Cord blood Bilirubin as a predictor of Neonatal Hyperbilirubinemia
Background: Bilirubin is an antioxidant that protects newborns against free radicals during the first days of their lives, but at high levels is neurotoxic and causes brain damage. In this study we aimed to determine whether the measurement of bilirubin level in noninvasively taken cord blood could...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Slovenian Medical Association
2010-06-01
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| Series: | Zdravniški Vestnik |
| Online Access: | http://vestnik.szd.si/index.php/ZdravVest/article/view/267 |
| _version_ | 1811195271835549696 |
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| author | Danijela Furlan Ana Ilijaš-Trofenik Vladimir Weber Zlata Felc Borut Bratanič Jana Lukač-Bajalo |
| author_facet | Danijela Furlan Ana Ilijaš-Trofenik Vladimir Weber Zlata Felc Borut Bratanič Jana Lukač-Bajalo |
| author_sort | Danijela Furlan |
| collection | DOAJ |
| description | Background: Bilirubin is an antioxidant that
protects newborns against free radicals during
the first days of their lives, but at high levels
is neurotoxic and causes brain damage. In
this study we aimed to determine whether the
measurement of bilirubin level in noninvasively
taken cord blood could be a predictor of a pathological
jaundice requiring medical treatment.
Methods: Cord blood and a control sample
taken on the third day of life were taken from
185 healthy full-term newborns of both genders.
Bilirubin levels were determined according to
the Jandrassik-Grof method. Statistical characteristics
were calculated using statistic programs
ANOVA and t-test.
Results: 117 (63.2 %) of the newborns had physiological
jaundice with 28 ± 7.8 μmol/L bilirubin
in cord blood, and 68 (36.8 %) had pathological
jaundice with 35 ± 7.8 μmol/L bilirubin. 20
(10.8 %) newborns had been treated by phototherapy,
and had levels of 40 ± 8.5 μmol/L bilirubin.
Differences in cord blood bilirubin levels
between groups were statistically significant
(p < 0.001). Taking a cut-off value of 28 μmol/L
cord blood bilirubin level, pathological jaundice
can be predicted by 85.3 % and whether newborns
require treatment or not by 100 % clinical
sensitivity.
Conclusions: The results of our study confirm
that measurement of cord blood bilirubin level
can be used as a screening test for predicting the
development of pathological jaundice that requires
medical treatment. |
| first_indexed | 2024-04-12T00:40:40Z |
| format | Article |
| id | doaj.art-90fde4f114084281b7fe1f5a67ec3be7 |
| institution | Directory Open Access Journal |
| issn | 1318-0347 1581-0224 |
| language | English |
| last_indexed | 2024-04-12T00:40:40Z |
| publishDate | 2010-06-01 |
| publisher | Slovenian Medical Association |
| record_format | Article |
| series | Zdravniški Vestnik |
| spelling | doaj.art-90fde4f114084281b7fe1f5a67ec3be72022-12-22T03:55:01ZengSlovenian Medical AssociationZdravniški Vestnik1318-03471581-02242010-06-01796159Cord blood Bilirubin as a predictor of Neonatal HyperbilirubinemiaDanijela FurlanAna Ilijaš-TrofenikVladimir WeberZlata FelcBorut BrataničJana Lukač-BajaloBackground: Bilirubin is an antioxidant that protects newborns against free radicals during the first days of their lives, but at high levels is neurotoxic and causes brain damage. In this study we aimed to determine whether the measurement of bilirubin level in noninvasively taken cord blood could be a predictor of a pathological jaundice requiring medical treatment. Methods: Cord blood and a control sample taken on the third day of life were taken from 185 healthy full-term newborns of both genders. Bilirubin levels were determined according to the Jandrassik-Grof method. Statistical characteristics were calculated using statistic programs ANOVA and t-test. Results: 117 (63.2 %) of the newborns had physiological jaundice with 28 ± 7.8 μmol/L bilirubin in cord blood, and 68 (36.8 %) had pathological jaundice with 35 ± 7.8 μmol/L bilirubin. 20 (10.8 %) newborns had been treated by phototherapy, and had levels of 40 ± 8.5 μmol/L bilirubin. Differences in cord blood bilirubin levels between groups were statistically significant (p < 0.001). Taking a cut-off value of 28 μmol/L cord blood bilirubin level, pathological jaundice can be predicted by 85.3 % and whether newborns require treatment or not by 100 % clinical sensitivity. Conclusions: The results of our study confirm that measurement of cord blood bilirubin level can be used as a screening test for predicting the development of pathological jaundice that requires medical treatment.http://vestnik.szd.si/index.php/ZdravVest/article/view/267 |
| spellingShingle | Danijela Furlan Ana Ilijaš-Trofenik Vladimir Weber Zlata Felc Borut Bratanič Jana Lukač-Bajalo Cord blood Bilirubin as a predictor of Neonatal Hyperbilirubinemia Zdravniški Vestnik |
| title | Cord blood Bilirubin as a predictor of Neonatal Hyperbilirubinemia |
| title_full | Cord blood Bilirubin as a predictor of Neonatal Hyperbilirubinemia |
| title_fullStr | Cord blood Bilirubin as a predictor of Neonatal Hyperbilirubinemia |
| title_full_unstemmed | Cord blood Bilirubin as a predictor of Neonatal Hyperbilirubinemia |
| title_short | Cord blood Bilirubin as a predictor of Neonatal Hyperbilirubinemia |
| title_sort | cord blood bilirubin as a predictor of neonatal hyperbilirubinemia |
| url | http://vestnik.szd.si/index.php/ZdravVest/article/view/267 |
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