in Aging1178-19982022-11-01Volume 171625163379664Treating and Managing Laryngopharyngeal Reflux Disease in the Over 65s: Evidence to DateLechien JRJerome R Lechien1– 3 1Polyclinic of Poitiers, Elsan Hospital, Poitiers, France; 2Department of Anatomy and Experimental Oncology, Mons School of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium; 3Department of Otolaryngology–Head and Neck Surgery, EpiCURA Hospital, University of Mons, Baudour, BelgiumCorrespondence: Jerome R Lechien, Department of Otolaryngology–Head and Neck Surgery, EpiCURA Hospital, University of Mons, Rue L. Cathy, Mons, Belgium, Tel +32 65 37 35 84, Email Jerome.Lechien@umons.ac.bePurpose: The clinical presentation and therapeutic outcomes of elderly patients may be different from those in younger populations, leading to additional diagnostic and therapeutic difficulties. The present study reviewed the findings on the epidemiology, and clinical, diagnostic, and therapeutic outcomes of elderly patients with laryngopharyngeal reflux (LPR).Methods: A PubMed, Cochrane Library, and Scopus literature search was conducted on the epidemiological, clinical, diagnostic, and therapeutic findings of elderly LPR patients.Findings: The prevalence of LPR in the elderly population remains unknown. From a clinical standpoint, older LPR patients report overall lower symptom scores and related quality-of-life outcomes at the time of the diagnosis. The required treatment time to obtain symptom relief appears to be longer in older compared with younger patients. Particular attention needs to be paid to prolonged medication use because the elderly population is characterized by polypharmacy and there is a higher risk of proton-pump inhibitor (PPI) interactions and adverse events. The plasma clearance of most PPIs is reduced with age, which must be considered by practitioners in the prescription of antireflux therapy.Conclusion: The clinical presentation and treatment efficacy of elderly LPR patients differ from those in younger patients. Practitioners need to carefully consider the risk of drug interactions and adverse events in elderly patients.Keywords: laryngitis, laryngopharyngeal reflux, reflux, otolaryngology, head neck surgery, gastroesophageal reflux, voice, elderly, aging, agehttps://www.dovepress.com/treating-and-managing-laryngopharyngeal-reflux-disease-in-the-over-65s-peer-reviewed-fulltext-article-CIAlarynxlaryngitislaryngopharyngealrefluxotolaryngologyhead neck surgerygastroesophageal refluxvoiceelderlyagingage. |
| spellingShingle | Lechien JR Treating and Managing Laryngopharyngeal Reflux Disease in the Over 65s: Evidence to Date Clinical Interventions in Aging larynx laryngitis laryngopharyngeal reflux otolaryngology head neck surgery gastroesophageal reflux voice elderly aging age. |
| title | Treating and Managing Laryngopharyngeal Reflux Disease in the Over 65s: Evidence to Date |
| title_full | Treating and Managing Laryngopharyngeal Reflux Disease in the Over 65s: Evidence to Date |
| title_fullStr | Treating and Managing Laryngopharyngeal Reflux Disease in the Over 65s: Evidence to Date |
| title_full_unstemmed | Treating and Managing Laryngopharyngeal Reflux Disease in the Over 65s: Evidence to Date |
| title_short | Treating and Managing Laryngopharyngeal Reflux Disease in the Over 65s: Evidence to Date |
| title_sort | treating and managing laryngopharyngeal reflux disease in the over 65s evidence to date |
| topic | larynx laryngitis laryngopharyngeal reflux otolaryngology head neck surgery gastroesophageal reflux voice elderly aging age. |
| url | https://www.dovepress.com/treating-and-managing-laryngopharyngeal-reflux-disease-in-the-over-65s-peer-reviewed-fulltext-article-CIA |
| work_keys_str_mv | AT lechienjr treatingandmanaginglaryngopharyngealrefluxdiseaseintheover65sevidencetodate |