The RRM-mediated RNA binding activity in T. brucei RAP1 is essential for VSG monoallelic expression
Monoallelic VSG expression is essential for Trypanosoma brucei survival. Competition between TbRAP1’s RNA and dsDNA binding activities ensures that TbRAP1 sustains a high level expression of the active VSG while silencing other VSGs globally.
Bibliographic Details
| Main Authors: |
Amit Kumar Gaurav,
Marjia Afrin,
Xian Yang,
Arpita Saha,
S. K. Abdus Sayeed,
Xuehua Pan,
Zeyang Ji,
Kam-Bo Wong,
Mingjie Zhang,
Yanxiang Zhao,
Bibo Li |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-023-37307-0
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