A Systematic Analysis of the Role of Unc-5 Netrin Receptor A (UNC5A) in Human Cancers
Unc-5 netrin receptor A (UNC5A), a netrin family receptor, plays a key role in neuronal development and subsequent differentiation. Recently, studies have found that UNC5A plays an important role in multiple cancers, such as bladder cancer, non-small cell lung carcinoma, and colon cancer but its pan...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/12/12/1826 |
| _version_ | 1827641544486682624 |
|---|---|
| author | Zonglang Zhou Bingfu Fan Hongrong Cheng Ming Wang Jun Xie Mingyuan Zou Yi Yang |
| author_facet | Zonglang Zhou Bingfu Fan Hongrong Cheng Ming Wang Jun Xie Mingyuan Zou Yi Yang |
| author_sort | Zonglang Zhou |
| collection | DOAJ |
| description | Unc-5 netrin receptor A (UNC5A), a netrin family receptor, plays a key role in neuronal development and subsequent differentiation. Recently, studies have found that UNC5A plays an important role in multiple cancers, such as bladder cancer, non-small cell lung carcinoma, and colon cancer but its pan-cancer function is largely unknown. Herein, the R software and multiple databases or online websites (The Cancer Genome Atlas (TCGA), The Genotype-Tissue Expression (GTEx), The Tumor Immune Estimation Resource (TIMER), The Gene Set Cancer Analysis (GSCA), Gene Expression Profiling Interactive Analysis (GEPIA), and cBioPortal etc.) were utilized to examine the role of UNC5A in pan-cancer. UNC5A was found to be highly expressed across multiple human cancer tissues and cells, was linked to clinical outcomes of patients, and was a potential pan-cancer biomarker. The mutational landscape of UNC5A exhibited that patients with UNC5A mutations had poorer progress free survival (PFS) in head and neck squamous cell carcinoma (HNSC) and prostate adenocarcinoma (PRAD). Furthermore, UNC5A expression was associated with tumor mutation burden (TMB), neoantigen, tumor microenvironment (TME), tumor microsatellite instability (MSI), immunomodulators, immune infiltration, DNA methylation, immune checkpoint (ICP) genes, and drug responses. Our results suggest the potential of UNC5A as a pan-cancer biomarker and an efficient immunotherapy target, which may also guide drug selection for some specific cancer types in clinical practice. |
| first_indexed | 2024-03-09T17:16:22Z |
| format | Article |
| id | doaj.art-910c7cdbe0a9413ea1a180d8e1136ef8 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T17:16:22Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-910c7cdbe0a9413ea1a180d8e1136ef82023-11-24T13:34:01ZengMDPI AGBiomolecules2218-273X2022-12-011212182610.3390/biom12121826A Systematic Analysis of the Role of Unc-5 Netrin Receptor A (UNC5A) in Human CancersZonglang Zhou0Bingfu Fan1Hongrong Cheng2Ming Wang3Jun Xie4Mingyuan Zou5Yi Yang6Department of Internal Medicine, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Zhejiang Provincial People’s Hospital, Hangzhou 310000, ChinaInternational Institutes of Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, ChinaDepartment of Endocrinology, Yongding Hospital, Suzhou 215000, ChinaInternational Institutes of Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, ChinaMedical School, Southeast University, Nanjing 210009, ChinaInternational Institutes of Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, ChinaUnc-5 netrin receptor A (UNC5A), a netrin family receptor, plays a key role in neuronal development and subsequent differentiation. Recently, studies have found that UNC5A plays an important role in multiple cancers, such as bladder cancer, non-small cell lung carcinoma, and colon cancer but its pan-cancer function is largely unknown. Herein, the R software and multiple databases or online websites (The Cancer Genome Atlas (TCGA), The Genotype-Tissue Expression (GTEx), The Tumor Immune Estimation Resource (TIMER), The Gene Set Cancer Analysis (GSCA), Gene Expression Profiling Interactive Analysis (GEPIA), and cBioPortal etc.) were utilized to examine the role of UNC5A in pan-cancer. UNC5A was found to be highly expressed across multiple human cancer tissues and cells, was linked to clinical outcomes of patients, and was a potential pan-cancer biomarker. The mutational landscape of UNC5A exhibited that patients with UNC5A mutations had poorer progress free survival (PFS) in head and neck squamous cell carcinoma (HNSC) and prostate adenocarcinoma (PRAD). Furthermore, UNC5A expression was associated with tumor mutation burden (TMB), neoantigen, tumor microenvironment (TME), tumor microsatellite instability (MSI), immunomodulators, immune infiltration, DNA methylation, immune checkpoint (ICP) genes, and drug responses. Our results suggest the potential of UNC5A as a pan-cancer biomarker and an efficient immunotherapy target, which may also guide drug selection for some specific cancer types in clinical practice.https://www.mdpi.com/2218-273X/12/12/1826UNC5Abiomarkertumor immunityimmunotherapy target |
| spellingShingle | Zonglang Zhou Bingfu Fan Hongrong Cheng Ming Wang Jun Xie Mingyuan Zou Yi Yang A Systematic Analysis of the Role of Unc-5 Netrin Receptor A (UNC5A) in Human Cancers Biomolecules UNC5A biomarker tumor immunity immunotherapy target |
| title | A Systematic Analysis of the Role of Unc-5 Netrin Receptor A (UNC5A) in Human Cancers |
| title_full | A Systematic Analysis of the Role of Unc-5 Netrin Receptor A (UNC5A) in Human Cancers |
| title_fullStr | A Systematic Analysis of the Role of Unc-5 Netrin Receptor A (UNC5A) in Human Cancers |
| title_full_unstemmed | A Systematic Analysis of the Role of Unc-5 Netrin Receptor A (UNC5A) in Human Cancers |
| title_short | A Systematic Analysis of the Role of Unc-5 Netrin Receptor A (UNC5A) in Human Cancers |
| title_sort | systematic analysis of the role of unc 5 netrin receptor a unc5a in human cancers |
| topic | UNC5A biomarker tumor immunity immunotherapy target |
| url | https://www.mdpi.com/2218-273X/12/12/1826 |
| work_keys_str_mv | AT zonglangzhou asystematicanalysisoftheroleofunc5netrinreceptoraunc5ainhumancancers AT bingfufan asystematicanalysisoftheroleofunc5netrinreceptoraunc5ainhumancancers AT hongrongcheng asystematicanalysisoftheroleofunc5netrinreceptoraunc5ainhumancancers AT mingwang asystematicanalysisoftheroleofunc5netrinreceptoraunc5ainhumancancers AT junxie asystematicanalysisoftheroleofunc5netrinreceptoraunc5ainhumancancers AT mingyuanzou asystematicanalysisoftheroleofunc5netrinreceptoraunc5ainhumancancers AT yiyang asystematicanalysisoftheroleofunc5netrinreceptoraunc5ainhumancancers AT zonglangzhou systematicanalysisoftheroleofunc5netrinreceptoraunc5ainhumancancers AT bingfufan systematicanalysisoftheroleofunc5netrinreceptoraunc5ainhumancancers AT hongrongcheng systematicanalysisoftheroleofunc5netrinreceptoraunc5ainhumancancers AT mingwang systematicanalysisoftheroleofunc5netrinreceptoraunc5ainhumancancers AT junxie systematicanalysisoftheroleofunc5netrinreceptoraunc5ainhumancancers AT mingyuanzou systematicanalysisoftheroleofunc5netrinreceptoraunc5ainhumancancers AT yiyang systematicanalysisoftheroleofunc5netrinreceptoraunc5ainhumancancers |