Validation and development of RP-HPLC method for quantification of glibenclamide in rat plasma and its application to pharmacokinetic studies in wistar rats

Validation and development of RP-HPLC method for quantification of glibenclamide in rat plasma and its application to pharmacokinetic studies in wistar rats

Herein, we report a novel, simple, specific, accurate and cost-friendly validated reverse phase-high performance liquid chromatographic (RP-HPLC) method for the quantification of second generation sulphonylurea based antidiabetic drug, glibenclamide (GLB) in rat plasma and its application to calcula...

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Bibliographic Details
Main Authors: Khalid Bashir Mir, Vidushi Abrol, Taha U. Wani, Ishrat Jan, Nasseb Singh, Nisar A. Khan, Alamgir A. Dar, Rania Mohammad Sabri Sultan, Showkat A. Lone, Mohamed A.M. Iesa, Sadeq K. Alhag, Laila A. Al-Shuraym, Nawal Helm, Ammar AL-Farga
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Heliyon
Subjects:
Pharmacokinetics
Glibenclamide
Wistar rats
RP-HPLC
Plasma
Method validation
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023080842

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