Human Nasal Epithelial Cells Sustain Persistent SARS-CoV-2 Infection In Vitro, despite Eliciting a Prolonged Antiviral Response

Human Nasal Epithelial Cells Sustain Persistent SARS-CoV-2 Infection In Vitro, despite Eliciting a Prolonged Antiviral Response

ABSTRACT The dynamics of SARS-CoV-2 infection in COVID-19 patients are highly variable, with a subset of patients demonstrating prolonged virus shedding, which poses a significant challenge for disease management and transmission control. In this study, the long-term dynamics of SARS-CoV-2 infection...

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Bibliographic Details
Main Authors: Akshamal M. Gamage, Kai Sen Tan, Wharton O. Y. Chan, Zhe Zhang Ryan Lew, Jing Liu, Chee Wah Tan, Deepa Rajagopalan, Quy Xiao Xuan Lin, Le Min Tan, Prasanna Nori Venkatesh, Yew Kwang Ong, Mark Thong, Raymond Tzer Pin Lin, Shyam Prabhakar, De Yun Wang, Lin-Fa Wang
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:mBio
Subjects:
COVID-19
nasal epithelial cells
SARS-CoV-2
single-cell sequencing
viral persistence
Online Access:https://journals.asm.org/doi/10.1128/mbio.03436-21

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