F(ab')2 antibody fragments against Trypanosoma cruzi calreticulin inhibit its interaction with the first component of human complement

F(ab')2 antibody fragments against Trypanosoma cruzi calreticulin inhibit its interaction with the first component of human complement

Trypanosoma cruzi calreticulin (TcCRT), described in our laboratory, retains several important functional features from its vertebrate homologues. We have shown that recombinant TcCRT inhibits the human complement system when it binds to the collagenous portion of C1q. The generation of classical pa...

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Bibliographic Details
Main Authors: LORENA AGUILAR, GALIA RAMÍREZ, CAROLINA VALCK, MARÍA C MOLINA, ÁLVARO ROJAS, WILHELM SCHWAEBLE, VIVIANA FERREIRA, ARTURO FERREIRA
Format: Article
Language:English
Published: BMC 2005-01-01
Series:Biological Research
Subjects:
calreticulin
C1q
F(ab')2 antibody fragments
Trypanosoma cruzi
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200008

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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200008

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