SARS-CoV2 variant-specific replicating RNA vaccines protect from disease following challenge with heterologous variants of concern

SARS-CoV2 variant-specific replicating RNA vaccines protect from disease following challenge with heterologous variants of concern

Despite mass public health efforts, the SARS-CoV2 pandemic continues as of late 2021 with resurgent case numbers in many parts of the world. The emergence of SARS-CoV2 variants of concern (VoCs) and evidence that existing vaccines that were designed to protect from the original strains of SARS-CoV-2...

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Bibliographic Details
Main Authors: David W Hawman, Kimberly Meade-White, Jacob Archer, Shanna S Leventhal, Drew Wilson, Carl Shaia, Samantha Randall, Amit P Khandhar, Kyle Krieger, Tien-Ying Hsiang, Michael Gale, Peter Berglund, Deborah Heydenburg Fuller, Heinz Feldmann, Jesse H Erasmus
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-02-01
Series:eLife
Subjects:
hamster
COVID-19
vaccine
RNA vaccine
replicon
Online Access:https://elifesciences.org/articles/75537

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