Physiological stability and renal clearance of ultrasmall zwitterionic gold nanoparticles: Ligand length matters
Efficient renal clearance has been observed from ultrasmall zwitterionic glutathione-coated gold nanoparticles (GS-AuNPs), which have broad preclinical applications in cancer diagnosis and kidney functional imaging. However, origin of such effici...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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AIP Publishing LLC
2017-05-01
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| Series: | APL Materials |
| Online Access: | http://dx.doi.org/10.1063/1.4978381 |
| _version_ | 1811284312084971520 |
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| author | Xuhui Ning Chuanqi Peng Eric S. Li Jing Xu Rodrigo D. Vinluan III Mengxiao Yu Jie Zheng |
| author_facet | Xuhui Ning Chuanqi Peng Eric S. Li Jing Xu Rodrigo D. Vinluan III Mengxiao Yu Jie Zheng |
| author_sort | Xuhui Ning |
| collection | DOAJ |
| description | Efficient renal clearance has been observed from ultrasmall zwitterionic glutathione-coated
gold
nanoparticles
(GS-AuNPs), which have broad preclinical applications in cancer diagnosis and
kidney
functional imaging. However, origin of such efficient renal clearance is still not clear.
Herein, we conducted head-to-head comparison on physiological stability and renal
clearance of two zwitterionic luminescent AuNPs coated with cysteine and
glycine-cysteine (Cys-AuNPs and Gly-Cys-AuNPs), respectively. While both of them exhibited
similar surface
charges and the same core sizes, additional glycine slightly increased the hydrodynamic diameter of the
AuNPs by 0.4 nm but significantly enhanced physiological stability of the AuNPs as well as
altered their clearance pathways. These studies indicate that the ligand length, in
addition to surface charges and size, also plays a key role in the physiological
stability and renal clearance of ultrasmall zwitterionic inorganic NPs. |
| first_indexed | 2024-04-13T02:26:47Z |
| format | Article |
| id | doaj.art-90f1f94aaca84683865357e2d6b98b0f |
| institution | Directory Open Access Journal |
| issn | 2166-532X |
| language | English |
| last_indexed | 2024-04-13T02:26:47Z |
| publishDate | 2017-05-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | APL Materials |
| spelling | doaj.art-90f1f94aaca84683865357e2d6b98b0f2022-12-22T03:06:45ZengAIP Publishing LLCAPL Materials2166-532X2017-05-0155053406053406-610.1063/1.4978381010793APMPhysiological stability and renal clearance of ultrasmall zwitterionic gold nanoparticles: Ligand length mattersXuhui Ning0Chuanqi Peng1Eric S. Li2Jing Xu3Rodrigo D. Vinluan III4Mengxiao Yu5Jie Zheng6Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W Campbell Rd., Richardson, Texas 75080, USADepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W Campbell Rd., Richardson, Texas 75080, USADepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W Campbell Rd., Richardson, Texas 75080, USADepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W Campbell Rd., Richardson, Texas 75080, USADepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W Campbell Rd., Richardson, Texas 75080, USADepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W Campbell Rd., Richardson, Texas 75080, USADepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W Campbell Rd., Richardson, Texas 75080, USAEfficient renal clearance has been observed from ultrasmall zwitterionic glutathione-coated gold nanoparticles (GS-AuNPs), which have broad preclinical applications in cancer diagnosis and kidney functional imaging. However, origin of such efficient renal clearance is still not clear. Herein, we conducted head-to-head comparison on physiological stability and renal clearance of two zwitterionic luminescent AuNPs coated with cysteine and glycine-cysteine (Cys-AuNPs and Gly-Cys-AuNPs), respectively. While both of them exhibited similar surface charges and the same core sizes, additional glycine slightly increased the hydrodynamic diameter of the AuNPs by 0.4 nm but significantly enhanced physiological stability of the AuNPs as well as altered their clearance pathways. These studies indicate that the ligand length, in addition to surface charges and size, also plays a key role in the physiological stability and renal clearance of ultrasmall zwitterionic inorganic NPs.http://dx.doi.org/10.1063/1.4978381 |
| spellingShingle | Xuhui Ning Chuanqi Peng Eric S. Li Jing Xu Rodrigo D. Vinluan III Mengxiao Yu Jie Zheng Physiological stability and renal clearance of ultrasmall zwitterionic gold nanoparticles: Ligand length matters APL Materials |
| title | Physiological stability and renal clearance of ultrasmall zwitterionic gold
nanoparticles: Ligand length matters |
| title_full | Physiological stability and renal clearance of ultrasmall zwitterionic gold
nanoparticles: Ligand length matters |
| title_fullStr | Physiological stability and renal clearance of ultrasmall zwitterionic gold
nanoparticles: Ligand length matters |
| title_full_unstemmed | Physiological stability and renal clearance of ultrasmall zwitterionic gold
nanoparticles: Ligand length matters |
| title_short | Physiological stability and renal clearance of ultrasmall zwitterionic gold
nanoparticles: Ligand length matters |
| title_sort | physiological stability and renal clearance of ultrasmall zwitterionic gold nanoparticles ligand length matters |
| url | http://dx.doi.org/10.1063/1.4978381 |
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