Cerebral blood flow impairment and cognitive decline in heart failure
Abstract Background and Purpose Cognitive decline is an important contributor to disability in patients with chronic heart failure, affecting 25%–50% of patients. The aim of this review is to stress the importance of understanding pathophysiological mechanisms of heart failure involved in cognitive...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-06-01
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| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.2176 |
| _version_ | 1819022820854726656 |
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| author | Ana Ovsenik Matej Podbregar Andrej Fabjan |
| author_facet | Ana Ovsenik Matej Podbregar Andrej Fabjan |
| author_sort | Ana Ovsenik |
| collection | DOAJ |
| description | Abstract Background and Purpose Cognitive decline is an important contributor to disability in patients with chronic heart failure, affecting 25%–50% of patients. The aim of this review is to stress the importance of understanding pathophysiological mechanisms of heart failure involved in cognitive decline. Methods An extensive PubMed search was conducted for the literature on the basic mechanisms of cerebral blood flow regulation, the effect of cardiac dysfunction on cerebral blood flow, and possible mechanisms underlying the association between cardiac dysfunction and cognitive decline. Results Published literature supports the thesis that cardiac dysfunction leads to cerebral blood flow impairment and predisposes to cognitive decline. One of the postulated mechanisms underlying cognitive decline in chronic heart failure is chronic regional hypoperfusion of critical brain areas. Cognitive function may be further compromised by microvascular damage due to cardiovascular risk factors. Furthermore, it is implied that cerebral blood flow assessment could enable early recognition of patients at risk and help guide appropriate therapeutic strategies. Conclusion Interdisciplinary knowledge in the fields of neurology and cardiology is essential to clarify heart and brain interconnections in chronic heart failure. Understanding and identifying the basic neuropathophysiological changes in chronic heart failure could help with developing methods for early recognition of patients at risk, followed by institution of therapeutic actions to prevent or decrease cognitive decline. |
| first_indexed | 2024-12-21T04:29:05Z |
| format | Article |
| id | doaj.art-90f23e9a0b644cc58467795fbb331d93 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-21T04:29:05Z |
| publishDate | 2021-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-90f23e9a0b644cc58467795fbb331d932022-12-21T19:15:59ZengWileyBrain and Behavior2162-32792021-06-01116n/an/a10.1002/brb3.2176Cerebral blood flow impairment and cognitive decline in heart failureAna Ovsenik0Matej Podbregar1Andrej Fabjan2Faculty of Medicine University of Ljubljana Ljubljana SloveniaFaculty of Medicine Department for Internal Medicine University of Ljubljana Ljubljana SloveniaFaculty of Medicine Institute for Physiology University of Ljubljana Ljubljana SloveniaAbstract Background and Purpose Cognitive decline is an important contributor to disability in patients with chronic heart failure, affecting 25%–50% of patients. The aim of this review is to stress the importance of understanding pathophysiological mechanisms of heart failure involved in cognitive decline. Methods An extensive PubMed search was conducted for the literature on the basic mechanisms of cerebral blood flow regulation, the effect of cardiac dysfunction on cerebral blood flow, and possible mechanisms underlying the association between cardiac dysfunction and cognitive decline. Results Published literature supports the thesis that cardiac dysfunction leads to cerebral blood flow impairment and predisposes to cognitive decline. One of the postulated mechanisms underlying cognitive decline in chronic heart failure is chronic regional hypoperfusion of critical brain areas. Cognitive function may be further compromised by microvascular damage due to cardiovascular risk factors. Furthermore, it is implied that cerebral blood flow assessment could enable early recognition of patients at risk and help guide appropriate therapeutic strategies. Conclusion Interdisciplinary knowledge in the fields of neurology and cardiology is essential to clarify heart and brain interconnections in chronic heart failure. Understanding and identifying the basic neuropathophysiological changes in chronic heart failure could help with developing methods for early recognition of patients at risk, followed by institution of therapeutic actions to prevent or decrease cognitive decline.https://doi.org/10.1002/brb3.2176autonomic nervous systemcerebral autoregulationcerebral blood flowcognitive declineheart failureneurovascular coupling |
| spellingShingle | Ana Ovsenik Matej Podbregar Andrej Fabjan Cerebral blood flow impairment and cognitive decline in heart failure Brain and Behavior autonomic nervous system cerebral autoregulation cerebral blood flow cognitive decline heart failure neurovascular coupling |
| title | Cerebral blood flow impairment and cognitive decline in heart failure |
| title_full | Cerebral blood flow impairment and cognitive decline in heart failure |
| title_fullStr | Cerebral blood flow impairment and cognitive decline in heart failure |
| title_full_unstemmed | Cerebral blood flow impairment and cognitive decline in heart failure |
| title_short | Cerebral blood flow impairment and cognitive decline in heart failure |
| title_sort | cerebral blood flow impairment and cognitive decline in heart failure |
| topic | autonomic nervous system cerebral autoregulation cerebral blood flow cognitive decline heart failure neurovascular coupling |
| url | https://doi.org/10.1002/brb3.2176 |
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