Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10
Neuronal cells depend on mitochondrial oxidative phosphorylation for most of their energy needs and therefore are at a particular risk for oxidative stress. Mitochondria play an important role in energy production and oxidative stress-induced apoptosis. In the present study, we have demonstrated tha...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2005-04-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996104002712 |
| _version_ | 1818623357384392704 |
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| author | M. Somayajulu S. McCarthy M. Hung M. Sikorska H. Borowy-Borowski S. Pandey |
| author_facet | M. Somayajulu S. McCarthy M. Hung M. Sikorska H. Borowy-Borowski S. Pandey |
| author_sort | M. Somayajulu |
| collection | DOAJ |
| description | Neuronal cells depend on mitochondrial oxidative phosphorylation for most of their energy needs and therefore are at a particular risk for oxidative stress. Mitochondria play an important role in energy production and oxidative stress-induced apoptosis. In the present study, we have demonstrated that external oxidative stress induces mitochondrial dysfunction leading to increased ROS generation and ultimately apoptotic cell death in neuronal cells. Furthermore, we have investigated the role of Coenzyme Q10 as a neuroprotective agent. Coenzyme Q10 is a component of the mitochondrial respiratory chain and a potent anti-oxidant. Our results indicate that total cellular ROS generation was inhibited by Coenzyme Q10. Further, pre-treatment with Coenzyme Q10 maintained mitochondrial membrane potential during oxidative stress and reduced the amount of mitochondrial ROS generation. Our study suggests that water-soluble Coenzyme Q10 acts by stabilizing the mitochondrial membrane when neuronal cells are subjected to oxidative stress. Therefore, Coenzyme Q10 has the potential to be used as a therapeutic intervention for neurodegenerative diseases. |
| first_indexed | 2024-12-16T18:39:47Z |
| format | Article |
| id | doaj.art-90fa6382360e47b194499d1e8d42b796 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-16T18:39:47Z |
| publishDate | 2005-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-90fa6382360e47b194499d1e8d42b7962022-12-21T22:21:05ZengElsevierNeurobiology of Disease1095-953X2005-04-01183618627Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10M. Somayajulu0S. McCarthy1M. Hung2M. Sikorska3H. Borowy-Borowski4S. Pandey5Department of Biochemistry and Chemistry, 277-1 Essex Hall, University of Windsor, 401 Sunset Avenue, Windsor, ON, Canada N9B 3P4Department of Biochemistry and Chemistry, 277-1 Essex Hall, University of Windsor, 401 Sunset Avenue, Windsor, ON, Canada N9B 3P4Department of Biochemistry and Chemistry, 277-1 Essex Hall, University of Windsor, 401 Sunset Avenue, Windsor, ON, Canada N9B 3P4National Research Council, Ottawa, CanadaNational Research Council, Ottawa, CanadaDepartment of Biochemistry and Chemistry, 277-1 Essex Hall, University of Windsor, 401 Sunset Avenue, Windsor, ON, Canada N9B 3P4; Corresponding author. Fax: +1 519 973 7098.Neuronal cells depend on mitochondrial oxidative phosphorylation for most of their energy needs and therefore are at a particular risk for oxidative stress. Mitochondria play an important role in energy production and oxidative stress-induced apoptosis. In the present study, we have demonstrated that external oxidative stress induces mitochondrial dysfunction leading to increased ROS generation and ultimately apoptotic cell death in neuronal cells. Furthermore, we have investigated the role of Coenzyme Q10 as a neuroprotective agent. Coenzyme Q10 is a component of the mitochondrial respiratory chain and a potent anti-oxidant. Our results indicate that total cellular ROS generation was inhibited by Coenzyme Q10. Further, pre-treatment with Coenzyme Q10 maintained mitochondrial membrane potential during oxidative stress and reduced the amount of mitochondrial ROS generation. Our study suggests that water-soluble Coenzyme Q10 acts by stabilizing the mitochondrial membrane when neuronal cells are subjected to oxidative stress. Therefore, Coenzyme Q10 has the potential to be used as a therapeutic intervention for neurodegenerative diseases.http://www.sciencedirect.com/science/article/pii/S0969996104002712ApoptosisROSOxidative stressNeurodegenerationCoenzyme Q10 |
| spellingShingle | M. Somayajulu S. McCarthy M. Hung M. Sikorska H. Borowy-Borowski S. Pandey Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10 Neurobiology of Disease Apoptosis ROS Oxidative stress Neurodegeneration Coenzyme Q10 |
| title | Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10 |
| title_full | Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10 |
| title_fullStr | Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10 |
| title_full_unstemmed | Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10 |
| title_short | Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10 |
| title_sort | role of mitochondria in neuronal cell death induced by oxidative stress neuroprotection by coenzyme q10 |
| topic | Apoptosis ROS Oxidative stress Neurodegeneration Coenzyme Q10 |
| url | http://www.sciencedirect.com/science/article/pii/S0969996104002712 |
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