Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology
The APOE4 allele is the leading risk factor for late-onset Alzheimer’s disease, but how it might contribute to the disease is not clear. Here the authors show that a mouse expressing the human APOE4 allele displays hyperactivity in the entorhinal cortex due to a decreased inhibitory tone, which may...
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Bibliographic Details
| Main Authors: |
Tal Nuriel,
Sergio L. Angulo,
Usman Khan,
Archana Ashok,
Qiuying Chen,
Helen Y. Figueroa,
Sheina Emrani,
Li Liu,
Mathieu Herman,
Geoffrey Barrett,
Valerie Savage,
Luna Buitrago,
Efrain Cepeda-Prado,
Christine Fung,
Eliana Goldberg,
Steven S. Gross,
S. Abid Hussaini,
Herman Moreno,
Scott A. Small,
Karen E. Duff |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2017-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-017-01444-0
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