Cellular mechanisms of heterogeneity in NF2-mutant schwannoma
Schwannomas are mainly caused by NF2 tumour suppressor inactivation, but they display intratumoural heterogeneity. Here the authors show that this heterogeneity is caused by the loss of polarity and acquisition of different programmes of ErbB ligand production in NF2-mutant Schwann cells.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37226-0 |
| _version_ | 1797864227724066816 |
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| author | Christine Chiasson-MacKenzie Jeremie Vitte Ching-Hui Liu Emily A. Wright Elizabeth A. Flynn Shannon L. Stott Marco Giovannini Andrea I. McClatchey |
| author_facet | Christine Chiasson-MacKenzie Jeremie Vitte Ching-Hui Liu Emily A. Wright Elizabeth A. Flynn Shannon L. Stott Marco Giovannini Andrea I. McClatchey |
| author_sort | Christine Chiasson-MacKenzie |
| collection | DOAJ |
| description | Schwannomas are mainly caused by NF2 tumour suppressor inactivation, but they display intratumoural heterogeneity. Here the authors show that this heterogeneity is caused by the loss of polarity and acquisition of different programmes of ErbB ligand production in NF2-mutant Schwann cells. |
| first_indexed | 2024-04-09T22:48:22Z |
| format | Article |
| id | doaj.art-910ca0cc6a5e4813874a61e9dbcdad7c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:48:22Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-910ca0cc6a5e4813874a61e9dbcdad7c2023-03-22T11:43:08ZengNature PortfolioNature Communications2041-17232023-03-0114111710.1038/s41467-023-37226-0Cellular mechanisms of heterogeneity in NF2-mutant schwannomaChristine Chiasson-MacKenzie0Jeremie Vitte1Ching-Hui Liu2Emily A. Wright3Elizabeth A. Flynn4Shannon L. Stott5Marco Giovannini6Andrea I. McClatchey7Massachusetts General Hospital Cancer Center, Harvard Medical SchoolDepartment of Head and Neck Surgery, David Geffen School of Medicine at UCLA and Jonsson Comprehensive Cancer Center (JCCC), University of California Los AngelesMassachusetts General Hospital Cancer Center, Harvard Medical SchoolMassachusetts General Hospital Cancer Center, Harvard Medical SchoolMassachusetts General Hospital Cancer Center, Harvard Medical SchoolMassachusetts General Hospital Cancer Center, Harvard Medical SchoolDepartment of Head and Neck Surgery, David Geffen School of Medicine at UCLA and Jonsson Comprehensive Cancer Center (JCCC), University of California Los AngelesMassachusetts General Hospital Cancer Center, Harvard Medical SchoolSchwannomas are mainly caused by NF2 tumour suppressor inactivation, but they display intratumoural heterogeneity. Here the authors show that this heterogeneity is caused by the loss of polarity and acquisition of different programmes of ErbB ligand production in NF2-mutant Schwann cells.https://doi.org/10.1038/s41467-023-37226-0 |
| spellingShingle | Christine Chiasson-MacKenzie Jeremie Vitte Ching-Hui Liu Emily A. Wright Elizabeth A. Flynn Shannon L. Stott Marco Giovannini Andrea I. McClatchey Cellular mechanisms of heterogeneity in NF2-mutant schwannoma Nature Communications |
| title | Cellular mechanisms of heterogeneity in NF2-mutant schwannoma |
| title_full | Cellular mechanisms of heterogeneity in NF2-mutant schwannoma |
| title_fullStr | Cellular mechanisms of heterogeneity in NF2-mutant schwannoma |
| title_full_unstemmed | Cellular mechanisms of heterogeneity in NF2-mutant schwannoma |
| title_short | Cellular mechanisms of heterogeneity in NF2-mutant schwannoma |
| title_sort | cellular mechanisms of heterogeneity in nf2 mutant schwannoma |
| url | https://doi.org/10.1038/s41467-023-37226-0 |
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