Development of the Vestibular Lamina in Human Embryos: Morphogenesis and Vestibule Formation
The vestibular lamina (VL) is a transient developmental structure that forms the lip furrow, creating a gap between the lips/cheeks and teeth (oral vestibule). Surprisingly, little is known about the development of the VL and its relationship to the adjacent dental lamina (DL), which forms the teeth...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-07-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2020.00753/full |
| _version_ | 1818112854098706432 |
|---|---|
| author | Tengyang Qiu Tathyane H. N. Teshima Maria Hovorakova Maria Hovorakova Abigail S. Tucker Abigail S. Tucker |
| author_facet | Tengyang Qiu Tathyane H. N. Teshima Maria Hovorakova Maria Hovorakova Abigail S. Tucker Abigail S. Tucker |
| author_sort | Tengyang Qiu |
| collection | DOAJ |
| description | The vestibular lamina (VL) is a transient developmental structure that forms the lip furrow, creating a gap between the lips/cheeks and teeth (oral vestibule). Surprisingly, little is known about the development of the VL and its relationship to the adjacent dental lamina (DL), which forms the teeth. In some congenital disorders, such as Ellis-van Creveld (EVC) syndrome, development of the VL is disrupted and multiple supernumerary frenula form, physically linking the lips and teeth. Here, we assess the normal development of the VL in human embryos from 6.5 (CS19) to 13 weeks of development, showing the close relationship between the VL and DL, from initiation to differentiation. In the anterior lower region, the two structures arise from the same epithelial thickening. The VL then undergoes complex morphogenetic changes during development, forming a branched structure that separates to create the vestibule. Changing expression of keratins highlight the differentiation patterns in the VL, with fissure formation linked to the onset of filaggrin. Apoptosis is involved in removal of the central portion of the VL to create a broad furrow between the future cheek and gum. This research forms an essential base to further explore developmental defects in this part of the oral cavity. |
| first_indexed | 2024-12-11T03:25:33Z |
| format | Article |
| id | doaj.art-90f9fd6473a1433b8f59d128d3cde504 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-11T03:25:33Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-90f9fd6473a1433b8f59d128d3cde5042022-12-22T01:22:31ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-07-011110.3389/fphys.2020.00753553228Development of the Vestibular Lamina in Human Embryos: Morphogenesis and Vestibule FormationTengyang Qiu0Tathyane H. N. Teshima1Maria Hovorakova2Maria Hovorakova3Abigail S. Tucker4Abigail S. Tucker5Centre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral and Craniofacial Sciences, King’s College London, London, United KingdomCentre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral and Craniofacial Sciences, King’s College London, London, United KingdomInstitute of Histology and Embryology, First Faculty of Medicine, Charles University in Prague, Prague, CzechiaInstitute of Experimental Medicine, Czech Academy of Sciences, Prague, CzechiaCentre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral and Craniofacial Sciences, King’s College London, London, United KingdomInstitute of Experimental Medicine, Czech Academy of Sciences, Prague, CzechiaThe vestibular lamina (VL) is a transient developmental structure that forms the lip furrow, creating a gap between the lips/cheeks and teeth (oral vestibule). Surprisingly, little is known about the development of the VL and its relationship to the adjacent dental lamina (DL), which forms the teeth. In some congenital disorders, such as Ellis-van Creveld (EVC) syndrome, development of the VL is disrupted and multiple supernumerary frenula form, physically linking the lips and teeth. Here, we assess the normal development of the VL in human embryos from 6.5 (CS19) to 13 weeks of development, showing the close relationship between the VL and DL, from initiation to differentiation. In the anterior lower region, the two structures arise from the same epithelial thickening. The VL then undergoes complex morphogenetic changes during development, forming a branched structure that separates to create the vestibule. Changing expression of keratins highlight the differentiation patterns in the VL, with fissure formation linked to the onset of filaggrin. Apoptosis is involved in removal of the central portion of the VL to create a broad furrow between the future cheek and gum. This research forms an essential base to further explore developmental defects in this part of the oral cavity.https://www.frontiersin.org/article/10.3389/fphys.2020.00753/fulldental pathologieskeratinepithelial differentiationapoptosisoral mucosahuman development |
| spellingShingle | Tengyang Qiu Tathyane H. N. Teshima Maria Hovorakova Maria Hovorakova Abigail S. Tucker Abigail S. Tucker Development of the Vestibular Lamina in Human Embryos: Morphogenesis and Vestibule Formation Frontiers in Physiology dental pathologies keratin epithelial differentiation apoptosis oral mucosa human development |
| title | Development of the Vestibular Lamina in Human Embryos: Morphogenesis and Vestibule Formation |
| title_full | Development of the Vestibular Lamina in Human Embryos: Morphogenesis and Vestibule Formation |
| title_fullStr | Development of the Vestibular Lamina in Human Embryos: Morphogenesis and Vestibule Formation |
| title_full_unstemmed | Development of the Vestibular Lamina in Human Embryos: Morphogenesis and Vestibule Formation |
| title_short | Development of the Vestibular Lamina in Human Embryos: Morphogenesis and Vestibule Formation |
| title_sort | development of the vestibular lamina in human embryos morphogenesis and vestibule formation |
| topic | dental pathologies keratin epithelial differentiation apoptosis oral mucosa human development |
| url | https://www.frontiersin.org/article/10.3389/fphys.2020.00753/full |
| work_keys_str_mv | AT tengyangqiu developmentofthevestibularlaminainhumanembryosmorphogenesisandvestibuleformation AT tathyanehnteshima developmentofthevestibularlaminainhumanembryosmorphogenesisandvestibuleformation AT mariahovorakova developmentofthevestibularlaminainhumanembryosmorphogenesisandvestibuleformation AT mariahovorakova developmentofthevestibularlaminainhumanembryosmorphogenesisandvestibuleformation AT abigailstucker developmentofthevestibularlaminainhumanembryosmorphogenesisandvestibuleformation AT abigailstucker developmentofthevestibularlaminainhumanembryosmorphogenesisandvestibuleformation |