Cryochemically Obtained Nanoforms of Antimicrobial Drug Substance Dioxidine and Their Physico-chemical and Structural Properties
Nanoforms of the antimicrobial drug substance 2,3-bis-(hydroxymethyl) quinoxaline-N,N′-dioxide with particles sizes between 50 and 300 nm were obtained by cryochemical modification of the initial pharmaceutical substance using a freeze-drying technique and were characterized by different p...
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| Format: | Article |
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MDPI AG
2018-07-01
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| Series: | Crystals |
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| Online Access: | http://www.mdpi.com/2073-4352/8/7/298 |
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| author | Tatyana I. Shabatina Olga I. Vernaya Vladimir P. Shabatin Iuliia V. Evseeva Michail Ya Melnikov Andrew N. Fitch Vladimir V. Chernyshev |
| author_facet | Tatyana I. Shabatina Olga I. Vernaya Vladimir P. Shabatin Iuliia V. Evseeva Michail Ya Melnikov Andrew N. Fitch Vladimir V. Chernyshev |
| author_sort | Tatyana I. Shabatina |
| collection | DOAJ |
| description | Nanoforms of the antimicrobial drug substance 2,3-bis-(hydroxymethyl) quinoxaline-N,N′-dioxide with particles sizes between 50 and 300 nm were obtained by cryochemical modification of the initial pharmaceutical substance using a freeze-drying technique and were characterized by different physicochemical methods (FTIR, UV-Vis, 1H-NMR, DSC, TG and X-ray diffraction) and transmission electron microscopy (TEM). The data obtained from FTIR- and UV–Vis-spectroscopy confirmed the unaltered chemical structure of dioxidine molecules due to the cryochemical modification method. At the same time, X-ray diffraction and thermal analysis data show the change of the crystal structure compared to the parameters of the initial pharmaceutical dioxidine substance. A higher dissolution rate was revealed for cryomodified dioxidine nanoforms. The existence of three polymorphic crystal phases was established for cryomodified dioxidine samples possessed by some thermal activation processes: two anhydrous polymorphic phases, triclinic (T) and monoclinic (M), and one hydrated form (H). |
| first_indexed | 2024-04-11T12:36:46Z |
| format | Article |
| id | doaj.art-90ff2c22383f4846abf8aba6d496f40a |
| institution | Directory Open Access Journal |
| issn | 2073-4352 |
| language | English |
| last_indexed | 2024-04-11T12:36:46Z |
| publishDate | 2018-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Crystals |
| spelling | doaj.art-90ff2c22383f4846abf8aba6d496f40a2022-12-22T04:23:36ZengMDPI AGCrystals2073-43522018-07-018729810.3390/cryst8070298cryst8070298Cryochemically Obtained Nanoforms of Antimicrobial Drug Substance Dioxidine and Their Physico-chemical and Structural PropertiesTatyana I. Shabatina0Olga I. Vernaya1Vladimir P. Shabatin2Iuliia V. Evseeva3Michail Ya Melnikov4Andrew N. Fitch5Vladimir V. Chernyshev6Department of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gori build. 1/3, Moscow 119991, RussiaDepartment of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gori build. 1/3, Moscow 119991, RussiaDepartment of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gori build. 1/3, Moscow 119991, RussiaDepartment of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gori build. 1/3, Moscow 119991, RussiaDepartment of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gori build. 1/3, Moscow 119991, RussiaEuropean Synchrotron Radiation Faculty, B.P. 220, 38043 Grenoble CEDEX, FranceDepartment of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gori build. 1/3, Moscow 119991, RussiaNanoforms of the antimicrobial drug substance 2,3-bis-(hydroxymethyl) quinoxaline-N,N′-dioxide with particles sizes between 50 and 300 nm were obtained by cryochemical modification of the initial pharmaceutical substance using a freeze-drying technique and were characterized by different physicochemical methods (FTIR, UV-Vis, 1H-NMR, DSC, TG and X-ray diffraction) and transmission electron microscopy (TEM). The data obtained from FTIR- and UV–Vis-spectroscopy confirmed the unaltered chemical structure of dioxidine molecules due to the cryochemical modification method. At the same time, X-ray diffraction and thermal analysis data show the change of the crystal structure compared to the parameters of the initial pharmaceutical dioxidine substance. A higher dissolution rate was revealed for cryomodified dioxidine nanoforms. The existence of three polymorphic crystal phases was established for cryomodified dioxidine samples possessed by some thermal activation processes: two anhydrous polymorphic phases, triclinic (T) and monoclinic (M), and one hydrated form (H).http://www.mdpi.com/2073-4352/8/7/298drug nanoformscryochemical synthesispolymorphismantimicrobial substancesdioxidine |
| spellingShingle | Tatyana I. Shabatina Olga I. Vernaya Vladimir P. Shabatin Iuliia V. Evseeva Michail Ya Melnikov Andrew N. Fitch Vladimir V. Chernyshev Cryochemically Obtained Nanoforms of Antimicrobial Drug Substance Dioxidine and Their Physico-chemical and Structural Properties Crystals drug nanoforms cryochemical synthesis polymorphism antimicrobial substances dioxidine |
| title | Cryochemically Obtained Nanoforms of Antimicrobial Drug Substance Dioxidine and Their Physico-chemical and Structural Properties |
| title_full | Cryochemically Obtained Nanoforms of Antimicrobial Drug Substance Dioxidine and Their Physico-chemical and Structural Properties |
| title_fullStr | Cryochemically Obtained Nanoforms of Antimicrobial Drug Substance Dioxidine and Their Physico-chemical and Structural Properties |
| title_full_unstemmed | Cryochemically Obtained Nanoforms of Antimicrobial Drug Substance Dioxidine and Their Physico-chemical and Structural Properties |
| title_short | Cryochemically Obtained Nanoforms of Antimicrobial Drug Substance Dioxidine and Their Physico-chemical and Structural Properties |
| title_sort | cryochemically obtained nanoforms of antimicrobial drug substance dioxidine and their physico chemical and structural properties |
| topic | drug nanoforms cryochemical synthesis polymorphism antimicrobial substances dioxidine |
| url | http://www.mdpi.com/2073-4352/8/7/298 |
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