Altered White Matter Integrity at Illness Onset in Adolescents With a First Episode of Psychosis
BackgroundDisruption in white matter integrity has been consistently observed in individuals with psychosis. However, whether such abnormalities are already present at illness onset or are related to downstream processes remains elusive. The study of adolescents with a recent onset of psychosis prov...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.876793/full |
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| author | Soledad Romero Soledad Romero Soledad Romero Elena de la Serna Inmaculada Baeza Inmaculada Baeza Inmaculada Baeza Inmaculada Baeza Isabel Valli José Carlos Pariente Marisol Picado Nuria Bargalló Nuria Bargalló Nuria Bargalló Gisela Sugranyes Gisela Sugranyes Gisela Sugranyes Josefina Castro-Fornieles Josefina Castro-Fornieles Josefina Castro-Fornieles Josefina Castro-Fornieles |
| author_facet | Soledad Romero Soledad Romero Soledad Romero Elena de la Serna Inmaculada Baeza Inmaculada Baeza Inmaculada Baeza Inmaculada Baeza Isabel Valli José Carlos Pariente Marisol Picado Nuria Bargalló Nuria Bargalló Nuria Bargalló Gisela Sugranyes Gisela Sugranyes Gisela Sugranyes Josefina Castro-Fornieles Josefina Castro-Fornieles Josefina Castro-Fornieles Josefina Castro-Fornieles |
| author_sort | Soledad Romero |
| collection | DOAJ |
| description | BackgroundDisruption in white matter integrity has been consistently observed in individuals with psychosis. However, whether such abnormalities are already present at illness onset or are related to downstream processes remains elusive. The study of adolescents with a recent onset of psychosis provides the opportunity to evaluate white matter integrity proximally to disease onset.MethodsTwenty-six adolescents (aged 15.9 ± 1.3 years) with a first episode of psychosis (FEP) (less than 6 months duration) were compared with 26 age and sex-matched healthy controls (HC) (16.8 ± 2 years). In participants with a FEP, clinical diagnoses were confirmed after a minimum of 1 year follow-up (main categories: schizophrenia, bipolar disorder, or schizoaffective disorder). Anatomical images and diffusion tensor sequences were acquired using a 1.5T scanner. Whole brain, voxel-wise group differences in fractional anisotropy (FA) were investigated between participants with a FEP and controls.ResultsRelative to HC, FEP participants displayed decreased FA in the right posterior cingulate gyrus, encompassing the right superior and posterior corona radiata, and the right parahippocampal gyrus, including the cingulum and fornix. FEP patients showed no areas of increased FA relative to HC. The results remained significant after controlling for medication, cannabis use and intelligence.ConclusionOur findings indicate that adolescents with recent onset of psychotic disorders show decreased white matter integrity in circuits implicated in cognitive functions and emotion regulation. |
| first_indexed | 2024-12-12T14:45:39Z |
| format | Article |
| id | doaj.art-90f243480c1a421aa063b96a4a2421f0 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-12T14:45:39Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-90f243480c1a421aa063b96a4a2421f02022-12-22T00:21:07ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-05-011310.3389/fpsyt.2022.876793876793Altered White Matter Integrity at Illness Onset in Adolescents With a First Episode of PsychosisSoledad Romero0Soledad Romero1Soledad Romero2Elena de la Serna3Inmaculada Baeza4Inmaculada Baeza5Inmaculada Baeza6Inmaculada Baeza7Isabel Valli8José Carlos Pariente9Marisol Picado10Nuria Bargalló11Nuria Bargalló12Nuria Bargalló13Gisela Sugranyes14Gisela Sugranyes15Gisela Sugranyes16Josefina Castro-Fornieles17Josefina Castro-Fornieles18Josefina Castro-Fornieles19Josefina Castro-Fornieles20Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic Barcelona, Barcelona, SpainCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, SpainInstitut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, SpainCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, SpainDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic Barcelona, Barcelona, SpainCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, SpainInstitut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, SpainDepartment of Medicine, University of Barcelona, Barcelona, SpainInstitut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, SpainInstitut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, SpainDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic Barcelona, Barcelona, SpainCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, SpainInstitut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, SpainImage Diagnostic Center, Hospital Clinic of Barcelona, Barcelona, SpainDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic Barcelona, Barcelona, SpainCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, SpainInstitut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, SpainDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic Barcelona, Barcelona, SpainCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, SpainInstitut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, SpainDepartment of Medicine, University of Barcelona, Barcelona, SpainBackgroundDisruption in white matter integrity has been consistently observed in individuals with psychosis. However, whether such abnormalities are already present at illness onset or are related to downstream processes remains elusive. The study of adolescents with a recent onset of psychosis provides the opportunity to evaluate white matter integrity proximally to disease onset.MethodsTwenty-six adolescents (aged 15.9 ± 1.3 years) with a first episode of psychosis (FEP) (less than 6 months duration) were compared with 26 age and sex-matched healthy controls (HC) (16.8 ± 2 years). In participants with a FEP, clinical diagnoses were confirmed after a minimum of 1 year follow-up (main categories: schizophrenia, bipolar disorder, or schizoaffective disorder). Anatomical images and diffusion tensor sequences were acquired using a 1.5T scanner. Whole brain, voxel-wise group differences in fractional anisotropy (FA) were investigated between participants with a FEP and controls.ResultsRelative to HC, FEP participants displayed decreased FA in the right posterior cingulate gyrus, encompassing the right superior and posterior corona radiata, and the right parahippocampal gyrus, including the cingulum and fornix. FEP patients showed no areas of increased FA relative to HC. The results remained significant after controlling for medication, cannabis use and intelligence.ConclusionOur findings indicate that adolescents with recent onset of psychotic disorders show decreased white matter integrity in circuits implicated in cognitive functions and emotion regulation.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.876793/fulldiffusionwhite matter (WM)early-onset psychosisadolescenceneurodevelopment |
| spellingShingle | Soledad Romero Soledad Romero Soledad Romero Elena de la Serna Inmaculada Baeza Inmaculada Baeza Inmaculada Baeza Inmaculada Baeza Isabel Valli José Carlos Pariente Marisol Picado Nuria Bargalló Nuria Bargalló Nuria Bargalló Gisela Sugranyes Gisela Sugranyes Gisela Sugranyes Josefina Castro-Fornieles Josefina Castro-Fornieles Josefina Castro-Fornieles Josefina Castro-Fornieles Altered White Matter Integrity at Illness Onset in Adolescents With a First Episode of Psychosis Frontiers in Psychiatry diffusion white matter (WM) early-onset psychosis adolescence neurodevelopment |
| title | Altered White Matter Integrity at Illness Onset in Adolescents With a First Episode of Psychosis |
| title_full | Altered White Matter Integrity at Illness Onset in Adolescents With a First Episode of Psychosis |
| title_fullStr | Altered White Matter Integrity at Illness Onset in Adolescents With a First Episode of Psychosis |
| title_full_unstemmed | Altered White Matter Integrity at Illness Onset in Adolescents With a First Episode of Psychosis |
| title_short | Altered White Matter Integrity at Illness Onset in Adolescents With a First Episode of Psychosis |
| title_sort | altered white matter integrity at illness onset in adolescents with a first episode of psychosis |
| topic | diffusion white matter (WM) early-onset psychosis adolescence neurodevelopment |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.876793/full |
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