Dietary Supplementation with Sea Buckthorn Berry Puree Alters Plasma Metabolomic Profile and Gut Microbiota Composition in Hypercholesterolemia Population
Sea buckthorn berries have been reported to have beneficial effects on plasma lipid profile and cardiovascular health. This study aimed to investigate the impact of intervention with sea buckthorn berry puree on plasma metabolomics profile and gut microbiota in hypercholesterolemic subjects. A total...
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MDPI AG
2022-08-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/11/16/2481 |
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| author | Kang Chen Fangfei Zhou Jian Zhang Pin Li Yumei Zhang Baoru Yang |
| author_facet | Kang Chen Fangfei Zhou Jian Zhang Pin Li Yumei Zhang Baoru Yang |
| author_sort | Kang Chen |
| collection | DOAJ |
| description | Sea buckthorn berries have been reported to have beneficial effects on plasma lipid profile and cardiovascular health. This study aimed to investigate the impact of intervention with sea buckthorn berry puree on plasma metabolomics profile and gut microbiota in hypercholesterolemic subjects. A total of 56 subjects with hypercholesterolemia consumed 90 g of sea buckthorn berry puree daily for 90 days, and plasma metabolomic profile was studied at 0 (baseline), 45, and 90 days of intervention by using proton nuclear magnetic resonance spectroscopy (<sup>1</sup>H NMR). Gut microbiota composition was analyzed at the baseline and after 90 days of supplementation by using high-throughput sequencing. The plasma metabolic profile was significantly altered after 45 days of intervention as compared to the baseline (day 0). A clear trend of returning to the baseline metabolomic profile was observed in plasma when the intervention extended from 45 days to 90 days. Despite this, the levels of several key plasma metabolites such as glucose, lactate, and creatine were lowered at day 90 compared to the baseline levels, suggesting an improved energy metabolism in those patients. In addition, intervention with sea buckthorn puree enriched butyrate-producing bacteria and other gut microbes linked to lipid metabolisms such as <i>Prevotella</i> and <i>Faecalibacterium</i> while depleting <i>Parasutterella</i> associated with increased risks of cardiovascular disease. These findings indicate that sea buckthorn berries have potential in modulating energy metabolism and the gut microbiota composition in hypercholesterolemic patients. |
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| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-09T04:26:00Z |
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| spelling | doaj.art-910e17737b634c4898afa4225df2c2e42023-12-03T13:40:36ZengMDPI AGFoods2304-81582022-08-011116248110.3390/foods11162481Dietary Supplementation with Sea Buckthorn Berry Puree Alters Plasma Metabolomic Profile and Gut Microbiota Composition in Hypercholesterolemia PopulationKang Chen0Fangfei Zhou1Jian Zhang2Pin Li3Yumei Zhang4Baoru Yang5Food Sciences, Department of Life Technologies, University of Turku, 20014 Turku, FinlandDepartment of Nutrition and Food Hygiene, School of Public Health, Beijing University, Beijing 100191, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Beijing University, Beijing 100191, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Beijing University, Beijing 100191, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Beijing University, Beijing 100191, ChinaFood Sciences, Department of Life Technologies, University of Turku, 20014 Turku, FinlandSea buckthorn berries have been reported to have beneficial effects on plasma lipid profile and cardiovascular health. This study aimed to investigate the impact of intervention with sea buckthorn berry puree on plasma metabolomics profile and gut microbiota in hypercholesterolemic subjects. A total of 56 subjects with hypercholesterolemia consumed 90 g of sea buckthorn berry puree daily for 90 days, and plasma metabolomic profile was studied at 0 (baseline), 45, and 90 days of intervention by using proton nuclear magnetic resonance spectroscopy (<sup>1</sup>H NMR). Gut microbiota composition was analyzed at the baseline and after 90 days of supplementation by using high-throughput sequencing. The plasma metabolic profile was significantly altered after 45 days of intervention as compared to the baseline (day 0). A clear trend of returning to the baseline metabolomic profile was observed in plasma when the intervention extended from 45 days to 90 days. Despite this, the levels of several key plasma metabolites such as glucose, lactate, and creatine were lowered at day 90 compared to the baseline levels, suggesting an improved energy metabolism in those patients. In addition, intervention with sea buckthorn puree enriched butyrate-producing bacteria and other gut microbes linked to lipid metabolisms such as <i>Prevotella</i> and <i>Faecalibacterium</i> while depleting <i>Parasutterella</i> associated with increased risks of cardiovascular disease. These findings indicate that sea buckthorn berries have potential in modulating energy metabolism and the gut microbiota composition in hypercholesterolemic patients.https://www.mdpi.com/2304-8158/11/16/2481hypercholesterolemia population<i>Hippophaë rhamnoides</i>sea buckthorn berriesplasma metabolomic profilegut microbiota |
| spellingShingle | Kang Chen Fangfei Zhou Jian Zhang Pin Li Yumei Zhang Baoru Yang Dietary Supplementation with Sea Buckthorn Berry Puree Alters Plasma Metabolomic Profile and Gut Microbiota Composition in Hypercholesterolemia Population Foods hypercholesterolemia population <i>Hippophaë rhamnoides</i> sea buckthorn berries plasma metabolomic profile gut microbiota |
| title | Dietary Supplementation with Sea Buckthorn Berry Puree Alters Plasma Metabolomic Profile and Gut Microbiota Composition in Hypercholesterolemia Population |
| title_full | Dietary Supplementation with Sea Buckthorn Berry Puree Alters Plasma Metabolomic Profile and Gut Microbiota Composition in Hypercholesterolemia Population |
| title_fullStr | Dietary Supplementation with Sea Buckthorn Berry Puree Alters Plasma Metabolomic Profile and Gut Microbiota Composition in Hypercholesterolemia Population |
| title_full_unstemmed | Dietary Supplementation with Sea Buckthorn Berry Puree Alters Plasma Metabolomic Profile and Gut Microbiota Composition in Hypercholesterolemia Population |
| title_short | Dietary Supplementation with Sea Buckthorn Berry Puree Alters Plasma Metabolomic Profile and Gut Microbiota Composition in Hypercholesterolemia Population |
| title_sort | dietary supplementation with sea buckthorn berry puree alters plasma metabolomic profile and gut microbiota composition in hypercholesterolemia population |
| topic | hypercholesterolemia population <i>Hippophaë rhamnoides</i> sea buckthorn berries plasma metabolomic profile gut microbiota |
| url | https://www.mdpi.com/2304-8158/11/16/2481 |
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