Proteoglycan 4 is Increased in Human Calcified Aortic Valves and Enhances Valvular Interstitial Cell Calcification

Proteoglycan 4 is Increased in Human Calcified Aortic Valves and Enhances Valvular Interstitial Cell Calcification

Aortic valve stenosis (AVS), a consequence of increased fibrosis and calcification of the aortic valve leaflets, causes progressive narrowing of the aortic valve. Proteoglycans, structural components of the aortic valve, accumulate in regions with fibrosis and moderate calcification. Particularly, p...

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Bibliographic Details
Main Authors: Gonzalo Artiach, Miguel Carracedo, Till Seime, Oscar Plunde, Andres Laguna-Fernandez, Ljubica Matic, Anders Franco-Cereceda, Magnus Bäck
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
proteoglycan 4
aortic valve stenosis
calcification
Online Access:https://www.mdpi.com/2073-4409/9/3/684

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