Radioprotective Effect of Aminothiol PrC-210 on Irradiated Inner Ear of Guinea Pig.
Radiotherapy of individuals suffering with head & neck or brain tumors subserve the risk of sensorineural hearing loss. Here, we evaluated the protective effect of Aminothiol PrC-210 (3-(methyl-amino)-2-((methylamino)methyl)propane-1-thiol) on the irradiated inner ear of guinea pigs. An intra-pe...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4657906?pdf=render |
| _version_ | 1811301828228284416 |
|---|---|
| author | Arnaud P J Giese Jess G Guarnaschelli Jonette A Ward Daniel I Choo Saima Riazuddin Zubair M Ahmed |
| author_facet | Arnaud P J Giese Jess G Guarnaschelli Jonette A Ward Daniel I Choo Saima Riazuddin Zubair M Ahmed |
| author_sort | Arnaud P J Giese |
| collection | DOAJ |
| description | Radiotherapy of individuals suffering with head & neck or brain tumors subserve the risk of sensorineural hearing loss. Here, we evaluated the protective effect of Aminothiol PrC-210 (3-(methyl-amino)-2-((methylamino)methyl)propane-1-thiol) on the irradiated inner ear of guinea pigs. An intra-peritoneal or intra-tympanic dose of PrC-210 was administered prior to receiving a dose of gamma radiation (3000 cGy) to each ear. Auditory Brainstem Responses (ABRs) were recorded one week and two weeks after the radiation and compared with the sham animal group. ABR thresholds of guinea pigs that received an intra-peritoneal dose of PrC-210 were significantly better compared to the non-treated, control animals at one week post-radiation. Morphologic analysis of the inner ear revealed significant inflammation and degeneration of the spiral ganglion in the irradiated animals not treated with PrC-210. In contrast, when treated with PrC-210 the radiation effect and injury to the spiral ganglion was significantly alleviated. PrC-210 had no apparent cytotoxic effect in vivo and did not affect the morphology or count of cochlear hair cells. These findings suggest that aminothiol PrC-210 attenuated radiation-induced cochlea damage for at least one week and protected hearing. |
| first_indexed | 2024-04-13T07:15:48Z |
| format | Article |
| id | doaj.art-910d9d714c8840d188072125713d9af6 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T07:15:48Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-910d9d714c8840d188072125713d9af62022-12-22T02:56:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011011e014360610.1371/journal.pone.0143606Radioprotective Effect of Aminothiol PrC-210 on Irradiated Inner Ear of Guinea Pig.Arnaud P J GieseJess G GuarnaschelliJonette A WardDaniel I ChooSaima RiazuddinZubair M AhmedRadiotherapy of individuals suffering with head & neck or brain tumors subserve the risk of sensorineural hearing loss. Here, we evaluated the protective effect of Aminothiol PrC-210 (3-(methyl-amino)-2-((methylamino)methyl)propane-1-thiol) on the irradiated inner ear of guinea pigs. An intra-peritoneal or intra-tympanic dose of PrC-210 was administered prior to receiving a dose of gamma radiation (3000 cGy) to each ear. Auditory Brainstem Responses (ABRs) were recorded one week and two weeks after the radiation and compared with the sham animal group. ABR thresholds of guinea pigs that received an intra-peritoneal dose of PrC-210 were significantly better compared to the non-treated, control animals at one week post-radiation. Morphologic analysis of the inner ear revealed significant inflammation and degeneration of the spiral ganglion in the irradiated animals not treated with PrC-210. In contrast, when treated with PrC-210 the radiation effect and injury to the spiral ganglion was significantly alleviated. PrC-210 had no apparent cytotoxic effect in vivo and did not affect the morphology or count of cochlear hair cells. These findings suggest that aminothiol PrC-210 attenuated radiation-induced cochlea damage for at least one week and protected hearing.http://europepmc.org/articles/PMC4657906?pdf=render |
| spellingShingle | Arnaud P J Giese Jess G Guarnaschelli Jonette A Ward Daniel I Choo Saima Riazuddin Zubair M Ahmed Radioprotective Effect of Aminothiol PrC-210 on Irradiated Inner Ear of Guinea Pig. PLoS ONE |
| title | Radioprotective Effect of Aminothiol PrC-210 on Irradiated Inner Ear of Guinea Pig. |
| title_full | Radioprotective Effect of Aminothiol PrC-210 on Irradiated Inner Ear of Guinea Pig. |
| title_fullStr | Radioprotective Effect of Aminothiol PrC-210 on Irradiated Inner Ear of Guinea Pig. |
| title_full_unstemmed | Radioprotective Effect of Aminothiol PrC-210 on Irradiated Inner Ear of Guinea Pig. |
| title_short | Radioprotective Effect of Aminothiol PrC-210 on Irradiated Inner Ear of Guinea Pig. |
| title_sort | radioprotective effect of aminothiol prc 210 on irradiated inner ear of guinea pig |
| url | http://europepmc.org/articles/PMC4657906?pdf=render |
| work_keys_str_mv | AT arnaudpjgiese radioprotectiveeffectofaminothiolprc210onirradiatedinnerearofguineapig AT jessgguarnaschelli radioprotectiveeffectofaminothiolprc210onirradiatedinnerearofguineapig AT jonetteaward radioprotectiveeffectofaminothiolprc210onirradiatedinnerearofguineapig AT danielichoo radioprotectiveeffectofaminothiolprc210onirradiatedinnerearofguineapig AT saimariazuddin radioprotectiveeffectofaminothiolprc210onirradiatedinnerearofguineapig AT zubairmahmed radioprotectiveeffectofaminothiolprc210onirradiatedinnerearofguineapig |