Relationship of Soluble Klotho and Early Stage of Diabetic Nephropathy: A Systematic Review and Meta-Analysis
BackgroundDiabetic nephropathy (DN) is a chronic microvascular complication caused by long-term hyperglycemia in patients with diabetes and an important cause of end-stage renal disease. Although some studies have shown that soluble Klotho(sKlotho) levels of patients with DN are lower than those wit...
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| Format: | Article |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.902765/full |
| _version_ | 1831516897153122304 |
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| author | Caihong Xin Caihong Xin Xin Sun Zheng Li Tianshu Gao |
| author_facet | Caihong Xin Caihong Xin Xin Sun Zheng Li Tianshu Gao |
| author_sort | Caihong Xin |
| collection | DOAJ |
| description | BackgroundDiabetic nephropathy (DN) is a chronic microvascular complication caused by long-term hyperglycemia in patients with diabetes and an important cause of end-stage renal disease. Although some studies have shown that soluble Klotho(sKlotho) levels of patients with DN are lower than those without DN, in the early stage of patients with DN with normal renal function and albuminuria, the change in sKlotho is still controversial.AimThis meta-analysis was conducted to statistically evaluate sKlotho levels in patients with DN.MethodsWe searched the following electronic databases: Web of Science, Embase, PubMed, Google Scholar, and China National Knowledge Infrastructure (CNKI). The following search terms were used for the title or abstract: “diabetic kidney disease”, “diabetic nephropathy”, OR “DN” in combination with “Klotho”. The meta-analysis results were presented as standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs).ResultsFourteen articles were included in the meta-analysis. In our meta-analysis, we found that the sKlotho level in patients with DN was significantly lower than that in patients without DN (SMD: -1.52, 95% CI [-2.24, -0.80]), and it was also significantly lower in the early stage of DN (SMD: -1.65, 95% CI [-2.60, -0.70]).ConclusionsThis systematic review was the first to evaluate the relationship between sKlotho levels and DN. The sKlotho level was significantly lower in the early stages of DN, indicating that sKlotho might be a new biomarker of DN in the future. |
| first_indexed | 2024-04-12T17:36:53Z |
| format | Article |
| id | doaj.art-90f8716a53f84e9ca4731251a8b9601b |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T17:36:53Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-90f8716a53f84e9ca4731251a8b9601b2022-12-22T03:22:56ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-05-011310.3389/fendo.2022.902765902765Relationship of Soluble Klotho and Early Stage of Diabetic Nephropathy: A Systematic Review and Meta-AnalysisCaihong Xin0Caihong Xin1Xin Sun2Zheng Li3Tianshu Gao4Liaoning University of Traditional Chinese Medicine, Shenyang, ChinaDepartment of Endocrinology and Metabolism, Fourth People’s Hospital of Shenyang, Shenyang, ChinaDepartment of Endocrinology and Metabolism, First Affiliated Hospital of Soochow University, Suzhou, ChinaLiaoning University of Traditional Chinese Medicine, Shenyang, ChinaLiaoning University of Traditional Chinese Medicine, Shenyang, ChinaBackgroundDiabetic nephropathy (DN) is a chronic microvascular complication caused by long-term hyperglycemia in patients with diabetes and an important cause of end-stage renal disease. Although some studies have shown that soluble Klotho(sKlotho) levels of patients with DN are lower than those without DN, in the early stage of patients with DN with normal renal function and albuminuria, the change in sKlotho is still controversial.AimThis meta-analysis was conducted to statistically evaluate sKlotho levels in patients with DN.MethodsWe searched the following electronic databases: Web of Science, Embase, PubMed, Google Scholar, and China National Knowledge Infrastructure (CNKI). The following search terms were used for the title or abstract: “diabetic kidney disease”, “diabetic nephropathy”, OR “DN” in combination with “Klotho”. The meta-analysis results were presented as standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs).ResultsFourteen articles were included in the meta-analysis. In our meta-analysis, we found that the sKlotho level in patients with DN was significantly lower than that in patients without DN (SMD: -1.52, 95% CI [-2.24, -0.80]), and it was also significantly lower in the early stage of DN (SMD: -1.65, 95% CI [-2.60, -0.70]).ConclusionsThis systematic review was the first to evaluate the relationship between sKlotho levels and DN. The sKlotho level was significantly lower in the early stages of DN, indicating that sKlotho might be a new biomarker of DN in the future.https://www.frontiersin.org/articles/10.3389/fendo.2022.902765/fullKlothodiabetic nephropathyDNmeta- analysesSystematic (Literature) Review |
| spellingShingle | Caihong Xin Caihong Xin Xin Sun Zheng Li Tianshu Gao Relationship of Soluble Klotho and Early Stage of Diabetic Nephropathy: A Systematic Review and Meta-Analysis Frontiers in Endocrinology Klotho diabetic nephropathy DN meta- analyses Systematic (Literature) Review |
| title | Relationship of Soluble Klotho and Early Stage of Diabetic Nephropathy: A Systematic Review and Meta-Analysis |
| title_full | Relationship of Soluble Klotho and Early Stage of Diabetic Nephropathy: A Systematic Review and Meta-Analysis |
| title_fullStr | Relationship of Soluble Klotho and Early Stage of Diabetic Nephropathy: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Relationship of Soluble Klotho and Early Stage of Diabetic Nephropathy: A Systematic Review and Meta-Analysis |
| title_short | Relationship of Soluble Klotho and Early Stage of Diabetic Nephropathy: A Systematic Review and Meta-Analysis |
| title_sort | relationship of soluble klotho and early stage of diabetic nephropathy a systematic review and meta analysis |
| topic | Klotho diabetic nephropathy DN meta- analyses Systematic (Literature) Review |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.902765/full |
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