TS-EUROTRAIN: A European-wide investigation and training network on the aetiology and pathophysiology of Gilles de la Tourette Syndrome
Gilles de la Tourette Syndrome (GTS) is characterised by the presence of multiple motor and phonic tics with a fluctuating course of intensity, frequency and severity. Up to 90% of patients with GTS present with comorbid conditions, most commonly attention-deficit/hyperactivity disorder (ADHD) and o...
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-08-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00384/full |
| _version_ | 1819240115698925568 |
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| author | Natalie J Forde Natalie J Forde Ahmad S Kanaan Ahmad S Kanaan Joanna Widomska Shanmukha S Padmanabhuni Ester Nespoli Ester Nespoli John Alexander Juan I Rodriguez Arranz Siyan Fan Siyan Fan Siyan Fan Rayan Houssari Muhammad S Nawaz Muhammad S Nawaz Nuno R Zilhão Nuno R Zilhão Luca Pagliaroli Luca Pagliaroli Francesca Rizzo Francesca Rizzo Tamas Aranyi Tamas Aranyi Csaba Barta Tobias M Boeckers Dorret I Boomsma Dorret I Boomsma Wim R Buisman Jan K Buitelaar Jan K Buitelaar Danielle Cath Andrea Dietrich Nicole Driessen Petros Drineas Michell Dunlap Sarah Gerasch Jeffrey C Glennon Bastian Hengerer Odile A van den Heuvel Odile A van den Heuvel Cathrine Jespersgaard Harald E Möller Kirsten R Müller-Vahl Thaïra Openneer Geert Poelmans Geert Poelmans Geert Poelmans Petra J W Pouwels Jeremiah M Scharf Hreinn Stefansson Zeynep Tümer Dick Veltman Ysbrand D van der Werf Pieter J Hoekstra Andrea Ludolph Peristera Paschou |
| author_facet | Natalie J Forde Natalie J Forde Ahmad S Kanaan Ahmad S Kanaan Joanna Widomska Shanmukha S Padmanabhuni Ester Nespoli Ester Nespoli John Alexander Juan I Rodriguez Arranz Siyan Fan Siyan Fan Siyan Fan Rayan Houssari Muhammad S Nawaz Muhammad S Nawaz Nuno R Zilhão Nuno R Zilhão Luca Pagliaroli Luca Pagliaroli Francesca Rizzo Francesca Rizzo Tamas Aranyi Tamas Aranyi Csaba Barta Tobias M Boeckers Dorret I Boomsma Dorret I Boomsma Wim R Buisman Jan K Buitelaar Jan K Buitelaar Danielle Cath Andrea Dietrich Nicole Driessen Petros Drineas Michell Dunlap Sarah Gerasch Jeffrey C Glennon Bastian Hengerer Odile A van den Heuvel Odile A van den Heuvel Cathrine Jespersgaard Harald E Möller Kirsten R Müller-Vahl Thaïra Openneer Geert Poelmans Geert Poelmans Geert Poelmans Petra J W Pouwels Jeremiah M Scharf Hreinn Stefansson Zeynep Tümer Dick Veltman Ysbrand D van der Werf Pieter J Hoekstra Andrea Ludolph Peristera Paschou |
| author_sort | Natalie J Forde |
| collection | DOAJ |
| description | Gilles de la Tourette Syndrome (GTS) is characterised by the presence of multiple motor and phonic tics with a fluctuating course of intensity, frequency and severity. Up to 90% of patients with GTS present with comorbid conditions, most commonly attention-deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD), thus providing an excellent model for the exploration of shared aetiology across disorders. TS-EUROTRAIN (FP7-PEOPLE-2012-ITN, Grant Agr.No.316978) is a Marie Curie Initial Training Network (http://ts-eurotrain.eu) that aims to elucidate the complex aetiology of the onset and clinical course of GTS, investigate the neurobiological underpinnings of GTS and related disorders, translate research findings into clinical applications and establish a pan-European infrastructure for the study of GTS. This includes the challenges of (i) assembling a large genetic database for the evaluation of the genetic architecture with high statistical power; (ii) exploring the role of gene-environment interactions including the effects of epigenetic phenomena; (iii) employing endophenotype-based approaches to understand the shared aetiology between GTS, OCD and ADHD; (iv) establishing a developmental animal model for GTS; (v) gaining new insights into the neurobiological mechanisms of GTS via cross-sectional and longitudinal neuroimaging studies; and (vi) partaking in outreach activities including the dissemination of scientific knowledge about GTS to the public. Fifteen partners from academia and industry and twelve PhD candidates pursue the project. Our ultimate aims are to elucidate the complex aetiology and neurobiological underpinnings of GTS, translate research findings into clinical applications and establish Pan-European infrastructure for the study of GTS and associated disorders. |
| first_indexed | 2024-12-23T14:02:53Z |
| format | Article |
| id | doaj.art-90f6bdacaef049d58a711f485869c427 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-23T14:02:53Z |
| publishDate | 2016-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-90f6bdacaef049d58a711f485869c4272022-12-21T17:44:15ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2016-08-011010.3389/fnins.2016.00384190337TS-EUROTRAIN: A European-wide investigation and training network on the aetiology and pathophysiology of Gilles de la Tourette SyndromeNatalie J Forde0Natalie J Forde1Ahmad S Kanaan2Ahmad S Kanaan3Joanna Widomska4Shanmukha S Padmanabhuni5Ester Nespoli6Ester Nespoli7John Alexander8Juan I Rodriguez Arranz9Siyan Fan10Siyan Fan11Siyan Fan12Rayan Houssari13Muhammad S Nawaz14Muhammad S Nawaz15Nuno R Zilhão16Nuno R Zilhão17Luca Pagliaroli18Luca Pagliaroli19Francesca Rizzo20Francesca Rizzo21Tamas Aranyi22Tamas Aranyi23Csaba Barta24Tobias M Boeckers25Dorret I Boomsma26Dorret I Boomsma27Wim R Buisman28Jan K Buitelaar29Jan K Buitelaar30Danielle Cath31Andrea Dietrich32Nicole Driessen33Petros Drineas34Michell Dunlap35Sarah Gerasch36Jeffrey C Glennon37Bastian Hengerer38Odile A van den Heuvel39Odile A van den Heuvel40Cathrine Jespersgaard41Harald E Möller42Kirsten R Müller-Vahl43Thaïra Openneer44Geert Poelmans45Geert Poelmans46Geert Poelmans47Petra J W Pouwels48Jeremiah M Scharf49Hreinn Stefansson50Zeynep Tümer51Dick Veltman52Ysbrand D van der Werf53Pieter J Hoekstra54Andrea Ludolph55Peristera Paschou56University of Groningen, University Medical Center GroningenDonders Institute for Brain, Cognition and Behaviour, Radboud University Medical CenterClinic of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical SchoolMax Planck Institute for Human Cognitive and Brain SciencesDonders Institute for Brain, Cognition and Behaviour, Radboud University Medical CenterDemocritus University of ThraceBoehringer Ingelheim Pharma GmbH & Co. KGUniversity of UlmDemocritus University of ThraceApplied Human Molecular Genetics, Kennedy CenterUtrecht UniversityVU University Medical Center (VUmc)VU University Medical Center (VUmc)Applied Human Molecular Genetics, Kennedy CenterdeCODE Genetics/AmgenUniversity of IcelandUtrecht UniversityVU UniversityInstitute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis UniversityInstitute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of SciencesUniversity of UlmInstitute for Anatomy and Cell Biology, Ulm UniversityInstitute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of SciencesUniversité d'Angers, BNMI (INSERM 1083 / CNRS 6214)Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis UniversityInstitute for Anatomy and Cell Biology, Ulm UniversityVU UniversityEMGO+ Institute for Health and Care Research, VU University Medical CentreStichting Gilles de la TouretteDonders Institute for Brain, Cognition and Behaviour, Radboud University Medical CenterKarakter Child and Adolescent Psychiatry University CentreUtrecht UniversityUniversity of Groningen, University Medical Center GroningenDonders Institute for Brain, Cognition and Behaviour, Radboud University Medical CenterRensselaer Polytechnic InstituteTourette-Gesellschaft Deutschland e.V.Clinic of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical SchoolDonders Institute for Brain, Cognition and Behaviour, Radboud University Medical CenterBoehringer Ingelheim Pharma GmbH & Co. KGVU University Medical Center (VUmc)VU University Medical Center (VUmc)Applied Human Molecular Genetics, Kennedy CenterMax Planck Institute for Human Cognitive and Brain SciencesClinic of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical SchoolUniversity of Groningen, University Medical Center GroningenDonders Institute for Brain, Cognition and Behaviour, Radboud University Medical CenterRadboud University Medical CenterDonders Institute for Brain, Cognition and Behaviour, Radboud Institute for Molecular Life Sciences, Radboud UniversityVU University Medical Center (VUmc)Harvard Medical School, Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General HospitaldeCODE Genetics/AmgenApplied Human Molecular Genetics, Kennedy CenterVU University Medical Center (VUmc)VU University Medical Center (VUmc)University of Groningen, University Medical Center GroningenUniversity of UlmDemocritus University of ThraceGilles de la Tourette Syndrome (GTS) is characterised by the presence of multiple motor and phonic tics with a fluctuating course of intensity, frequency and severity. Up to 90% of patients with GTS present with comorbid conditions, most commonly attention-deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD), thus providing an excellent model for the exploration of shared aetiology across disorders. TS-EUROTRAIN (FP7-PEOPLE-2012-ITN, Grant Agr.No.316978) is a Marie Curie Initial Training Network (http://ts-eurotrain.eu) that aims to elucidate the complex aetiology of the onset and clinical course of GTS, investigate the neurobiological underpinnings of GTS and related disorders, translate research findings into clinical applications and establish a pan-European infrastructure for the study of GTS. This includes the challenges of (i) assembling a large genetic database for the evaluation of the genetic architecture with high statistical power; (ii) exploring the role of gene-environment interactions including the effects of epigenetic phenomena; (iii) employing endophenotype-based approaches to understand the shared aetiology between GTS, OCD and ADHD; (iv) establishing a developmental animal model for GTS; (v) gaining new insights into the neurobiological mechanisms of GTS via cross-sectional and longitudinal neuroimaging studies; and (vi) partaking in outreach activities including the dissemination of scientific knowledge about GTS to the public. Fifteen partners from academia and industry and twelve PhD candidates pursue the project. Our ultimate aims are to elucidate the complex aetiology and neurobiological underpinnings of GTS, translate research findings into clinical applications and establish Pan-European infrastructure for the study of GTS and associated disorders.http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00384/fullGeneticsNeuroimagingGilles de la Tourette syndromeAnimal ModelsAetiologyTourette Disorder |
| spellingShingle | Natalie J Forde Natalie J Forde Ahmad S Kanaan Ahmad S Kanaan Joanna Widomska Shanmukha S Padmanabhuni Ester Nespoli Ester Nespoli John Alexander Juan I Rodriguez Arranz Siyan Fan Siyan Fan Siyan Fan Rayan Houssari Muhammad S Nawaz Muhammad S Nawaz Nuno R Zilhão Nuno R Zilhão Luca Pagliaroli Luca Pagliaroli Francesca Rizzo Francesca Rizzo Tamas Aranyi Tamas Aranyi Csaba Barta Tobias M Boeckers Dorret I Boomsma Dorret I Boomsma Wim R Buisman Jan K Buitelaar Jan K Buitelaar Danielle Cath Andrea Dietrich Nicole Driessen Petros Drineas Michell Dunlap Sarah Gerasch Jeffrey C Glennon Bastian Hengerer Odile A van den Heuvel Odile A van den Heuvel Cathrine Jespersgaard Harald E Möller Kirsten R Müller-Vahl Thaïra Openneer Geert Poelmans Geert Poelmans Geert Poelmans Petra J W Pouwels Jeremiah M Scharf Hreinn Stefansson Zeynep Tümer Dick Veltman Ysbrand D van der Werf Pieter J Hoekstra Andrea Ludolph Peristera Paschou TS-EUROTRAIN: A European-wide investigation and training network on the aetiology and pathophysiology of Gilles de la Tourette Syndrome Frontiers in Neuroscience Genetics Neuroimaging Gilles de la Tourette syndrome Animal Models Aetiology Tourette Disorder |
| title | TS-EUROTRAIN: A European-wide investigation and training network on the aetiology and pathophysiology of Gilles de la Tourette Syndrome |
| title_full | TS-EUROTRAIN: A European-wide investigation and training network on the aetiology and pathophysiology of Gilles de la Tourette Syndrome |
| title_fullStr | TS-EUROTRAIN: A European-wide investigation and training network on the aetiology and pathophysiology of Gilles de la Tourette Syndrome |
| title_full_unstemmed | TS-EUROTRAIN: A European-wide investigation and training network on the aetiology and pathophysiology of Gilles de la Tourette Syndrome |
| title_short | TS-EUROTRAIN: A European-wide investigation and training network on the aetiology and pathophysiology of Gilles de la Tourette Syndrome |
| title_sort | ts eurotrain a european wide investigation and training network on the aetiology and pathophysiology of gilles de la tourette syndrome |
| topic | Genetics Neuroimaging Gilles de la Tourette syndrome Animal Models Aetiology Tourette Disorder |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00384/full |
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