The multidimensional mechanisms of long noncoding RNA function
Abstract A major shift in our understanding of genome regulation has emerged recently. It is now apparent that the majority of cellular transcripts do not code for proteins, and many of them are long noncoding RNAs (lncRNAs). Increasingly, studies suggest that lncRNAs regulate gene expression throug...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-10-01
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| Series: | Genome Biology |
| Online Access: | http://link.springer.com/article/10.1186/s13059-017-1348-2 |
| _version_ | 1819159967150637056 |
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| author | Francesco P. Marchese Ivan Raimondi Maite Huarte |
| author_facet | Francesco P. Marchese Ivan Raimondi Maite Huarte |
| author_sort | Francesco P. Marchese |
| collection | DOAJ |
| description | Abstract A major shift in our understanding of genome regulation has emerged recently. It is now apparent that the majority of cellular transcripts do not code for proteins, and many of them are long noncoding RNAs (lncRNAs). Increasingly, studies suggest that lncRNAs regulate gene expression through diverse mechanisms. We review emerging mechanistic views of lncRNAs in gene regulation in the cell nucleus. We discuss the functional interactions that lncRNAs establish with other molecules as well as the relationship between lncRNA transcription and function. While some of these mechanisms are specific to lncRNAs, others might be shared with other types of genes. |
| first_indexed | 2024-12-22T16:48:58Z |
| format | Article |
| id | doaj.art-90ef31ae1c254dc39e67f9fe73028d74 |
| institution | Directory Open Access Journal |
| issn | 1474-760X |
| language | English |
| last_indexed | 2024-12-22T16:48:58Z |
| publishDate | 2017-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Genome Biology |
| spelling | doaj.art-90ef31ae1c254dc39e67f9fe73028d742022-12-21T18:19:39ZengBMCGenome Biology1474-760X2017-10-0118111310.1186/s13059-017-1348-2The multidimensional mechanisms of long noncoding RNA functionFrancesco P. Marchese0Ivan Raimondi1Maite Huarte2University of Navarra, Center for Applied Medical Research (CIMA)University of Navarra, Center for Applied Medical Research (CIMA)University of Navarra, Center for Applied Medical Research (CIMA)Abstract A major shift in our understanding of genome regulation has emerged recently. It is now apparent that the majority of cellular transcripts do not code for proteins, and many of them are long noncoding RNAs (lncRNAs). Increasingly, studies suggest that lncRNAs regulate gene expression through diverse mechanisms. We review emerging mechanistic views of lncRNAs in gene regulation in the cell nucleus. We discuss the functional interactions that lncRNAs establish with other molecules as well as the relationship between lncRNA transcription and function. While some of these mechanisms are specific to lncRNAs, others might be shared with other types of genes.http://link.springer.com/article/10.1186/s13059-017-1348-2 |
| spellingShingle | Francesco P. Marchese Ivan Raimondi Maite Huarte The multidimensional mechanisms of long noncoding RNA function Genome Biology |
| title | The multidimensional mechanisms of long noncoding RNA function |
| title_full | The multidimensional mechanisms of long noncoding RNA function |
| title_fullStr | The multidimensional mechanisms of long noncoding RNA function |
| title_full_unstemmed | The multidimensional mechanisms of long noncoding RNA function |
| title_short | The multidimensional mechanisms of long noncoding RNA function |
| title_sort | multidimensional mechanisms of long noncoding rna function |
| url | http://link.springer.com/article/10.1186/s13059-017-1348-2 |
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