Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis
Abstract Elevated uric acid (UA) levels have been reported in malaria patients and are particularly prominent in severe malaria cases. This study aims to synthesize the difference in UA levels between malaria patients and uninfected controls, and between patients with severe and non-severe malaria....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-42217-8 |
| _version_ | 1797452730821771264 |
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| author | Saruda Kuraeiad Kwuntida Uthaisar Kotepui Frederick Ramirez Masangkay Aongart Mahittikorn Manas Kotepui |
| author_facet | Saruda Kuraeiad Kwuntida Uthaisar Kotepui Frederick Ramirez Masangkay Aongart Mahittikorn Manas Kotepui |
| author_sort | Saruda Kuraeiad |
| collection | DOAJ |
| description | Abstract Elevated uric acid (UA) levels have been reported in malaria patients and are particularly prominent in severe malaria cases. This study aims to synthesize the difference in UA levels between malaria patients and uninfected controls, and between patients with severe and non-severe malaria. A comprehensive literature search was carried out across databases such as Embase, MEDLINE, Ovid, PubMed, Scopus, ProQuest, and Google Scholar to identify relevant studies for inclusion. The methodological quality of the included studies was evaluated independently by two reviewers using the JBI critical appraisal tool for observational studies. A meta-analysis was performed to calculate the pooled effect sizes, expressed as Hedges' g, with 95% confidence intervals (CIs). The Hedges' g was pooled using the random-effects model. An initial search yielding a total of 1122 articles, and a final total of 19 studies being included in the review. Elevated UA levels were observed more prominently in malaria patients, especially those with severe manifestations, when compared to uninfected controls. The conducted meta-analysis demonstrated a significant elevation in UA levels in patients suffering from malaria as compared to uninfected controls (P < 0.01, Hedges’s g = 1.40, 95% CI 0.84–1.95, I 2 = 95.81, 16 studies). The conducted meta-analysis demonstrated a significant elevation in UA levels in patients suffering from severe malaria as compared to non-severe malaria (P < 0.01, Hedges’s g = 3.45, 95% CI 1.06–5.83, I 2 = 98.73, 6 studies). In summary, these findings provide valuable insights into the potential use of UA as a biomarker for malaria infection and determination of its severity. Further research is needed to validate these findings and to explore the underlying mechanisms that contribute to the elevation of UA levels during malaria infection. |
| first_indexed | 2024-03-09T15:12:53Z |
| format | Article |
| id | doaj.art-9107a2dd917c4a4896ecd3525c0646c7 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:12:53Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-9107a2dd917c4a4896ecd3525c0646c72023-11-26T13:15:52ZengNature PortfolioScientific Reports2045-23222023-09-0113111210.1038/s41598-023-42217-8Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysisSaruda Kuraeiad0Kwuntida Uthaisar Kotepui1Frederick Ramirez Masangkay2Aongart Mahittikorn3Manas Kotepui4Medical Technology, School of Allied Health Sciences, Walailak UniversityMedical Technology, School of Allied Health Sciences, Walailak UniversityDepartment of Medical Technology, Faculty of Pharmacy, University of Santo TomasDepartment of Protozoology, Faculty of Tropical Medicine, Mahidol UniversityMedical Technology, School of Allied Health Sciences, Walailak UniversityAbstract Elevated uric acid (UA) levels have been reported in malaria patients and are particularly prominent in severe malaria cases. This study aims to synthesize the difference in UA levels between malaria patients and uninfected controls, and between patients with severe and non-severe malaria. A comprehensive literature search was carried out across databases such as Embase, MEDLINE, Ovid, PubMed, Scopus, ProQuest, and Google Scholar to identify relevant studies for inclusion. The methodological quality of the included studies was evaluated independently by two reviewers using the JBI critical appraisal tool for observational studies. A meta-analysis was performed to calculate the pooled effect sizes, expressed as Hedges' g, with 95% confidence intervals (CIs). The Hedges' g was pooled using the random-effects model. An initial search yielding a total of 1122 articles, and a final total of 19 studies being included in the review. Elevated UA levels were observed more prominently in malaria patients, especially those with severe manifestations, when compared to uninfected controls. The conducted meta-analysis demonstrated a significant elevation in UA levels in patients suffering from malaria as compared to uninfected controls (P < 0.01, Hedges’s g = 1.40, 95% CI 0.84–1.95, I 2 = 95.81, 16 studies). The conducted meta-analysis demonstrated a significant elevation in UA levels in patients suffering from severe malaria as compared to non-severe malaria (P < 0.01, Hedges’s g = 3.45, 95% CI 1.06–5.83, I 2 = 98.73, 6 studies). In summary, these findings provide valuable insights into the potential use of UA as a biomarker for malaria infection and determination of its severity. Further research is needed to validate these findings and to explore the underlying mechanisms that contribute to the elevation of UA levels during malaria infection.https://doi.org/10.1038/s41598-023-42217-8 |
| spellingShingle | Saruda Kuraeiad Kwuntida Uthaisar Kotepui Frederick Ramirez Masangkay Aongart Mahittikorn Manas Kotepui Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis Scientific Reports |
| title | Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis |
| title_full | Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis |
| title_fullStr | Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis |
| title_full_unstemmed | Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis |
| title_short | Association of uric acid levels with severity of Plasmodium infections: a systematic review and meta-analysis |
| title_sort | association of uric acid levels with severity of plasmodium infections a systematic review and meta analysis |
| url | https://doi.org/10.1038/s41598-023-42217-8 |
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