Chronic stress as an emerging risk factor for the development and progression of glioma
Abstract. Gliomas tend to have a poor prognosis and are the most common primary malignant tumors of the central nervous system. Compared with patients with other cancers, glioma patients often suffer from increased levels of psychological stress, such as anxiety and fear. Chronic stress (CS) is thou...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2024-02-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000002976 |
| _version_ | 1797303330676932608 |
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| author | Lan Yi Xiang Lin Xiaoling She Wei Gao Minghua Wu Peifang Wei |
| author_facet | Lan Yi Xiang Lin Xiaoling She Wei Gao Minghua Wu Peifang Wei |
| author_sort | Lan Yi |
| collection | DOAJ |
| description | Abstract. Gliomas tend to have a poor prognosis and are the most common primary malignant tumors of the central nervous system. Compared with patients with other cancers, glioma patients often suffer from increased levels of psychological stress, such as anxiety and fear. Chronic stress (CS) is thought to impact glioma profoundly. However, because of the complex mechanisms underlying CS and variability in individual tolerance, the role of CS in glioma remains unclear. This review suggests a new proposal to redivide the stress system into two parts. Neuronal activity is dominant upstream. Stress-signaling molecules produced by the neuroendocrine system are dominant downstream. We discuss the underlying molecular mechanisms by which CS impacts glioma. Potential pharmacological treatments are also summarized from the therapeutic perspective of CS. |
| first_indexed | 2024-03-07T23:51:15Z |
| format | Article |
| id | doaj.art-90f3f5aaafae4cdc9fc314cda119f093 |
| institution | Directory Open Access Journal |
| issn | 0366-6999 2542-5641 |
| language | English |
| last_indexed | 2024-03-07T23:51:15Z |
| publishDate | 2024-02-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-90f3f5aaafae4cdc9fc314cda119f0932024-02-19T06:02:58ZengWolters KluwerChinese Medical Journal0366-69992542-56412024-02-01137439440710.1097/CM9.0000000000002976202402200-00003Chronic stress as an emerging risk factor for the development and progression of gliomaLan Yi0Xiang Lin1Xiaoling She2Wei Gao3Minghua Wu4Peifang Wei1 Institute of Cytology and Genetics, The Hengyang Key Laboratory of Cellular Stress Biology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China1 Institute of Cytology and Genetics, The Hengyang Key Laboratory of Cellular Stress Biology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China2 Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China3 Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan 410008, China3 Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan 410008, ChinaAbstract. Gliomas tend to have a poor prognosis and are the most common primary malignant tumors of the central nervous system. Compared with patients with other cancers, glioma patients often suffer from increased levels of psychological stress, such as anxiety and fear. Chronic stress (CS) is thought to impact glioma profoundly. However, because of the complex mechanisms underlying CS and variability in individual tolerance, the role of CS in glioma remains unclear. This review suggests a new proposal to redivide the stress system into two parts. Neuronal activity is dominant upstream. Stress-signaling molecules produced by the neuroendocrine system are dominant downstream. We discuss the underlying molecular mechanisms by which CS impacts glioma. Potential pharmacological treatments are also summarized from the therapeutic perspective of CS.http://journals.lww.com/10.1097/CM9.0000000000002976 |
| spellingShingle | Lan Yi Xiang Lin Xiaoling She Wei Gao Minghua Wu Peifang Wei Chronic stress as an emerging risk factor for the development and progression of glioma Chinese Medical Journal |
| title | Chronic stress as an emerging risk factor for the development and progression of glioma |
| title_full | Chronic stress as an emerging risk factor for the development and progression of glioma |
| title_fullStr | Chronic stress as an emerging risk factor for the development and progression of glioma |
| title_full_unstemmed | Chronic stress as an emerging risk factor for the development and progression of glioma |
| title_short | Chronic stress as an emerging risk factor for the development and progression of glioma |
| title_sort | chronic stress as an emerging risk factor for the development and progression of glioma |
| url | http://journals.lww.com/10.1097/CM9.0000000000002976 |
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